Orally administered material temporarily coats the intestine, reduces blood sugar spikes in preclinical study
Over the last decade, bariatric surgeons have made strides in performing weight loss surgery that not only reverses obesity but can also reverse type 2 diabetes in patients with both conditions. Despite dramatic improvements in quality of life and diabetes remission, the number of patients who pursue surgery remains relatively low, according to Ali Tavakkoli, MD, co-director of the Center for Weight Management and Metabolic Surgery at BWH. This prompted a collaboration between Tavakkoli and Brigham and Women’s Hospital researchers to find a less invasive but equally effective treatment for reversing type 2 diabetes, one that can offer the same benefits as surgery but that may have wider appeal and application. In a paper published this week in Nature Materials, the team reports on results of a preclinical study in which an oral agent was administered in rats to deliver a substance that could temporarily coat the intestine to prevent nutrient contact with the lining in the proximal bowel and avoid post-meal spikes in blood sugar.
“We envision a pill that a patient can take before a meal that transiently coats the gut to replicate the effects of surgery,” said co-senior author Jeff Karp, PhD, a bioengineer and principal investigator at BWH. “Over the last several years, we’ve been working with our surgical colleagues on this idea and have developed a material that meets an important clinical need.”
The team members searched for a starting material that would have just the right properties to adhere to the small intestine and then dissolve within a matter of hours. They selected a substance known as sucralfate, an FDA-approved drug that is used in the treatment of gastrointestinal ulcers. The team further engineered the substance into a novel material that can coat the lining of the intestine without requiring activation by gastric acid. The engineered compound, referred to as LuCI (Luminal Coating of the Intestine), can be made into a dry powdered form that can be encapsulated as a pill.
“What we’ve developed here is essentially, ‘surgery in a pill,'” said co-lead author Yuhan Lee, PhD, a materials scientist in the BWH Division of Engineering in Medicine. “We’ve used a bioengineering approach to formulate a pill that has good adhesion properties and can attach nicely to the gut in a preclinical model. And after a couple of hours, its effects dissipate.”
The team found that once in the intestine of rats, LuCI can coat the gut, forming a thin barrier that alters nutrient contact and lowers blood glucose response after a meal. After a meal, blood sugar levels rise and can stay elevated over time. However, one hour after LuCI was administered to the rats, the response to glucose was lowered by 47 percent. The team found that this response was temporary, and after three hours, the effect essentially disappeared.
The team is now testing the effect of short- and long-term use of LuCI in diabetic and obese rodent models. They also plan to advance some of their pilot studies showing that LuCI can be used to deliver drugs, including proteins directly to the gastrointestinal tract.
“Gastric bypass is one of the best studied surgeries in the world, and we know that it can lead to many benefits including positive effects for blood pressure, sleep apnea and certain forms of cancer, and a remarkably fast and weight-independent improvement in diabetes,” said Tavakkoli, co-senior author of the study. “Having a transient coating that could mimic the effects of surgery would be a tremendous asset for patients and their care providers.”
Receive an email update when we add a new TYPE 2 DIABETES article.
The Latest on: Type 2 diabetes
via Google News
The Latest on: Type 2 diabetes
- Health Authorities Now Suggest Diabetes May Be Reversed Naturally on December 17, 2018 at 1:16 am
It is worth mentioning diabetes is the seventh top cause of death in the country. In 2015, it accounted for more than 250,000 deaths. Experts warn that type 2 diabetes can result in many health ... […]
- Diabetes type 2 - the ‘strange’ superfood that could prevent high blood sugar on December 16, 2018 at 11:56 pm
Diabetes is caused by the pancreas not producing enough of the hormone insulin, or the body not reacting to insulin. Without enough insulin, the body struggles to convert sugar in the blood into useab... […]
- Record 169 UK patients a week get diabetes-related amputations on December 16, 2018 at 11:00 pm
About 90% of diabetes patients in the UK have type 2 diabetes. Photograph: Ian Hooton/Getty Images/Science Photo Library RF A record 169 people a week are having to undergo amputations as a result of ... […]
- 1 in 7 people with diabetes test blood sugar too often on December 16, 2018 at 4:05 pm
For more than 29 million Americans with type 2 diabetes, testing their blood sugar is just part of daily life. But a new study suggests that some of them test more often than they need to. Fourteen pe... […]
- Link Between Type 1 Diabetes and Psychiatric Comorbidities in Children on December 14, 2018 at 5:45 pm
Children with higher HbA1c levels had the highest risk of developing a disorder within the first 2 years after diagnosis, but this leveled out again after 15–20 years with type 1 diabetes. The mean Hb... […]
- Effect of Elevated Triglycerides on Glycemic Management by Patients with Type 2 Diabetes on December 14, 2018 at 5:45 pm
Study attempts to determine association between elevated triglyceride levels and achieving glycemic goals for those with insulin-treated diabetes. Type 2 diabetes is becoming increasingly prevalent in ... […]
- Many People With Type 2 Diabetes May Test Their Blood Sugar More Than Needed on December 14, 2018 at 11:25 am
Some people with type 2 diabetes are instructed to test their blood sugar levels on a regular basis, but a new study suggests too many people test more often than necessary. The study, published Decem... […]
- Does Diabetes Damage Brain Health? on December 14, 2018 at 6:17 am
FRIDAY, Dec. 14, 2018 (HealthDay News) -- Diabetes has been tied to a number of complications such as kidney disease, but new research has found that older people with type 2 diabetes can also have mo... […]
- "Happy Diabetic" Chef on Type 2 Diabetes and His Passion for Food on December 14, 2018 at 3:11 am
We're thrilled to connect with Robert Lewis in Iowa, a professional chef for four decades who also happens to be living with type 2 diabetes since his early 40s. He's had an impressive career in the f... […]
via Bing News