Common blood pressure medicine blocks molecule that can trigger the disease
A drug commonly used to control high blood pressure may also help prevent the onset of Type 1 diabetes in up to 60 percent of those at risk for the disease, according to researchers at the University of Colorado Anschutz Medical Campus and the University of Florida (UF) in Gainesville.
The study was published online this week in the Journal of Clinical Investigation.
“This is the first personalized treatment for Type 1 diabetes prevention,” said Aaron Michels, MD, a researcher at the Barbara Davis Center for Childhood Diabetes and associate professor of medicine at CU Anschutz. “We made this discovery using a supercomputer, on the lab bench, in mice and in humans.”
The drug, methyldopa, has been used for over 50 years to treat high blood pressure in pregnant women and children. It is on the World Health Organization’s list of essential drugs.
But like many drugs used for one condition, Michels and his colleagues found it useful for something totally unrelated.
Some 60 percent of people at risk of getting Type 1 diabetes possess the DQ8 molecule which significantly increases the chance of getting the disease. The researchers believed that if they could block specifically the DQ8 molecule they could also block the onset of the disease.
“All drugs have off-target effects. If you take too much acetaminophen you can hurt your liver,” Michels said. “We took every FDA-approved small molecule drug and analyzed HLA-DQ8 binding through a supercomputer. We searched a thousand orientations for each drug to identify those that would fit within the DQ8 molecule binding groove.”
After running thousands of drugs through the supercomputer, they found that methyldopa not only blocked DQ8, but it didn’t harm the immune function of other cells like many immunosuppressant drugs do.
The research spanned 10 years and its efficacy was shown in mice and in 20 Type 1 diabetes patients who took part in a clinical trial at the Barbara Davis Center at the University of Colorado School of Medicine.
“We can now predict with almost 100 percent accuracy who is likely to get Type 1 diabetes,” Michels said. “The goal with this drug is to delay or prevent the onset of the disease among those at risk.”
The drug is taken orally, three times a day.
Implications for treatment
Michels and UF Health researcher David Ostrov, PhD, hope this same approach of blocking specific molecules can be used in other diseases.
“This study has significant implications for treatment of diabetes and also other autoimmune diseases,” said Ostrov, associate professor of pathology, immunology and laboratory medicine in the UF College of Medicine and a member of the UF Health Cancer Center, Genetics Institute and Center for NeuroGenetics. “This study suggests that the same approach may be adapted to prevent autoimmune diseases such as rheumatoid arthritis, coeliac disease, multiple sclerosis, systemic lupus erythematosus and others.”
The next step will be a larger clinical trial sponsored by the National Institutes of Health in spring.
“With this drug, we can potentially prevent up to 60 percent of Type 1 diabetes in those at risk for the disease,” Michels said. “This is very significant development.”
The Latest on: Type 1 diabetes
via Google News
The Latest on: Type 1 diabetes
- Teen raises awareness of type 1 diabeteson November 27, 2019 at 8:03 pm
I went to the hospital and my blood sugar was more than 500. It is normally between 80 and 150. I did not know what diabetes was. I am type 1. Your pancreas stops working and your body does not ...
- Link Found Between Gender Dysphoria and Type 1 Diabeteson November 27, 2019 at 7:50 am
Youth with gender dysphoria may be at increased risk for developing type 1 diabetes, new observational research suggests. The study of more than 2000 individuals aged 10 to 21 years at a single ...
- What Triggers Type 1 Diabetes?on November 25, 2019 at 3:02 am
When my type 1 diabetes (T1D) was diagnosed in 1962, scientists couldn’t explain the cause of the disease or what triggered it. Fifty-seven years later, I’m still waiting for researchers to tell me ...
- The 'Taboo' Type 1 Diabetes Medication: What to Know About SLGT2 Inhibitorson November 24, 2019 at 9:58 pm
Many of you have probably heard of an SGLT2-inhibitor, an oral medication FDA approved for use in type 2 diabetes. Although very effective in blood glucose (BG) control, the FDA has not yet approved ...
- The 'Taboo' Type 1 Diabetes Medication: What to Know About GLP-1 Therapyon November 24, 2019 at 4:12 pm
As most of us know, diabetes is a progressive disease that can be caused by insulin resistance, lack of insulin production, or both! Type 1 diabetes is typically autoimmune and characterized by a ...
- Cannabis tied to serious complications in type 1 diabeteson November 22, 2019 at 2:49 pm
(Reuters Health) - People with type 1 diabetes may be more than twice as likely to develop potentially fatal complications when they use cannabis somewhat regularly than when they avoid the drug or ...
- What Causes Type 1 Diabetes? 3 Things You Need to Know, According to Doctorson November 22, 2019 at 9:06 am
You likely already know the deal about causes of type 2 diabetes—things like genetics and lifestyle huge factors. But when it comes to type 1 diabetes, the reasons for developing it aren't so ...
- Fiona Wylde: How This World Champion Athlete Overcomes Type 1 Diabeteson November 19, 2019 at 5:14 pm
And, oh, by the way, she has Type 1 diabetes. Yes, Wylde has reached the pinnacle of a sport that includes doing this: Fiona Wylde tackles the waves while warming up for this year's Red Bull Heavy ...
- Type 1.5 diabetes: Restaurateur's own diagnosis of rare disease inspires new menuon November 19, 2019 at 10:46 am
Doctors told him he’s in a rare category called Type 1.5 – sometimes referred to as Latant Auto-Immune Diabetes in Adults. "They look and are a Type 1, but they are not in the typical age group,” said ...
via Bing News