Our bodies are extremely efficient at storing fat from food into our fat tissue. In a new study, researchers from the University of Copenhagen have managed to completely block the development of obesity.
The researchers deleted an enzyme and made it impossible for mice to increase their amount of fat tissue, despite the mice eating an extremely fatty diet. They are hoping the findings will open new avenues for better treatment of obesity.
But today, where many of us have constant access to high calorie foods, our body’s impressive ability to convert food into fat has, ironically, become problematic. Consequently, the number of overweight people worldwide is skyrocketing, leading to large health consequences for both the individual and society.
However, as part of a new study, researchers at the University of Copenhagen have now managed to inhibit the body’s ability to store fat. They genetically delete the enzyme NAMPT in fat tissue of mice, and this renders the animals completely resistant to becoming overweight or obese, even on a very fatty diet.
‘We gave the mice a diet that more or less corresponds to continuously eating burgers and pizza. Still, it was impossible for them to expand their fat tissue. Our ultimate goal is that by understanding these fundamental underpinnings of how we become obese, we can apply our finding to the development of novel treatment strategies for metabolic disease,’ says Karen Nørgaard Nielsen, first author on the publication and a Ph.D. student at the Novo Nordisk Foundation Center for Basic Metabolic Research.
High-Fat Food, Same Weight
The findings are in line with results obtained from humans. Several studies have shown that the presence of large amounts of the enzyme NAMPT in blood and in stomach fat tissue is significantly connected with being overweight or obese. However, this study provides the first evidence that NAMPT is absolutely required to become overweight or obese and that lack of NAMPT in fat tissue fully protects against obesity.
In the University of Copenhagen study, the researchers compared how normal mice and mice lacking NAMPT in fat tissue gained weight when given either high-fat food or a healthier, lower-fat diet. When on the healthy diet, there was no difference in body weight or the amount of fat between the normal mice and the mice lacking NAMPT.
However, when the mice were given high-fat food, the control mice became very obese, yet the mice lacking NAMPT gained no more weight from high-fat food than when they were on the healthier diet. In addition, the mice lacking NAMPT maintained better control of blood glucose than normal mice when eating high-fat food.
Contradicts the General View
The result challenges the general view of NAMPT, which is largely seen as an enzyme that should be boosted for therapeutic purposes.
‘NAMPT appears to increase the metabolic functionality of almost every tissue in the body in which it has been studied. For example, there are indications that the liver and skeletal muscle may benefit from increased NAMPT activity. We similarly find that NAMPT is critical for fat tissue function. Unfortunately, that function is efficiently storing fat. NAMPT in fat tissue was likely once an extraordinary benefit to our ancestors but in today’s society full of high-fat, calorically-dense foods, it may now pose a liability’, says Associate Professor Zachary Gerhart-Hines from the Novo Nordisk Foundation Center for Basic Metabolic Research and corresponding author on the study.
He does not necessarily believe that generally decreasing NAMPT is a viable treatment strategy in humans. There would be too great a risk for potentially harmful consequences in other tissues of the body.
However, he suggests that this study may pave the way for more research into how NAMPT is linked to the storage of fat from the food we eat. By learning biologically how we become obese in the first place, he hopes that it will eventually be possible to target one of the underlying mechanisms in humans to treat obesity and metabolic disease.
The Latest on: Obesity
via Google News
The Latest on: Obesity
- Editorial: Hawaii is healthiest, but obesity a concern on December 18, 2018 at 2:05 am
In this year’s round of America’s Health Rankings, Hawaii emerged as the overall top state, based on assessment of a total of 35 core health-related behaviors, community and environment issues, policy ... […]
- Excess Body Weight Responsible For 3.9 Percent Cancer Worldwide: 5 Tips To Manage Obesity on December 18, 2018 at 1:43 am
Obesity is emerging to be one of the top health concerns around the world. If the findings of a latest study are to be believed, excess body weight is said to be responsible for 3.9 percent of cancer ... […]
- Anxiety, Depression May Take Same Toll on Health as Obesity and Smoking on December 18, 2018 at 1:16 am
Anxiety and depression can be equally dangerous to your health just like smoking and obesity, reports a new study. The findings of the study are published in the journal Health Psychology. An annual p... […]
- Obesity Causes Almost 4 Percent of Cancer Cases Worldwide on December 18, 2018 at 12:25 am
A recent study used publicly available data to estimate regional and global trends of obesity for the past four decades and subsequently, established a link between high body mass index (BMI) and incr... […]
- Treating obesity without going under the knife on December 17, 2018 at 11:12 pm
More than one in 10 people around the world are classified as obese, defined as having a BMI (body-mass index) of 30 or higher. In the United States, that number jumps dramatically to one out of every ... […]
- Link Between Poverty and Obesity A Recent Phenomenon on December 17, 2018 at 9:12 pm
It’s a well-established fact that poor people in America are disproportionately affected by obesity, but a new study reveals that this relationship is only about 30 years old. “We found that ... […]
- Depression And Anxiety May Damage Health As Much As Smoking And Obesity, Suggests Study on December 17, 2018 at 8:40 pm
People suffering from anxiety and depression may be at significantly higher risk for major health conditions like heart disease, according to new research, perhaps at levels comparable to smoking and ... […]
- Incredible battery-free implant battles obesity by suppressing appetite on December 17, 2018 at 6:02 pm
A remarkable new implantable device developed by engineers at University of Wisconsin–Madison promises a new way to battle obesity. By gently stimulating a nerve that links the stomach to the ... […]
- Depression, anxiety may take same toll on health as smoking and obesity on December 17, 2018 at 12:25 pm
An annual physical typically involves a weight check and questions about unhealthy habits like smoking, but a new study from UC San Francisco suggests health care providers may be overlooking a ... […]
via Bing News