An operation that targets the nerves connected to the kidney has been found to significantly reduce blood pressure in patients with hypertension, according to the results of a clinical trial led in the UK by Queen Mary University of London and Barts Health NHS Trust, and supported by the National Institute for Health Research (NIHR).
If the findings are confirmed in more extensive clinical trials, the surgery could offer hope to patients with high blood pressure who do not respond to drugs, and are at increased risk of cardiovascular diseases, including stroke and heart attack.
The international clinical trial, carried out from 2017 to 2018 at St Bartholomew’s Hospital in the UK by the NIHRBarts Biomedical Research Centre, tested a one-hour operation called ‘renal denervation’, which uses ultrasound energy to disrupt the nerves between the kidneys and the brain that carry signals for controlling blood pressure.
Significant reduction in blood pressure
146 patients in the United States, France, Germany, the Netherlands, Belgium and the United Kingdom were randomised to receive either renal denervation or a ‘sham procedure’ – the surgical equivalent of a placebo. Patients also remained off blood pressure medications for two months unless specified blood pressure levels were exceeded.
After two months, the renal denervation group experienced an 8.5 mm Hg reduction in blood pressure, which was a 6.3 mm Hg greater reduction compared with the sham group.
More than 66 per cent of subjects treated with renal denervation demonstrated a 5 mm Hg or greater reduction in blood pressure, compared with 33 per cent in the sham group.
No major adverse events were reported in either group, and the blood pressure lowering effect of renal denervation was consistent across sex and ethnicity.
An alternative to lifelong medications
UK Principal Investigator Dr Melvin Lobo from Queen Mary’s William Harvey Research Institute and Barts Health NHS Trust said: “These results leave us clinicians in no doubt that this ultrasound-based therapy works to improve blood pressure control – at least in the short term. Further larger trials will be needed to confirm the efficacy and safety of the technology, but we hope that they could lead to renal denervation therapy being offered as an alternative to lifelong medications for hypertension.”
The study has limitations including the short follow-up time of two months. This was done for safety reasons to minimise the duration of patients being off antihypertensive medications. Longer follow-up of this trial and additional numbers of treated patients will be necessary to provide greater assurance of safety and to exclude rare adverse events.
The Latest on: Hypertension
via Google News
The Latest on: Hypertension
- Morning Rounds: What you need to know about hypertension on March 6, 2019 at 12:00 pm
MISSOULA – We answer your medical questions every Wednesday on Montana This Morning during Morning Rounds. If you have a question that you’d like us to answer, just send us an email at ... […]
- First-Ever Study: Grounding Patients with Hypertension Improves Blood Pressure on March 6, 2019 at 9:31 am
WHITTIER, Calif., March 6, 2019 /PRNewswire/ -- A novel study by a Southern California cardiologist has shown for the first time that Planet Earth's own natural energy has the potential to help reduce ... […]
- Hypertension-related changes may occur earlier in young women with family history on March 6, 2019 at 6:24 am
New research suggests that young women with a family history of high blood pressure (hypertension) have decreased baroreflex function, which may increase their risk for hypertension later in life. […]
- High blood pressure - the painful hypertension symptom that could lead to sudden death on March 6, 2019 at 12:03 am
High blood pressure is a common condition that affects more than 25 per cent of all adults in the UK. It’s could be caused by eating an unhealthy diet, or by not doing enough regular exercise, accordi... […]
- What Causes Ocular Hypertension? on March 5, 2019 at 6:11 pm
The pressure inside the eyeball is called intraocular pressure. In normal physiological condition, fluids enter the eyeball to supply nourishment and maintain the shape of the eye. Sometimes, a dysfun... […]
- ‘Elders in cities prone to hypertension’ on March 5, 2019 at 9:21 am
Older Indians living in cities are more likely to suffer from hypertension as compared to their rural counterparts, states a study published in the Journal of the American Society of Hypertension. The ... […]
- Dietary Fatty Acids Raise Hypertension Risk In Diabetics on March 4, 2019 at 9:45 pm
AsianScientist (Mar. 5, 2019) – In a study published in the journal Nutrients, scientists in Japan have shown that while dietary intake of n-6 fatty acids can lower the risk of hypertension in healthy ... […]
- Are you a ‘walking time bomb’ with untreated hypertension? on March 4, 2019 at 1:43 pm
Last week, various specialists in the treatment of hypertension and its complications gathered for the 24th joint annual convention of the Philippine Hypertension Society (PSH) and the Philippine ... […]
- High blood pressure - the fruit juice you should drink every day to prevent hypertension on March 3, 2019 at 11:56 pm
High blood pressure is a common condition that affects more than a quarter of all adults in the UK. It could be caused by eating an unhealthy diet, or by not doing enough exercise, according to the NH... […]
via Bing News