The results could open the door to new targeted therapies for this debilitating disease in the future
In the largest study of its kind, nine novel genes for osteoarthritis have been discovered by scientists from the Wellcome Sanger Institute and their collaborators. Results of the study, published today (19 March) in Nature Genetics, could open the door to new targeted therapies for this debilitating disease in the future.
Almost nine million people in the UK suffer from osteoarthritis, a degenerative joint disease in which a person’s joints become damaged, stop moving freely and become painful. Osteoarthritis is the most prevalent musculoskeletal disease and a leading cause of disability worldwide.
There is no treatment for osteoarthritis. The disease is managed with pain relief and culminates in joint replacement surgery, which has variable outcomes.
In the largest study of its kind, scientists from the Wellcome Sanger Institute and their collaborators* investigated the genetics behind osteoarthritis, as well as the diseases and traits that are linked to it.
To understand more about the genetic basis of osteoarthritis, the team studied 16.5 million DNA variations from the UK Biobank resource. Following combined analysis in up to 30,727 people with osteoarthritis and nearly 300,000 people without osteoarthritis in total – the controls – scientists discovered nine new genes that were associated with osteoarthritis, a significant result for this disease.
“Osteoarthritis is challenging to study because the disease can vary among people, and also between the different joints affected, for example knee, hip, hand and spine. Using data from the UK Biobank resource, we have undertaken the largest genetic study of osteoarthritis to date and uncovered nine new genes associated with the disease.”
Professor Eleftheria Zeggini, senior author from the Wellcome Sanger Institute
Researchers then investigated the role of the nine new genes in osteoarthritis, by studying both normal cartilage and diseased cartilage from individuals who had a joint replacement.
The team looked for genes that were active in the progression of the disease by extracting the relevant cells from healthy and diseased tissue, studying the levels of proteins in the tissue and sequencing the RNA – the messenger that carries instructions from DNA for controlling the production of proteins.
Of the nine genes associated with osteoarthritis, researchers identified five genes in particular that differed significantly in their expression in healthy and diseased tissue. The five genes present novel targets for future research into therapies.
“These results are an important step towards understanding the genetic causes of osteoarthritis and take us closer to uncovering the mechanism behind the disease. Once we know that, it opens the door to developing new therapies for this debilitating disease.”
Ms Eleni Zengini, joint first author from the University of Sheffield and Dromokaiteio Psychiatric Hospital in Athens
The team also explored genetic correlations between osteoarthritis and obesity, bone mineral density, type 2 diabetes, and raised blood lipid levels.
Researchers applied a statistical technique known as causal inference analysis to uncover which traits and diseases cause osteoarthritis, and which do not.
Within the limits of their study, scientists discovered that type 2 diabetes and high levels of lipids in the blood do not have causal effects on osteoarthritis, but reaffirm that obesity does.
“Using genetic data, we have shown that type 2 diabetes and increased blood lipid levels do not appear to be on the causal path to osteoarthritis. We also reconfirmed that obesity is on the causal path to osteoarthritis.”
Dr Konstantinos Hatzikotoulas, joint first author from the Wellcome Sanger Institute
“The discovery of these genes is positive news for the 8.5 million people in the UK living with osteoarthritis. People living with this debilitating condition currently have limited treatment options. Meanwhile, they can struggle to do the day-to-day things most of us take for granted, like going to work or getting dressed independently. By revealing how these genes contribute to osteoarthritis, this research could open the door for new treatments to help millions of people live the pain free life they deserve.”
Dr Natalie Carter, Head of research liaison & evaluation at Arthritis Research UK, who did not fund the study
Learn more: New osteoarthritis genes discovered
The Latest on: Osteoarthritis
via Google News
The Latest on: Osteoarthritis
- Osteoarthritis can increase your risk for social isolationon October 16, 2019 at 12:32 am
When older adults become lonely—a condition health professionals call "social isolation"—their health and well-being can suffer. In fact, there may be a link between being socially isolated and ...
- Steroid injections for osteoarthritis more may damage jointson October 15, 2019 at 8:51 pm
Osteoarthritis (OA), also called degenerative joint disease, is the most common chronic condition of the joints. Since the disease is degenerative, it is the single most common cause of disability ...
- Osteoarthritis Therapeutics Market Worth $10.1 Billion by 2024 - Exclusive Report by MarketsandMarkets™on October 15, 2019 at 5:36 am
Osteoarthritis Therapeutics Market Worth $10.1 Billion by 2024 - Exclusive Report by MarketsandMarkets™ PR Newswire CHICAGO, Oct. 15, 2019 CHICAGO, Oct. 15, 2019 /PRNewswire/ -- According to the new ...
- Osteoarthritis Therapeutics Market Worth $10.1 Billion by 2024 - Exclusive Report by MarketsandMarketson October 15, 2019 at 5:31 am
CHICAGO, Oct. 15, 2019 /PRNewswire/ -- According to the new market research report "Osteoarthritis Therapeutics Market by Anatomy (Knee, Hip), Drug Type (NSAIDs, Corticosteroids), Route of ...
- Federal Circuit Decision Delays Generic Osteoarthritis Drugon October 14, 2019 at 2:17 pm
Horizon’s patent claims relate to methods and compositions for treating osteoarthritis, and include a number of U.S. patents, of which claim 10 of U.S. Patent No. 8,546, 450 demonstrates the use of ...
- Osteoarthritis Drugs Market Statistics, Growth Potential, Industry and Analysis 2018-2026on October 14, 2019 at 10:59 am
Oct 14, 2019 (WiredRelease via COMTEX) -- Osteoarthritis is the most common form of arthritis and can adversely impact several joints in the body. The condition primarily affects knees, neck, lower ...
- New Osteoarthritis Treatment Has to Wait Even Longer for FDA Approvalon October 14, 2019 at 7:00 am
In December 2018, the company filed the sNDA seeking to revise the Zilretta product label based on results from an open-label Phase 3b clinical trial, which evaluated repeat administration of Zilretta ...
- PET TALK: Monitoring of equine osteoarthritis crucial, experts sayon October 12, 2019 at 10:00 pm
Osteoarthritis is a progressive disease that compromises the joint health and mobility of many animals. While osteoarthritis is the most common joint disorder for people in the United States, the ...
- Investigational Osteoarthritis Drug Results Mixedon October 10, 2019 at 5:45 am
An injection of the investigational osteoarthritis drug sprifermin (Merck KgaA) into the knee joint every 6 or 12 months resulted in statistically significant improvement in cartilage thickness after ...
via Bing News