Human clinical trials could begin as early as next year
A team of researchers at the University of Georgia’s Regenerative Bioscience Center and ArunA Biomedical, a UGA startup company, have developed a new treatment for stroke that reduces brain damage and accelerates the brain’s natural healing tendencies in animal models. They published their findings in the journal Translational Stroke Research.
The research team led by UGA professor Steven Stice and Nasrul Hoda of Augusta University created a treatment called AB126 using extracellular vesicles (EV), fluid-filled structures known as exosomes, which are generated from human neural stem cells.
Fully able to cloak itself within the bloodstream, this type of regenerative EV therapy appears to be the most promising in overcoming the limitations of many cell therapies—with the ability for exosomes to carry and deliver multiple doses—as well as the ability to store and administer treatment. Small in size, the tiny tubular shape of an exosome allows EV therapy to cross barriers that cells cannot.
“This is truly exciting evidence, because exosomes provide a stealth-like characteristic, invisible even to the body’s own defenses,” said Stice, Georgia Research Alliance Eminent Scholar and D.W. Brooks Distinguished Professor in the College of Agricultural and Environmental Sciences. “When packaged with therapeutics, these treatments can actually change cell progression and improve functional recovery.”
Following the administration of AB126, the researchers used MRI scans to measure brain atrophy rates in preclinical, age-matched stroke models, which showed an approximately 35 percent decrease in the size of injury and 50 percent reduction in brain tissue loss—something not observed acutely in previous studies of exosome treatment for stroke.
Outside of rodents, the results were replicated by Franklin West, associate professor of animal and dairy science, and fellow RBC members using a porcine model of stroke—the only one of its kind in the U.S.
Based on these pre-clinical results, ArunA Biomedical plans to begin human studies in 2019, said Stice, who is also chief scientific officer of ArunA Biomedical.
“Until now, we had very little evidence specific to neural exosome treatment and the ability to improve motor function,” said Stice. “Just days after stroke, we saw better mobility, improved balance and measurable behavioral benefits in treated animal models.”
Named as part of the ‘stroke belt’ region, Georgia continues to exceed the national average in stroke deaths, which is the third leading cause of death in the U.S., with more than 140,000 Americans dying each year, according to the Centers for Disease Control and Prevention.
ArunA recently unveiled advances to the company’s proprietary neural cell platform for the production of exosome manufacturing. Today, ArunA’s manufacturing process positions the company to produce AB126 exosomes at a scale to meet early clinical demand. The company has plans to expand this initiative beyond stroke for preclinical studies in epilepsy, traumatic brain and spinal cord injuries later this year.
The Latest on: Stroke treatment
via Google News
The Latest on: Stroke treatment
- For Heart Patients, CPAP Treatment May Ease Depression: Studyon August 16, 2019 at 11:35 am
FRIDAY, Aug. 16, 2019 (HealthDay News) -- Continuous positive airway pressure (CPAP) treatment of obstructive sleep apnea can ease depression in people with heart disease, according to a ...
- Gabon's Bongo in first live public appearance after strokeon August 16, 2019 at 4:58 am
Speculation about Bongo's ability to rule the small oil-rich country surged after he suffered a stroke on October 24 while in Saudi Arabia. He was flown to Morocco for treatment, returning in January.
- Music as medicine studied in treatment of strokes, depression and Alzheimer'son August 15, 2019 at 9:30 pm
Well, what if music could do more than that? What if it could work as medicine for your brain? There would mean major implications for stroke victims, those battling depression and Alzheimer's ...
- Music as medicine studied in treatment of Alzheimer's, stroke and depressionon August 15, 2019 at 4:26 pm
Methodist Hospital’s Center for Performing Arts Medicine is conducting a new study on music as medicine. Lead researcher Dr. Mei Rui is also an internationally-known concert pianist. She will perform ...
- Stroke: causes, symptoms and treatmenton August 15, 2019 at 3:34 pm
A stroke can happen to anyone at any time, but certain factors such as smoking, suffering from diabetes or drinking too much alcohol will make you more at risk. Sadly, strokes are a very serious ...
- Disparities in access to best stroke treatmenton August 15, 2019 at 2:43 pm
(Reuters Health) - Less than 10% of U.S. stroke patients get a treatment that evidence shows is most effective for a certain type of stroke – and the odds are even lower for patients who are black and ...
- Aspirin, rivaroxaban similar for recurrent stroke prevention in certain patientson August 15, 2019 at 10:57 am
there was no significant treatment interaction between patients with and without carotid stenosis or plaque. Carotid plaque was much more often present ipsilateral to the qualifying ischemic stroke ...
- AHA News: Age Could Be Key to Women's Worse Quality of Life Post-Strokeon August 15, 2019 at 9:36 am
The differences had nothing to do with the stroke care they received, as both men and women received similar medical treatment. "Women's age is really what's driving this difference in terms of the ...
- Researchers building glove to treat symptoms of strokeon August 15, 2019 at 5:20 am
Reaching for new stroke treatments Seim, Lansberg and Okamura's goal is a tall order. Despite some individual success stories, the reality is that most stroke patients struggle to regain the ...
- Immediate antihypertensive treatment after stroke may benefit certain patientson August 10, 2019 at 5:05 am
Initiating antihypertensive therapy immediately after acute ischemic stroke reduced recurrent stroke risk in patients with prior hypertension but did not affect other outcomes, researchers reported.
via Bing News