Nonsurgical technique allows them to turn doorknobs, open water bottles for the first time in years
he ability to perform simple daily tasks can make a big difference in people’s lives, especially for those with spinal cord injuries. A UCLA-led team of scientists reports that six people with severe spinal cord injuries — three of them completely paralyzed — have regained use of their hands and fingers for the first time in years after undergoing a nonsurgical, noninvasive spinal stimulation procedure the researchers developed.
At the beginning of the study, three of the participants could not move their fingers at all, and none could turn a doorknob with one hand or twist a cap off a plastic water bottle. Each of them also had great difficulty using a cellphone. After only eight researcher-led training sessions with the spinal stimulation, all six individuals showed substantial improvements. The study participants had chronic and severe paralysis for more than one year, and some for more than 10 years.
From before the first session to the end of the last session, the participants improved their grip strength.
“About midway through the sessions, I could open my bedroom door with my left hand for the first time since my injury and could open new water bottles, when previously someone else had to do this for me,” said Cecilia Villarruel, one of the participants, whose injury resulted from a car accident 13 years earlier. “Most people with a spinal cord injury say they just want to go to the bathroom like a normal person again,” she said. “Small accomplishments like opening jars, bottles and doors enable a level of independence and self-reliance that is quite satisfying, and have a profound effect on people’s lives.”
In addition to regaining use of their fingers, the research subjects also gained other health benefits, including improved blood pressure, bladder function, cardiovascular function and the ability to sit upright without support.
“Within two or three sessions, everyone started showing significant improvements, and kept improving from there,” said the study’s lead author, UCLA research scientist Parag Gad.
“After just eight sessions, they could do things they haven’t been able to do for years,” said V. Reggie Edgerton, senior author of the research and a UCLA distinguished professor of integrative biology and physiology, neurobiology and neurosurgery.
This is the largest reported recovery of the use of hands that has been reported in patients with such severe spinal cord injuries, Edgerton said.
The researchers placed electrodes on the skin to stimulate the circuitry of the spinal cord. They call their method “transcutaneous enabling motor control,” or tEmc. In the stimulation, electrical current is applied at varying frequencies and intensities to specific locations on the spinal cord.
In the training sessions, the participants squeezed a small gripping device 36 times (18 times with each hand) and held their grip for three seconds; the researchers measured the amount of force they used. The training consisted of two sessions a week over four weeks; the eight sessions each lasted about 90 minutes.
“The combination of spinal stimulation plus training with the hands allows them to regain the lost function,” Gad said. They were less dependent on their caregivers, and could feed and dress themselves, he added.
Two of the six returned to Edgerton’s laboratory 60 days after the training ended and maintained their grip strength; they could turn a doorknob with one hand, twist off a bottle cap and use a fork with one hand. (The four others did not return to the laboratory. The research subjects live in New York, Minnesota and elsewhere.)
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