As we grow older, our muscular function declines. A new study by researchers at Karolinska Institutet shows how an unexpectedly high number of mutations in the stem cells of muscles impair cell regeneration. This discovery may result in new medication to build stronger muscles even when in old age.
The study is published in Nature Communications.
It has already been established that natural ageing impairs the function of our skeletal muscles. We also know that the number and the activity of the muscles’ stem cells decline with age. However, the reasons for this has not been fully understood. In a new study, researchers at Karolinska Institutet have investigated the number of mutations that accumulate in the muscle’s stem cells (satellite cells).
“What is most surprising is the high number of mutations. We have seen how a healthy 70-year-old has accumulated more than 1,000 mutations in each stem cell in the muscle, and that these mutations are not random but there are certain regions that are better protected,” explains Maria Eriksson, Professor at the Department of Biosciences and Nutrition at Karolinska Institutet.
The protection declines with age
The mutations occur during natural cell division, and the regions that are protected are those that are important for the function or survival of the cells. Nonetheless, the researchers were able to identify that this protection declines with age.
“We can demonstrate that this protection diminishes the older you become, indicating an impairment in the cell’s capacity to repair their DNA. And this is something we should be able to influence with new drugs,” explains Maria Eriksson.
The researchers have benefited from new methods to complete the study. The study was performed using single stem cells cultivated to provide sufficient DNA for whole genome sequencing.
Complex mutational burden
“We achieved this in the skeletal muscle tissue, which is absolutely unique. We have also found that there is very little overlap of mutations, despite the cells being located close to each other, representing an extremely complex mutational burden,” explains the study’s first author, Irene Franco, Postdoc in Maria Eriksson’s research group.
The researchers will now continue their work to investigate whether physical exercise can affect the number of accumulated mutations. Is it true that physical exercise from a young age clears out cells with many mutations, or does it result in the generation of a higher number of such cells?
Can result in new exercise programmes
“We aim to discover whether it is possible to individually influence the burden of mutations. Our results may be beneficial for the development of exercise programmes, particularly those designed for an ageing population,” explains Maria Eriksson.
The Latest on: Muscle stem cells
via Google News
The Latest on: Muscle stem cells
- First dual stem cell therapy brings new hope for cardiac repairon October 29, 2019 at 9:04 am
A research team featuring an expert from City University of Hong Kong (CityU) has developed a novel dual approach for the first time for concurrently rejuvenating both the cardiac muscle and ...
- Is the World Ready for [Checks Notes] Cruelty-Free Zebra Meat?on October 28, 2019 at 2:58 pm
The company's still-complicated-sounding method involves taking stem cells from a living animal, combining them with growth factors that duplicate a cow's natural muscle regeneration process, and then ...
- New University of Washington Center to Produce Stem Cells for Research on Muscle Disorders Such as ALSon October 24, 2019 at 7:03 am
“What the new muscle research center offers patients with these diseases, many of whom are racing against time, is hope,” said Michael Regnier, a professor of bioengineering at UW, in a news release.
- Stem cells in the finding phaseon October 23, 2019 at 8:32 am
Because in normal development, the pluripotent stem cells “differentiate” into mature cells and these are not supposed to change their identity anymore. From a liver cell, only more liver cells arise, ...
- 26-Yr-Old DMD Patient in UP Survives with the Help of Stem Cell Therapyon October 22, 2019 at 11:32 pm
Children suffering from DMD usually die of cardio-respiratory failure. But with stem cell therapy, this patient has not lost muscle power in the last five years, and heart and lung muscles and the ...
- Mending broken hearts with neural crest cellson October 22, 2019 at 5:10 am
Stem cells called neural crest cells emerge from the forming CNS and migrate outward ... As in chicken and mice, the researchers confirmed that some neural crest cells in zebrafish become heart muscle ...
- In a first, 26-yr-old DMD patient in UP survives with stem cell therapyon October 21, 2019 at 11:10 pm
Children, suffering from DMD, usually die of cardio-respiratory failure. But with the stem cell therapy, this patient has not lost muscle power in last five years and heart and lung muscles and the ...
- Harvard researchers grew meat in a lab from cow and rabbit cells. It looks a lot like the real thingon October 21, 2019 at 2:31 pm
Engineers have tinkered with bioengineered meat for years, taking stem cells from animals and growing and multiplying them until they divide and form new muscle tissues. But previous attempts to grow ...
- How Stem Cells Make Decisionson October 21, 2019 at 9:15 am
Or will you commit to becoming part of the tissue that eventually becomes the brain, bone, muscle or gut? This crossroads in the cell cycle has been of particular interest to neuroscientist Kenneth ...
- Stem cell therapy for obesity-induced metabolic disorderson October 21, 2019 at 5:16 am
Fat-tissue-derived specific stem cells could be used to alleviate obesity-induced metabolic disorders, a study reveals 1. Stem cells have the potential to grow into other tissue types such as bone, ...
via Bing News