A blood test using infrared spectroscopy can be used to diagnose two types of cancer, lymphoma and melanoma, according to a study led by Georgia State University.
Researchers used mid-infrared spectroscopy to analyze blood serum derived from experimental mice and differentiate mice with non-Hodgkin’s lymphoma and subcutaneous melanoma from healthy mice and also between these two tumorous conditions. The mid-infrared spectral region of the electromagnetic spectrum is frequently used to characterize biological samples at the molecular level.
The findings, published in the journal Scientific Reports, suggest infrared spectroscopy can detect biochemical changes induced by non-Hodgkin’s lymphoma, a solid tumorous condition of the immune system, and subcutaneous melanoma, a deadly form of skin cancer, and has diagnostic potential as a screening technique for these cancers.
Studies have found the incidence rates of cutaneous melanoma have increased in many regions and populations over the last decade, specifically 3 to 7 percent per year among fair-skinned populations. Also, non-Hodgkin’s lymphoma accounts for 4.3 percent of new cancer cases in the United States. The available diagnostic regimen for both cancers, which includes tissue examination and biopsy, is time-consuming, invasive and costly, resulting in small compliance rates of eligible populations for cancer prescreening.
Developing a rapid and reliable prescreening strategy for melanoma and lymphoma is critical because early diagnosis and treatment of these malignancies improve the patients’ chances of survival. Fourier Transform Infrared (FTIR) spectroscopy in Attenuated Total Reflection (ATR) sampling mode provides high-quality results with better reproducibility compared to other vibrational spectroscopy. It has attracted scientists’ attention for its rapid and reliable detection of various health conditions using body fluid samples.
In previous work, Dr. Unil Perera, Regents’ Professor of Physics at Georgia State, and his colleagues discovered that a fast, simple blood test for ulcerative colitis using ATR-FTIR spectroscopy could provide a cheaper, less invasive alternative for screening compared to colonoscopy.
“Our final goal is to say we can use this infrared technique to identify various diseases,” Perera said. “This study shows infrared spectroscopy can identify cancer. Right now, when you go to the doctor, they do blood tests for sugar and several other things, but not for serious diseases like cancer and colitis. If you are a healthy person, there is a range that is normal. One day, we hope that even these serious diseases can be rapidly screened. Your primary doctor could keep a record of your number and check that every time you come back. Then, if there is some indication of cancer or colitis, they can do biopsies, colonoscopies, etc.”
In this recent study, the researchers used mice with lymphoma and melanoma cancers. Blood serum droplets extracted from cancerous mice and control mice were placed on an ATR crystal of the FTIR instrument. Incident infrared beams were absorbed and reflected by the serum, creating a wave that was recorded and used to produce an absorbance curve with peaks that identified the presence of certain biomarkers in the sample.
The researchers compared the absorbance curves from the control and tumorous mice and assessed biochemical changes induced by non-Hodgkin’s lymphoma and subcutaneous melanoma in the serum samples obtained from Dr. Yuan Liu’s research lab in Georgia State’s Department of Biology.
The study found remarkable differences between the ATR-FTIR spectra of serum samples from tumor-bearing mice with melanoma and non-Hodgkin’s lymphoma and healthy, control mice.
The findings are applicable to humans because mice and humans have some biomarkers and chemicals in common, Perera said. In previous studies on colitis, Perera and his colleagues identified specific chemicals that changed in humans and mice when colitis was present.
Using the data collected on the biomarkers for lymphoma and melanoma, the researchers can develop detectors for these particular absorbance peaks, which doctors could use to test patients’ blood samples for these cancers.
Doctors could track a patient’s blood test numbers starting in infancy and monitor them over the years to know exactly when the numbers begin to change. To make before and after comparisons of the blood samples, the data could be entered into a computer program and available statistical analysis software would determine any significant differences. Doctors wouldn’t need to do any sophisticated analysis, Perera said.
This work could lay the foundation for further research that could lead to the development of diagnostic techniques for the health care of melanoma and lymphoma cancer patients using body fluid samples that can be collected with relatively low risks, Perera said. In the future, Perera and his colleagues would like to use samples from human patients for infrared spectroscopy studies of cancer and other diseases.
The Latest on: Diagnosing diseases with infrared spectroscopy
- Researchers enlist the cloud to wipe out malariaon October 16, 2019 at 7:09 am
Some of these people could appear to be healthy, but they harbored the parasite and acted as reservoirs for the spread of disease. "We have invented a portable, rugged measurement system based on ...
- Spectroscopic blood test tipped for brain tumor triageon October 15, 2019 at 6:57 am
A simple blood test based on infrared spectroscopy could help speed up the diagnosis of brain tumors, say researchers developing the technology ... which might be the result of a brain tumor but are ...
- AI Detects Brain Cancer from a Blood Teston October 14, 2019 at 4:51 pm
Liquid biopsy is a non-invasive way of detecting diseases ... spectroscopy on blood samples to reveal biochemical signatures. Spectroscopy is the science of splitting light (electromagnetic radiation) ...
- Blood Test to Diagnose Brain Cancer in Developmenton October 11, 2019 at 5:25 am
A new blood test that uses attenuated total reflection (ATR)-Fourier transform infrared (FTIR) spectroscopy in conjunction with machine learning ... to find new treatments and ultimately a cure as ...
- Development of high-throughput ATR-FTIR technology for rapid triage of brain canceron October 8, 2019 at 8:07 am
A simple test for the early diagnosis of brain cancer ... has implications in the field of IR spectroscopy as well as the clinical environment. Analysis of blood serum using this technique would fit ...
- ATR-FTIR in the Food and Beverage Industryon October 8, 2019 at 6:43 am
Attenuated total reflection (ATR) is an analytical method that is typically used in combination with traditional IR spectroscopy, allowing specimens to be examined in ... focussing on Microbiology and ...
- Study Shows Safety and Efficacy of Near Infrared Spectroscopy (NIRS) Imaging to Identify Patients and Plaques at an Increased Risk for MACEon September 27, 2019 at 12:19 pm
The landmark study demonstrated that near-infrared spectroscopy (NIRS ... is advancing the diagnosis and management of coronary artery disease by providing cardiologists with the most precise imaging ...
- Measuring Pain Levels Using Functional Near Infrared Spectroscopyon September 18, 2019 at 8:06 am
Knowing how much pain a patient is in can help clinicians to diagnose a condition ... They’re using functional near infrared spectroscopy to peer into the prefrontal cortex of the brain and assess the ...
- Critical improvements to functional Near Infrared Spectroscopy enhance brain imagingon August 22, 2019 at 1:33 am
"High density functional diffuse optical tomography based on frequency domain measurements improves image quality and spatial resolution," researchers demonstrate critical improvements to functional ...
- Infrared Light May Be a New Way To Help Diagnose Rheumatoid Arthritison July 15, 2019 at 10:52 am
There’s no cure for RA, so this tool could potentially lead to earlier diagnosis and disease management ... uses three-dimensional digital imaging with infrared spectroscopy to create a ...
via Google News and Bing News