Activating GPR139 in rats reduced excessive alcohol use and pain of withdrawal
Activation of a receptor with no known function in the brain reduces excessive alcohol use and the pain of withdrawal, according to preclinical research in male rats. The study, published in eNeuro, suggests a new approach towards the treatment of alcohol use disorder.
More than a third of approved pharmaceutical drugs target G protein-coupled receptors (GPCRs). One receptor belonging to this family, GPR139, is highly expressed in the habenula — a brain region with a critical role in addiction.
Olivier George and colleagues used a rat model of alcohol dependence and a substance that activates GPR139 to establish a previously unknown role for the receptor in addiction-like behavior. The researchers found that activation of GPR139 reduced alcohol intake and restored pain sensitivity thresholds only in alcohol-dependent mice that showed compulsive-like alcohol consumption akin to problematic drinking in humans. This study is the first to establish an effect of GPR139 manipulation on behavior and encourages investigation of the receptor as a potential drug target in the development of medications for alcohol dependence.
Learn more: New target for treating alcoholism
Receive an email update when we add a new ALCOHOL USE DISORDER article.
The Latest on: Alcohol use disorder
via Google News
The Latest on: Alcohol use disorder
- Adial Pharmaceuticals looks to apply its alcohol-use disorder drug to opioid-use disorder on December 14, 2018 at 4:44 am
Adial Pharmaceuticals Inc (NASDAQ:ADIL) plans to expand the potential of its lead drug AD04, designed to treat alcohol-use disorder, to benefit patients with opioid-use disorder. A Phase 2b clinical t... […]
- The Medical Journal of Australia has diagnosed James Bond with “severe alcohol use disorder” on December 13, 2018 at 6:19 pm
In news that may leave you shaken and possibly stirred, The Medical Journal of Australia recently published a study concluding that James Bond has a serious alcohol problem. No, that problem isn’t the ... […]
- MU researchers: The way to determine alcohol use disorders must change on December 13, 2018 at 4:13 am
“The published scientific literature on daily drinking consequences are often not based upon the actual number of drinks on a given drinking day,” said Kenneth J. Sher, MU Curators ... […]
- James Bond Has a 'Severe' Drinking Problem, Exhibits Most Criteria for Alcohol Use Disorder, Experts Say on December 11, 2018 at 7:40 am
James Bond, the fictional British spy known for his love of "shaken, not stirred" martinis, has been working for the U.K.'s secret service all while harboring a potentially fatal drinking problem, acc... […]
- Alcohol-Use Disorder on December 5, 2018 at 11:58 pm
ClinicalAdvisor.com is for nurse practitioners and physician assistants, offering the latest information on diagnosing, treating, managing, and preventing medical conditions typically seen in the offi... […]
- The way to determine alcohol use disorders must change on December 5, 2018 at 2:17 am
“The published scientific literature on daily drinking consequences are often not based upon the actual number of drinks on a given drinking day,” said Kenneth J. Sher, MU Curators Distinguished Profe... […]
- Adial Pharmaceuticals Establishes Scientific Advisory Board and Appoints Global Thought Leader in the Field of Alcohol Use Disorder on December 3, 2018 at 5:31 pm
CHARLOTTESVILLE, Va., Nov. 29, 2018 (GLOBE NEWSWIRE) -- Adial Pharmaceuticals, Inc. (NASDAQ:ADIL; ADILW), www.adialpharma.com, a clinical-stage biopharmaceutical company focused on the development of ... […]
- A New Study Says There Are 5 Different Types of Problem Drinkers. Here's What They Are on November 30, 2018 at 10:25 am
People who exceed these benchmarks are considered at risk for alcohol use disorder, as well as health conditions such as cancer and cognitive decline. As clear as these definitions are on paper, howev... […]
- Study finds 5 types of alcohol use disorder that vary with age on November 27, 2018 at 8:03 am
Healthline Media, Inc. would like to process and share personal data (e.g., mobile ad id) and data about your use of our site (e.g., content interests) with our third party partners (see a current lis... […]
via Bing News