Scientists have uncovered a potential approach to treat one of the commonest causes of dementia and stroke in older people.
Studies with rats found the treatment can reverse changes in blood vessels in the brain associated with the condition, called cerebral small vessel disease.
Treatment also prevents damage to brain cells caused by these blood vessel changes, raising hope that it could offer a therapy for dementia.
Small vessel disease, or SVD, is a major cause of dementia and can also worsen the symptoms of Alzheimer’s disease. It is responsible for almost half of all dementia cases in the UK and is a major cause of stroke, accounting for around one in five cases.
Patients with SVD are diagnosed from brain scans, which detect damage to white matter – a key component of the brain’s wiring.
Until now, it was not known how changes in small blood vessels in the brain associated with SVD can cause damage to brain cells.
A team led by the University of Edinburgh found that SVD occurs when cells that line the small blood vessels in the brain become dysfunctional. This causes them to secrete a molecule into the brain.
The molecule stops production of the protective layer that surrounds brain cells – called myelin – which leads to brain damage.
Treating rats with drugs that stop blood vessel cells from becoming dysfunctional reversed the symptoms of SVD and prevented brain damage, tests found.
Researchers say that further studies will need to test whether the treatment also works when the disease is firmly established. They will also need to check if the treatment can reverse the symptoms of dementia.
Dementia is one of the biggest problems facing society, as people live longer and the population ages. Estimates indicate there are almost 47 million people living with dementia worldwide and the numbers affected are expected to double every 20 years, rising to more than 115 million by 2050.
The research, published in Science Translational Medicine, was carried out at the Medical Research Council Centre for Regenerative Medicine and the UK Dementia Research Institute at the University of Edinburgh. It was funded by the MRC, Alzheimer’s Research UK and Fondation Leducq.
Professor Anna Williams, Group Leader at the University of Edinburgh’s MRC Centre for Regenerative Medicine, said: “This important research helps us understand why small vessel disease happens, providing a direct link between small blood vessels and changes in the brain that are linked to dementia. It also shows that these changes may be reversible, which paves the way for potential treatments.”
Dr Sara Imarisio, Head of Research at Alzheimer’s Research UK said: “Changes to the blood supply in the brain play an important role in Alzheimer’s disease as well as being a direct cause of vascular dementia. This pioneering research highlights a molecular link between changes to small blood vessels in the brain and damage to the insulating ‘white matter’ that helps nerve cells to send signals around the brain.
“The findings highlight a promising direction for research into treatments that could limit the damaging effects of blood vessel changes and help keep nerve cells functioning for longer. There are currently no drugs that slow down or stop Alzheimer’s disease and no treatments to help people living with vascular dementia. Alzheimer’s Research UK is very pleased to have helped fund this innovative research, which is only possible thanks to the work of our dedicated supporters.”
Receive an email update when we add a new SMALL VESSEL DISEASE article.
The Latest on: Small vessel disease
via Google News
The Latest on: Small vessel disease
- Transgenic rat model may provide new insights into cerebral amyloid angiopathy on November 13, 2018 at 12:26 am
rTg-DI rats will provide an improved platform for the development of biomarkers and preclinical testing of therapeutic interventions for this common small vessel disease." […]
- New drug shows promise for preventing and even reversing damage from age-related dementia and stroke on August 29, 2018 at 7:54 pm
A new discovery into the mechanism behind cerebral small vessel disease may offer new treatments to prevent or even repair damage associated with age-related dementia(Credit: Giovanni_Cancemi/Depositp... […]
- Brain study paves way for therapy for common cause of dementia on July 4, 2018 at 11:02 am
Studies with rats found the treatment can reverse changes in blood vessels in the brain associated with the condition, called cerebral small vessel disease. Treatment also prevents damage to brain cel... […]
- Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats on July 4, 2018 at 11:00 am
1 Medical Research Council (MRC) Centre for Regenerative Medicine and UK Dementia Research Institute, University of Edinburgh, Edinburgh EH16 4UU, UK. 2 Institute of Cardiovascular and Medical Science... […]
- Small Vessel Brain Disease on September 29, 2017 at 5:00 pm
Your heart transports oxygenated blood and nutrients throughout your body via the circulatory system, which consists of arteries and veins. Your blood vessels become smaller in size the farther they a... […]
- Small Vessel Disease on August 14, 2017 at 9:51 pm
Small vessel heart disease is a condition that affects the walls and inner lining of tiny coronary artery blood vessels that branch off from the larger coronary arteries (which supply blood to the hea... […]
- Memory loss and other cognitive decline linked to blood vessel disease in the brain on June 6, 2017 at 5:53 am
The subjects were given cognitive tests and brain MRIs. The MRIs were examined for four main components of small vessel disease (SVD). These four components, which include evidence of microbleeds and ... […]
- MRI progression of cerebral small vessel disease and cognitive decline in patients with hypertension on October 19, 2016 at 5:00 pm
Objective: Hypertension is associated with cognitive deficits, probably because it is a major risk factor for the development of white matter hyperintensities (WMH), lacunes, and cerebral microbleeds, ... […]
- Prevalence of Cerebral Small-Vessel Disease in Long-Term Breast Cancer Survivors Exposed to Both Adjuvant Radiotherapy and Chemotherapy on September 21, 2016 at 5:00 pm
Show More Vincent Koppelmans, University of Michigan, School of Kinesiology, Ann Arbor, MI; Vincent Koppelmans, Meike W. Vernooij, Caroline Seynaeve, and M. Arfan Ikram, Erasmus University Medical Cen... […]
via Bing News