Scientists create functioning kidney tissue
Kidney glomeruli – constituent microscopic parts of the organ- were generated from human embryonic stem cells grown in plastic laboratory culture dishes containing a nutrient broth known as culture medium, containing molecules to promote kidney development.
They were combined with a gel like substance, which acted as natural connective tissue – and then injected as a tiny clump under the skin of mice.
After three months, an examination of the tissue revealed that nephrons: the microscopic structural and functional units of the kidney – had formed.
The new structures contained most of the constituent parts present in human nephrons – including proximal tubules, distal tubules, Bowman’s capsule and Loop of Henle.
Tiny human blood vessels – known as capillaries- had developed inside the mice which nourished the new kidney structures.
However, the mini-kidneys lack a large artery, and without that the organ’s function will only be a fraction of normal.
So, the researchers are working with surgeons to put in an artery that will bring more blood the new kidney.
To test the functionality of the new structures, the team used Dextran – a fluorescent protein which stains the urine-like substance produced when nephrons filter the blood, called glomerular filtrate.
The Dextran was tracked and detected in the new structures’ tubules, demonstrating that filtrate was indeed being produced and excreted as urine.
“We have proved beyond any doubt these structures function as kidney cells by filtering blood and producing urine – though we can’t yet say what percentage of function exists,” said Professor Kimber.
“What is particularly exciting is that the structures are made of human cells which developed an excellent capillary blood supply, becoming linked to the vasculature of the mouse.
“Though this structure was formed from several hundred glomeruli, and humans have about a million in their kidneys – this is clearly a major advance.
“It constitutes a proof of principle- but much work is yet to be done.”
Learn more: Scientists create functioning kidney tissue
The Latest on: Kidney disease
via Google News
The Latest on: Kidney disease
- Texans' D.J. Reader supports kidney disease research at VIP hotel eventon November 19, 2019 at 2:18 pm
Texans' D.J. Reader ‘Captures the Moon!’ at the newly opened Cambria Hotel Houston Downtown Convention Center’s VIP paint night event. >>>See more photos from the Texans' game against Baltimore on ...
- Emergent Health Corp. (OTC PINK:EMGE) Announces New Evidence That Chronic Kidney Disease and Renal Dialysis Time May Be Reduced or Reversedon November 19, 2019 at 8:18 am
KING OF PRUSSIA, PA / ACCESSWIRE / November 19, 2019 / Chronic Kidney Disease (CKD) is a world-wide affliction. Many CKD patients find they can not survive without the life-saving procedure known as ...
- Robotic transplants safe for kidney disease patients with obesityon November 19, 2019 at 8:04 am
Researchers at the University of Illinois at Chicago report that among patients with obesity, robotic kidney transplants produce survival outcomes comparable to those seen among nonobese patients.
- Penn-Harris-Madison rallies around 11-year-old student fighting kidney diseaseon November 18, 2019 at 3:20 am
It’s a dialysis machine with soft tubes, needles, fluid bags and a dialyzer (also called an artificial kidney). Alex has Stage 5 Chronic Kidney Disease. Over the past year-and-a-half, Amber Deranek, ...
- Chronic Kidney Disease (CKD) Drugs Market 2019 Global Analysis & Forecast to 2023 Market Research Reporton November 18, 2019 at 2:53 am
With an increase in the incidence of chronic kidney conditions, report analysts believe that the global market for chronic kidney disease drugs will witness good growth over the forecast period.
- Genetic Characteristics of Korean Patients with Autosomal Dominant Polycystic Kidney Disease by Targeted Exome Sequencingon November 18, 2019 at 2:23 am
Autosomal dominant polycystic kidney disease (ADPKD) is a potentially lethal monogenic disorder characterized by numerous cysts in the kidneys and progressive renal failure 1. Since the disease is ...
- Chronic Kidney Disease Drugs Market Opportunities, Size, Share, Emerging Trends, Technological Innovation And Forecasts To 2025on November 17, 2019 at 10:42 pm
Nov 18, 2019 (AmericaNewsHour) -- Global Chronic Kidney Disease Drugs Market - Drivers, Restraints, Opportunities, Trends, and Forecast up to 2025 [85 pages report] This market research report ...
- How former Revs midfielder Clyde Simms moved on after kidney diseaseon November 17, 2019 at 1:40 pm
How former Revs midfielder Clyde Simms moved on after kidney disease originally appeared on NBC Sports Boston By the time Clyde Simms was forced to retire from the New England Revolution at age 31, ...
- ISCHEMIA-CKD Trial: Advanced Chronic Kidney Disease Patients Treated with Invasive Heart Procedures Show No Reduction in Rate of Cardiac Eventson November 16, 2019 at 10:15 am
BROOKLYN, N.Y., Nov. 16, 2019 /PRNewswire/ -- Heart disease is the leading cause of death for the roughly 500 million people worldwide with chronic kidney disease (CKD). Yet such patients have ...
via Bing News