A research team at the VIB-KU Leuven Center for Microbiology has developed a novel screening method to identify antimicrobial properties of volatile substances. With this assay, they tested the vapour-phase-mediated activity of 175 essential oils (EOs) and 37 EO components. Approximately half of them proved active against the most drug-resistant type of Candida. In a context of fungi showing increasing drug resistance, these findings may be useful in both medical and agricultural applications.
The research project, led by prof. Patrick Van Dijck, is rooted in the growing problem of antifungal drug resistance. Candida cells, for example, are quickly becoming tolerant to fluconazole, the most-used antifungal drug. Next to exploring experimental new techniques, scientists also seek to repurpose existing substances. Plant essential oils (EOs), metabolites obtained by steam distillation or cold citrus peel pressing, may offer interesting opportunities: they are made up of compounds that help protect the plant against microbial or herbivore attacks.
Identifying EOs and their compounds
In the VIB-KU Leuven Center for Microbiology, Adam Feyaerts gathered a collection of 175 different EOs, constituting a collection of over one thousand different small molecules. The aim was to identify biologically active compounds present in these complex mixtures. They therefore developed a new class of assay that allowed to identify new volatile substances with antifungal activities over a distance.
Prof. Patrick Van Dijck (VIB-KU Leuven): “We screened our whole collection of EOs for vapor-phase mediated antifungal activity against two human fungal pathogens, Candida albicans and Candida glabrata. Interestingly, we found that approximately half of the EOs and their compounds had vapour-phase-mediated activity against bothCandida species. Surprisingly, C. glabrata, the most drug-resistant species of the two was on average even more susceptible. In contrast, none of the currently used antifungals showed any vapour-phase-mediated activity.”
Numerous potential applications
This is now the first simple test to look for the vapor-phase-mediated antimicrobial activity of molecules. The same assay could also be used to test other biological activity. And although these findings still have to be confirmed in clinical trials, potential applications are numerous.
Co-author Adam Feyaerts (VIB-KU Leuven): “Our findings are for instance a starting point for the development of molecules that could also be used in vaporizers. After all, volatiles can access otherwise hard to reach areas. Think of possibilities such as maintaining hygiene in hospitals or treat patients with lung infections. There are agricultural options too, such as preventing post-harvest contamination or protecting crops against pests.”
The Latest on: Antifungal drug resistance
via Google News
The Latest on: Antifungal drug resistance
- Sea Squirt Microbiome Yields Compound Effective against Deadly Strain of Fungal Pathogenon November 20, 2020 at 4:00 am
Newly identified antifungal compound, turbimicin, found to be safe at high doses in mice, and demonstrated a fungal-specific mode of action.
- Invasive Fungal Infection (IFI) Market Size, Share to record considerable growth over 2019-2024 - Industry Newson November 19, 2020 at 2:12 pm
Market Size and Analysis maintains enhanced dynamics and is overshadowed by a top player across the globe. The research report provides Invasive Fungal Infection (IFI) Market Growth and information ...
- Marine bacterium yields promising new antifungalon November 19, 2020 at 11:24 am
A molecule extracted from a bacterium living inside a sea squirt acts as a potent antifungal, even against multidrug-resistant fungal pathogens such as Candida auris, according to Fan Zhang and ...
- Potent new antifungal discovered in the microbiome of marine animalson November 19, 2020 at 11:24 am
A new antifungal compound that is effective against multidrug-resistant fungi has been isolated from bacteria living in filter-feeding marine animals called sea squirts ...
- New effective and safe antifungal isolated from sea squirt microbiomeon November 19, 2020 at 11:03 am
By combing the ocean for antimicrobials, scientists at the University of Wisconsin-Madison have discovered a new antifungal compound that efficiently targets multi-drug-resistant strains of deadly ...
- Safe and Effective Antifungal Gleaned From Sea Squirton November 19, 2020 at 10:20 am
Scientists announced Thursday they have discovered a nontoxic antifungal compound that destroys drug resistant strains of deadly fungi, a discovery that could save millions of lives.
- Spectrum Antimicrobials, Inc. Announces Breakthrough Drug Candidate for Prevention and ...on November 16, 2020 at 6:47 am
Spectrum Antimicrobials, Inc., a subsidiary of Collidion, Inc. announces the development of a novel antiviral drug candidate designed to treat pulmonary infections. SPC-069 is a new class of therapy ...
- €10m. grant given to Israeli researchers studying fungal infectionson November 15, 2020 at 3:19 pm
A €10 million grant was awarded to researchers from Tel Aviv University and Charité – Universitätsmedizin Berlin by the scientific body of the European Commission, the European Research Council (ERC).
- Mycovia Pharmaceuticals Completes Successful Pre-NDA Meeting with FDA for Oteseconazole for the Treatment of Recurrent Vulvovaginal Candidiasison November 12, 2020 at 5:37 am
Mycovia Pharmaceuticals, Inc. ("Mycovia"), an emerging biopharmaceutical company dedicated to recognizing and empowering those living with unmet medical needs by developing novel therapies, today ...
- ERC Synergy project explores causes of drug tolerance in intractable fungal infectionson November 10, 2020 at 4:09 pm
Universitätsmedizin Berlin and Tel Aviv University will study how invasive fungal pathogens are able to evade treatments and develop tolerance to antifungal drugs.
via Bing News