Bartenders and cooks have long recognized the value of an orange twist, but thanks to researchers at the University of Central Florida, squeezing oranges may give us a new way to deliver medicine or to detect bridge failures before they happen.
Engineering Assistant Professor Andrew K. Dickerson and graduate student Nicholas M. Smith have figured out the mechanics of how oranges release that thin stream of fragrant oil when squeezed. They characterized the orange peels’ structure and figured out the role the layers have to create the microjet dynamic. By mimicking nature’s mechanism of an orange layer, pharmaceutical companies may be able to develop a less expensive and less complex way to deliver airborne medication.
“We study natural systems to mathematically characterize how creation works, and despite the ubiquity of citrus-fruit consumption, these jets had not been previously studied,” Dickerson said. “Nature is our greatest inspiration for tackling real-world problems.”
The team’s findings are published in today’s Proceedings from the National Academy of Sciences.
Florida’s fruit is complex. Its hard outer layer protects the fruit, and a white spongy layer just below the skin has microscopic reservoirs of oil in hidden pockets. The spongy material absorbs impact, but when squeezed to a critical pressure it pushes up and tears open a minute section of the hard outer-layer to spray its fragrant stream. These microjets are small but fast, exiting their cavities at 22 mph on average by accelerating 5,000 Gs, which is equivalent to about 1,000 times the force astronauts feels at launch.
“There are several potential applications,” Smith said. “For example, for asthmatics, you could have a small slice of material which would aerosolize emergency medication that you currently find in expensive, multi-use inhalers. This approach may be less expensive and biodegradable.”
An orange peel releases an oily substance, and the dynamics should hold for other types of liquids, the researchers said.
But there’s still some research needed before putting the orange peel approach to work delivering medication.
“First, we need to work out sizes and proportions,” Dickerson said. “It’s important to understand exactly how the microjets work and how to tune their stability for medical applications. The size of droplets and the amount of medication they carry is critical. We’ve got a ways to go before applications can be explored.”
But when that happens, the possibilities are only limited by the imagination.
“Imagine a self-diagnosing bridge,” Dickerson said. “It would have an orange-like skin layer and when you were approaching material failure, you would get a preventative warning, a color change perhaps.”
Dickerson, a fluid-dynamic expert, is making a career of studying nature. He’s already published several papers looking at what can be learned from the proverbial wet-dog shake and how mosquitos survive raindrop collisions. Studying the shake helps us understand how to self-dry large surfaces such as solar panels. And studying how mosquitos survive rain could help create strategies for combating the disease-carrying insects.
“Few labs nationally do this type of research,” Smith said. “That’s one of the reasons I came to UCF to do my graduate work. This is exciting stuff. Nature has had billions of years to get the engineering principles right and I get to look at them, figure them out and then play with them to solve problems. That’s pretty exciting!”
The Latest on: Drug delivery
via Google News
The Latest on: Drug delivery
- Pfizer Spinout SpringWorks, Migraine Drug Firm Satsuma Prep IPOson August 16, 2019 at 5:55 pm
Satsusma’s drug-device product consists of a dry powder formulation of DHE that comes prefilled in a single-use nasal delivery device. The company licensed the technology behind the combo from ...
- Global Topical Drug Delivery Market Report 2019-2024 - ResearchAndMarkets.comon August 16, 2019 at 8:58 am
The "Topical Drug Delivery Market by Type (Semisolids, Liquids, Solids, Transdermal Products), Route (Dermal, Ophthalmic, Rectal, Vaginal, Nasal), Facility of Use (Homecare, Hospital, Burn Center) - ...
- 2019 Liposome Drug Delivery Market | Competitive Landscape, Revenue, Opportunities and Challenges, Future Trends and Forecast till 2028on August 16, 2019 at 6:23 am
Aug 16, 2019 (Reporthive Research via COMTEX) -- Liposome Drug Delivery Market research report covers market share, size, CAGR, industry analysis, market strategy, statistical analysis, sales, revenue ...
- Transdermal Drug Delivery Market Demand Likely to Foster by Growth in Chronic Disease Prevalence by 2024on August 16, 2019 at 2:41 am
Aug 16, 2019 (AmericaNewsHour) -- A recently published report by Research Nester titled "Global Transdermal Drug Delivery Market: Global Future Outlook (2016-2024) Demand Analysis & Opportunity ...
- Nanoscale 'glass' bottles could enable targeted drug deliveryon August 15, 2019 at 5:22 am
Tiny silica bottles filled with medicine and a special temperature-sensitive material could be used for drug delivery to kill malignant cells only in certain parts of the body, according to a ...
- Charcoal-based drug delivery system improves efficacy of common herpes drugon August 14, 2019 at 1:54 pm
A study led by researchers from the University of Illinois at Chicago has found that combining acyclovir—a commonly prescribed topical herpes medication—with particles of activated carbon ...
- Nasal Drug Delivery Market MEA to Reach a Predicted Valuation of USD 1.59 Billion by 2022, Asserts Market Research Futureon August 13, 2019 at 2:45 am
The MEA nasal drug delivery market was analyzed by Market Research Future (MRFR) and it was projected that a healthy CAGR of 8.1% will be attained by the market over the forecast period of 2015 to ...
- Global Cardiovascular Drug Delivery Markets to 2028 by Routes of Drug Delivery, Formulations and Applications to Various Diseaseson August 12, 2019 at 7:28 am
DUBLIN, Aug. 12, 2019 /PRNewswire/ -- The "Cardiovascular Drug Delivery - Technologies, Markets & Companies" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering.
- Global Central Nervous System Diseases Drug Delivery Research Report 2019 - ResearchAndMarkets.comon August 12, 2019 at 4:43 am
The "Drug Delivery in Central Nervous System Diseases - Technologies, Markets & Companies" report from Jain PharmaBiotech has been added to ResearchAndMarkets.com's offering. The delivery of drugs to ...
via Bing News