A new 3D printing technique allows researchers to replicate biological structures, which could be used for tissue regeneration and replica organs.
Imperial College London researchers have developed a new method for creating 3D structures using cryogenics (freezing) and 3D printing techniques.
This builds on previous research but is the first to create structures that are soft enough to mimic the mechanical properties of organs such as the brain and lungs. Their technique, created in collaboration with Kings College London, is published in the journal Scientific Reports.
At the moment we have created structures a few centimetres in size, but ideally we’d like to create a replica of a whole organ using this technique.
– Zhengchu Tan
Being able to match the structure and softness of body tissues means that these structures could be used in medical procedures to form scaffolds that can act as a template for tissue regeneration, where damaged tissues are encouraged to regrow.
Regenerating damaged tissue by ‘seeding’ porous scaffolds with cells and encouraging them to grow allows the body to heal without the issues that normally affect tissue-replacing transplant procedures, such as rejection by the body.
The use of scaffolds is becoming more common and varied in its applications, but this new technique is special in that it creates super-soft scaffolds that are like the softest tissues in the human body and could help to promote this regeneration. In particular, there might be future potential in seeding neuronal cells; those involved in the brain and spinal cord.
The researchers tested the 3D-printed structures by seeding them with dermal fibroblast cells, which generate connective tissue in the skin, and found that there was successful attachment and survival.
This success, alongside previous research, could lead to further possibilities around the growth of stem cells, which is medically exciting due to their ability to change into different types of cells.
Additionally, the technique could be used to create replica body parts or even whole organs. These could be incredibly useful to scientists, allowing them to carry out experiments not possible on live subjects. They could even be used to help with medical training, replacing the need for animal bodies to practice surgery on.
Zhengchu Tan, one of the researchers from the Department of Mechanical Engineering at Imperial, said: “At the moment we have created structures a few centimetres in size, but ideally we’d like to create a replica of a whole organ using this technique.”
The technique uses solid carbon dioxide (dry ice) to rapidly cool a hydrogel ink as it is extruded from a 3D printer. After being thawed, the gel formed is as soft as body tissues, but doesn’t collapse under its own weight, which has been a problem for similar techniques in the past.
Dr Antonio Elia Forte, one of the researchers from the Department of Bioengineering at Imperial, said: “Cryogenics is the novel aspect of this technology – it uses the phase change between liquid and solid to trigger polymerisation and create super soft objects that can hold their shape. This means that the technology has a wide variety of possible uses.”
The Latest on: Tissue regeneration and replica organs
via Google News
The Latest on: Tissue regeneration and replica organs
- Vision Revisionon December 2, 2020 at 8:21 am
Harvard Medical School scientists have successfully restored vision in mice by turning back the clock on aged eye cells in the retina to recapture youthful gene function. The team’s work, described ...
- ‘Milestone’ Anti-Aging Treatment Restores Sight in Miceon December 2, 2020 at 7:57 am
Scientists said Wednesday they have restored sight in mice using a “milestone” treatment that returns cells to a more youthful state and could one day help treat glaucoma and other ...
- Discovery illuminates how cell growth pathway responds to signalson November 20, 2020 at 12:08 pm
A basic science discovery reveals a fundamental way cells interpret signals from their environment and may eventually pave the way for potential new therapies.
- Tissue Regeneration Market 2020 Showing Tremendous…on November 11, 2020 at 10:46 am
Increasing medical applications of 3D printing in tissue and organ regeneration may act as a market driver. Growing research and developments, innovations and funding in biomaterials, cell therapies, ...
- Scientists 3D bioprint hybrid tissue construct for cartilage regenerationon November 9, 2020 at 7:05 am
(Nanowerk News) Wake Forest Institute for Regenerative Medicine scientists (WFIRM) have developed a method to bioprint a type of cartilage that could someday help restore knee function damaged by ...
- Scientists create hybrid tissue construct for cartilage regenerationon November 9, 2020 at 12:52 am
Degeneration of the meniscus tissue ... new tissues and organs. "In this study, we have been able to produce a highly elastic hybrid construct for advanced fibrocartilaginous regeneration ...
- Tissue Regeneration and Organ Repair: Science or Science Fiction?on November 7, 2020 at 4:00 pm
The demand for tissue and organ replacement following tissue damage (eg, severe burns) or diseases (eg, cardiomyopathy) is expanding, and, while the number of patients suffering from organ failure ...
- Tissue Regeneration and Organ Repair: Science or Science Fiction?on October 13, 2020 at 4:59 pm
One area in which tissue engineering is already being applied ... For this reason, the choice of the structure on which bone regeneration is carried out is essential; it should be highly ...
- Understanding Mature Tissue or Organ Stem Cells and Their Clinical Applicationon September 13, 2020 at 9:40 pm
This work is providing the basis for ongoing preclinical and clinical trials of organ and tissue regeneration from healthy adult stem cells. By identifying adult stem cells from other tissues such as ...
via Bing News