A new birth control pill for men appears to be safe when used daily for a month, with hormone responses consistent with effective contraception, study researchers say.
Their study results, in 83 men, will be presented Sunday at ENDO 2018, the Endocrine Society’s 100th annual meeting in Chicago, Ill.
Like the pill for women, the experimental male oral contraceptive—called dimethandrolone undecanoate, or DMAU—combines activity of an androgen (male hormone) like testosterone, and a progestin, and is taken once a day, said the study’s senior investigator, Stephanie Page, M.D., PhD, professor of medicine at the University of Washington, Seattle, Wash.
“DMAU is a major step forward in the development of a once-daily ‘male pill’,” Page said. “Many men say they would prefer a daily pill as a reversible contraceptive, rather than long-acting injections or topical gels, which are also in development.”
Progress toward a male birth control pill has been stymied because, according to Page, available oral forms of testosterone may cause liver inflammation, and they clear the body too quickly for once-daily dosing, thus requiring two doses a day. However, DMAU contains undecanoate, a long-chain fatty acid, which Page said slows this clearance. DMAU is being developed by the National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, which funded this study.
The study included 100 healthy men, ages 18 to 50 years, and took place at the University of Washington Medical Center and at Harbor-UCLA Medical Center in Torrance, CA (led by co-author Christina Wang, M.D.). The investigators tested three different doses of DMAU (100, 200, and 400 milligrams, or mg) and two different formulations inside the capsules (castor oil and powder). Each dose group included five subjects who were randomly assigned to receive an inactive placebo and another 12 to 15 men who received DMAU. Subjects took the drug or placebo for 28 days once daily with food. DMAU must be taken with food to be effective, Page noted.
A total of 83 men completed the study, including giving blood samples, for hormone and cholesterol testing, on the first and last days of the study.
At the highest dose of DMAU tested, 400 mg, subjects showed “marked suppression” of levels of their testosterone and two hormones required for sperm production. The low levels, Page said, are consistent with effective male contraception shown in longer-term studies.
“Despite having low levels of circulating testosterone, very few subjects reported symptoms consistent with testosterone deficiency or excess,” Page said.
All groups taking DMAU did have weight gain and decreases in HDL (“good”) cholesterol, both of which Page said were mild. All subjects passed safety tests, including markers of liver and kidney function.
“These promising results are unprecedented in the development of a prototype male pill,” Page said. “Longer term studies are currently under way to confirm that DMAU taken every day blocks sperm production.”
The Latest on: Male birth control pill
via Google News
The Latest on: Male birth control pill
- Seattle-area couples test birth control for men on December 18, 2018 at 5:59 am
Page is among a group of UW researchers who have been working on male contraception for decades ... she said. Other birth-control methods for men that are in early trials at UW include a pill that red... […]
- Is Male Birth Control on the Horizon? on December 8, 2018 at 1:41 pm
"Many women cannot use hormonal contraception and male contraceptive methods ... who can choose from a bevy of birth control options, including the pill, a vaginal ring, IUDs, an arm implant ... […]
- Now, a male birth control gel is on its way on December 7, 2018 at 12:49 am
"Male birth control is going to be rubbing a gel on your shoulders?! Nah y'all can swallow a pill every single night, get injections & implants like the rest of us," said one. While other women ... […]
- A new birth-control gel that men rub on their shoulders once a day is being tested in the US on December 5, 2018 at 3:53 pm
But some women can't take birth control pills, and some men want their own reliable way to prevent pregnancies (condoms are only about 85% effective) that doesn't require an irreversible and expensive ... […]
- A Topical Gel Is Being Tested As Birth Control For Men And This Is So Unfair on December 5, 2018 at 12:06 pm
Okay hold the fuck up. Women are presented with the option of taking pills everyday, inserting a circle into their vagina, or implanting a bar into their arm for birth-control. They finally make male ... […]
- Scientists are testing a new male birth control gel, and some people are furious that it seems more 'simple and convenient' than female options on December 4, 2018 at 9:42 am
The pill, for example, can have side effects like nausea, headaches, and breast tenderness, and IUDs require an insertion procedure that many women find painful. "Male birth control is going to be rub... […]
- Would you try this male birth control gel? on December 3, 2018 at 5:04 am
A male form of birth control has been in the works for over a decade now, but 2018 has seen major advancements in the field, first in pill form, and now as a gel. Researchers have officially begun the ... […]
- Researchers testing potential breakthrough for male birth control gel on November 29, 2018 at 4:18 pm
Right now, there's no male birth control pill available. Narula said one reason is because a lot of the research has been left to non-profits and governments. Another issue comes down to biology. "It' ... […]
- Hope for male birth control? Human trials (finally) begin for a GEL that may stop sperm production on November 29, 2018 at 6:49 am
If it works, there may be hope for freedom from the pill for women - but it will likely be years before the male birth control gel could hit the market. […]
via Bing News