The trials by researchers at RMIT University have uncovered mechanisms in the human body that have never been seen before, including a potentially new immune system.
The new technology and discoveries offer a game-changer for the one-in-five people worldwide who will suffer from a gastrointestinal disorder in their lifetime. They could also lead to fewer invasive procedures like colonoscopies.
The ingestible capsule (the size of a vitamin pill) detects and measures gut gases – hydrogen, carbon dioxides and oxygen – in real time. This data can be sent to a mobile phone.
Professor Kourosh Kalantar-zadeh, study lead and capsule co-inventor, said the trials showed that the human stomach uses an oxidiser to fight foreign bodies in the gut.
“We found that the stomach releases oxidising chemicals to break down and beat foreign compounds that are staying in the stomach for longer than usual,” Kalantar-zadeh said.
“This could represent a gastric protection system against foreign bodies. Such an immune mechanism has never been reported before.”
Another never before seen observation from the trial was that the colon may contain oxygen.
“Trials showed the presence of high concentrations of oxygen in the colon under an extremely high-fibre diet,” Kalantar-zadeh said. “This contradicts the old belief that the colon is always oxygen free.
“This new information could help us better understand how debilitating diseases like colon cancer occur.”
The trials were conducted on seven healthy individuals on low- and high-fibre diets. Results showed that the capsule accurately shows the onset of food fermentation, highlighting their potential to clinically monitor digestion and normal gut health.
The trials also demonstrated that the capsule could offer a much more effective way of measuring microbiome activities in the stomach, a critical way of determining gut health.
“Previously, we have had to rely on faecal samples or surgery to sample and analyse microbes in the gut,” Kalantar-zadeh said.
“But this meant measuring them when they are not a true reflection of the gut microbiota at that time. Our capsule will offer a non-invasive method to measure microbiome activity.”
This could represent a gastric protection system against foreign bodies. Such an immune mechanism has never been reported before.
Now that the capsule has successfully passed human trials, the research team is seeking to commercialise the technology.
Co-inventor Dr Kyle Berean said: “The trials show that the capsules are perfectly safe, with no retention.
“Our ingestible sensors offer a potential diagnostic tool for many disorders of the gut from food nutrient malabsorption to colon cancer. It is good news that a less invasive procedure will now be an option for so many people in the future.
“We have partnered with Planet Innovation to establish a company called Atmo Biosciences and bring the product to market.
“This will lead to Phase II human trials, and help raise the funds needed place this safe and revolutionary gut monitoring and diagnostic device into the hands of patients and medical professionals.”
The Latest on: Swallowable sensors
- Measuring UV-C For About $5on June 20, 2020 at 5:00 pm
It is built around a $2.50 sensor and a $3 Arduino. The NukeMeter is built around a GUVA-S12SD UV sensor breakout board. This sensor is really designed for UV-A detection, but a quick look at the ...
- Pill with a Viewon June 17, 2020 at 5:00 pm
By comparison, conventional CMOS sensors dissipate between 50 and 100 mW of power." According to Given Imaging, once the patient has swallowed the M2A Swallowable Imaging Capsule, it passes smoothly ...
- Sensor Advances Spur New Diagnostic, Therapeutic Toolson June 17, 2020 at 5:00 pm
Ball Semiconductors' spherical chip could produce 3-D sensing capabilities. Applications include sensor-tipped catheters, implant markers, and swallowable vital signs sensors. Photo courtesy of Ball ...
- Hemas Hospital introduces capsule endoscopyon June 16, 2020 at 5:00 pm
As the name implies, capsule endoscopy makes use of a swallowable capsule which contains a micro video ... When performing this test a jacket with sensor devices is worn over the abdomen by the ...
- Wi-Fi Is a Power Guzzler. New Multi-Protocol Modules May Change the Game of Battery-Based IoTon June 9, 2020 at 11:06 am
Years ago, Xu's wife, a medical professional, was working with small swallowable pills that acted as cameras down the patient's digestive tract, sending information to doctors wirelessly. To work ...
- 6 apps to help lower your health-care costson May 18, 2020 at 8:47 am
A 2012 Pew Internet & American Life poll found 37 percent of Americans accessed apps to track their well-being ... A confluence of medicine, nanotechnology, sensor science, social networks ...
- Scientists develop swallowable, self-inflating capsule to facilitate weight losson April 28, 2019 at 9:27 pm
Its location in the stomach is ascertained by a magnetic sensor. An external magnet measuring 5cm in diameter is used to attract the magnet attached to the inflation valve, opening the valve.
- Radio Telemetry Transmitterson February 20, 2018 at 2:38 am
Description: RT400 SERIES - AN INNOVATIVE SOLUTION OMEGA's remote telemetry system for mV sensors provides an innovative alternative to costly cables or wires in difficult installations. The RT400 ...
- Are Schools Overregulating What Students Eat?on June 1, 2015 at 3:30 am
One blogger wondered whether so-called helicopter parents in 2024 would give their kids swallowable sensors that would tell a smartphone if the kids were eating too much sugar, fat or gluten.
- Israel's lively start-up culture keeps economy thrivingon November 9, 2009 at 4:00 am
He adapted the sensor to produce a swallowable camera, the size of a pill, to beam out a movie from inside a patient's intestines. This is making some highly invasive and painful diagnostic ...
via Google News and Bing News