A KAIST team presented a highly customizable neural stimulation method. The research team developed a technology that can print the heat pattern on a micron scale to enable the control of biological activities remotely.
The researchers integrated a precision inkjet printing technology with bio-functional thermo-plasmonic nanoparticles to achieve a ‘selective nano-photothermal neural stimulation method.’
The research team of Professor Yoonkey Nam at the Department of Bio and Brain Engineering expects this will serve as an enabling technology for personalized precision neuromodulation therapy for patients with neurological disorders.
The nano-photothermal neural stimulation method uses the thermo-plasmonic effect of metal nanoparticles to modulate the activities of neuronal networks. With the thermo-plasmonic effect, metal nanoparticles can absorb specific wavelength of illuminated light to efficiently generate localized heat. The research team discovered the inhibitory behavior of spontaneous activities of neurons upon photothermal stimulation four years ago. Since then, they have developed this technology to control hyperactive behaviors of neurons and neural circuits, which is often found in neurological disorders such as epilepsy.
In order to overcome the limitation on the spatial selectivity and resolution of the previously developed nano-photothermal method, the team adopted an inkjet printing technology to micro pattern the plasmonic nanoparticles (a few tens of microns), and successfully demonstrated that the nano-photothermal stimulation can be selectively applied according to the printed patterns.
The researchers applied a polyelectrolyte layer-by-layer coating method to printing substrates in a way to improve the pattern fidelity and achieve the uniform assembly of nanoparticles. The electrostatic attraction between the printed nanoparticles and the coated printing substrate also helped the stability of the attached nanoparticles. Because the polyelectrolyte coating is biocompatible, biological experiments including cell culture are possible with the technology developed in this work.
Using printed gold nanorod particles in a few tens of microns resolution over a several centimeters area, the researchers showed that highly complex heat patterns can be precisely formed upon light illumination according to the printing image.
Lastly, the team confirmed that the printed heat patterns can selectively and instantaneously inhibit the activities of cultured hippocampal neurons upon near-infrared light illumination. Because the printing process is applicable to thin and flexible substrates, the technology can be easily applied to implantable neurological disorder treatment devices and wearable devices. By selectively applying the heat patterns to only the desired cellular areas, customized and personalized photothermal neuromodulation therapy can be applied to patients.
“The fact that any desired heat patterns can be simply ‘printed’ anywhere broadens the applicability of this technology in many engineering fields. In bioengineering, it can be applied to neural interfaces using light and heat to modulate physiological functions. As another engineering application, for example, printed heat patterns can be used as a new concept of anti-counterfeit applications,” said the principal investigator, Yoonkey Nam at KAIST.
The Latest on: Nano-photothermal neural stimulation
via Google News
The Latest on: Nano-photothermal neural stimulation
- Black patients with esophageal cancer less likely to receive surgery for early-stage diseaseon June 25, 2020 at 3:07 pm
Black patients with esophageal cancer are at a higher risk of death compared to white patients. Although many reasons have been suggested for this, few have given physician actionable information.
- Treating mental illness needs the same level of compassion as treating canceron June 25, 2020 at 3:00 pm
Telling my little girl she had cancer was one of the most difficult things I’ve done in my life. Pediatric cancer destroys childhood innocence. I can still close my eyes and see the images: the clinic ...
- Loose Women's Janet Street-Porter diagnosed with skin canceron June 25, 2020 at 2:45 pm
Porter has revealed that she's been diagnosed with a form of skin cancer. The panellist said on the show that she originally thought she'd been bitten on the nose by a mosquito over Christmas when she ...
- Missouri State Highway Patrol K-9 says goodbye after terminal cancer diagnosison June 25, 2020 at 2:27 pm
The Missouri State Highway Patrol is mourning after a lifelong service member in the state was diagnosed with terminal cancer. K-9 Cuba went on his final walk Monday, according to a Facebook post from ...
- Scientists study how magnetic nanoparticles affect cancer cells in the liveron June 25, 2020 at 2:20 pm
Scientists from the Immanuel Kant Baltic Federal University (IKBFU) and National University of Science and Technology "MISiS" have studied how magnet nanoparticles affect cancer cells in the human ...
- Cancer Immunotherapy Tied to Severe COVID-19 Outcomeson June 25, 2020 at 1:22 pm
Cancer patients receiving immunotherapy were at increased risk for severe outcomes from COVID-19, according to retrospective findings from Memorial Sloan Kettering Cancer Center in New York City.
- This man is on a mission to raise awareness about male breast canceron June 25, 2020 at 11:19 am
When Michael Singer was diagnosed with breast cancer in his 50s, he felt alone. "My head exploded," he told In The Know of his diagnosis. "Because I had never heard of it. I had never heard of men ...
- K-9 state trooper diagnosed with terminal cancer euthanizedon June 25, 2020 at 9:36 am
A Missouri State Highway Patrol trooper K-9 was laid to rest Monday after being diagnosed with terminal cancer.
- Impact of a natural disaster on access to care and biopsychosocial outcomes among Hispanic/Latino cancer survivorson June 25, 2020 at 4:37 am
Hurricane Maria (HM) and its aftermath lead to widespread devastation on the island, including the collapse of the healthcare system. Medically fragile populations, such as cancer survivors, were ...
via Bing News