Bartenders and cooks have long recognized the value of an orange twist, but thanks to researchers at the University of Central Florida, squeezing oranges may give us a new way to deliver medicine or to detect bridge failures before they happen.
Engineering Assistant Professor Andrew K. Dickerson and graduate student Nicholas M. Smith have figured out the mechanics of how oranges release that thin stream of fragrant oil when squeezed. They characterized the orange peels’ structure and figured out the role the layers have to create the microjet dynamic. By mimicking nature’s mechanism of an orange layer, pharmaceutical companies may be able to develop a less expensive and less complex way to deliver airborne medication.
“We study natural systems to mathematically characterize how creation works, and despite the ubiquity of citrus-fruit consumption, these jets had not been previously studied,” Dickerson said. “Nature is our greatest inspiration for tackling real-world problems.”
The team’s findings are published in today’s Proceedings from the National Academy of Sciences.
Florida’s fruit is complex. Its hard outer layer protects the fruit, and a white spongy layer just below the skin has microscopic reservoirs of oil in hidden pockets. The spongy material absorbs impact, but when squeezed to a critical pressure it pushes up and tears open a minute section of the hard outer-layer to spray its fragrant stream. These microjets are small but fast, exiting their cavities at 22 mph on average by accelerating 5,000 Gs, which is equivalent to about 1,000 times the force astronauts feels at launch.
“There are several potential applications,” Smith said. “For example, for asthmatics, you could have a small slice of material which would aerosolize emergency medication that you currently find in expensive, multi-use inhalers. This approach may be less expensive and biodegradable.”
An orange peel releases an oily substance, and the dynamics should hold for other types of liquids, the researchers said.
But there’s still some research needed before putting the orange peel approach to work delivering medication.
“First, we need to work out sizes and proportions,” Dickerson said. “It’s important to understand exactly how the microjets work and how to tune their stability for medical applications. The size of droplets and the amount of medication they carry is critical. We’ve got a ways to go before applications can be explored.”
But when that happens, the possibilities are only limited by the imagination.
“Imagine a self-diagnosing bridge,” Dickerson said. “It would have an orange-like skin layer and when you were approaching material failure, you would get a preventative warning, a color change perhaps.”
Dickerson, a fluid-dynamic expert, is making a career of studying nature. He’s already published several papers looking at what can be learned from the proverbial wet-dog shake and how mosquitos survive raindrop collisions. Studying the shake helps us understand how to self-dry large surfaces such as solar panels. And studying how mosquitos survive rain could help create strategies for combating the disease-carrying insects.
“Few labs nationally do this type of research,” Smith said. “That’s one of the reasons I came to UCF to do my graduate work. This is exciting stuff. Nature has had billions of years to get the engineering principles right and I get to look at them, figure them out and then play with them to solve problems. That’s pretty exciting!”
The Latest on: Drug delivery
via Google News
The Latest on: Drug delivery
- Insights on the Worldwide Pharmaceutical Drug Delivery Market to 2026 - Opportunity Analysis and Industry Forecast - ResearchAndMarkets.comon June 2, 2020 at 9:15 am
According to this report the global pharmaceutical drug delivery system market was valued at $1 billion in 2018, and is expected to reach $2 billion by 2026, registering a CAGR of 4.7% from 2019 to ...
- Coronavirus Impact on Advanced Parenteral Drug Delivery Devices Marketon June 2, 2020 at 7:41 am
You will get latest updated report as per the COVID-19 Impact on this industry. Our updated reports will now feature detailed analysis that will help you make critical decisions. Market Research ...
- Drug Unit, Albany police halt drug deliveryon June 2, 2020 at 7:03 am
Uniform officers with the Albany Police Department notified the Albany-Dougherty Drug Unit Saturday after getting a call that a large quantity of marijuana was at the Fed-Ex location ...
- Global Pharmaceutical Drug Delivery Industry (2019 to 2026) - by Route of Administration and Applicationon June 2, 2020 at 6:41 am
The "Pharmaceutical Drug Delivery Market by Route of Administration and Application: Global Opportunity Analysis and Industry Forecast, 2019-2026" report has been added to ResearchAndMarkets.com's ...
- Drug Delivery Devices Market Size, Industry Analysis, Product Sales, Revenue, Outlook And Forecast Report To 2025on June 2, 2020 at 6:33 am
Drug Delivery Devices Market unveils a succinct analysis of the market size, regional spectrum and revenue forecast about the market. Furthermore, the report points out major challenges and latest ...
- Nasal Drug Delivery Market to Exhibit 7.3% CAGR; Increasing Prevalence of Asthma and COPD will Drive Market, projects Fortune Business Insights™on June 2, 2020 at 1:05 am
Pune, June 02, 2020 (GLOBE NEWSWIRE) -- The global Nasal Drug Delivery Market size is prognosticated to reach USD 73.84 billion by 2026 attributable to the increasing number of the patient population ...
- Connected Drug Delivery Devices Market 2020 – 2026, Details in Relation to the Value, Supply Chain Analysis and Recent Technological Developmentson June 2, 2020 at 1:04 am
The global “connected drug delivery devices” market size is projected to reach USD 4,062.7 million by 2026, exhibiting a CAGR of 35.4% during the forecast period. However, the market size was USD ...
- Free, driverless prescription drug delivery coming to Houston with Nuroon June 1, 2020 at 4:34 pm
HOUSTON, Texas -- The latest partnership from California-based Nuro, which has a fleet of driverless vehicles in Houston, means prescription drug delivery to certain parts of Houston. Rhode ...
- New research offers hope for a way through the blood-brain barrier, ‘the final frontier for drug delivery’on June 1, 2020 at 4:41 am
A duo of preclinical studies recently demonstrated a new way to ferry medicines past the blood-brain barrier. And other research is on the way.
via Bing News