A new drug being trialled for treating breast cancer and diabetes has been shown to ‘melt away’ the fat inside arteries that can cause heart attacks and strokes.
Researchers from the University of Aberdeen, using pre-clinical mouse models, showed that just a single dose of the drug (Trodusquemine) completely reversed the effects of a disease that causes a host of heart problems.
Atherosclerosis is the build-up of fatty material inside the arteries.
Over time this fatty material can grow bigger until your arteries become so narrow that not enough blood can pass through.
Atherosclerosis is the condition that causes most heart attacks and strokes.
In pre-clinical tests, mice with set-in atherosclerosis, mimicking what happens in humans, had less fatty plaques in their arteries whether they had regular doses over time or just a single dose of Trodusquemine.
The drug works by stopping an enzyme called PTP1B, which is normally increased in people with obesity or diabetes and conditions involving prolonged inflammation such as sepsis, inflamed diabetic foot ulcers and allergic lung inflammation. The researchers found that it also stimulated the action of another protein (AMPK), which effectively mimics exercise and reduces chronic inflammation.
It has already been shown to be effective with diabetes and breast cancer patients but this is the first time the drug has been shown to have benefits for long-term cardiovascular disease.
The £236,000 study was funded by the British Heart Foundation.
Professor Mirela Delibegovic and Dr Dawn Thompson from the University of Aberdeen’s Institute of Medical Sciences who led the study said: “All humans have some level of atherosclerosis. As you age you start to develop these fatty streaks inside your arteries. It is a big problem for people who are overweight or have underlying cardiovascular conditions.”
“Trodusquemine has already been trialled for treatment of diabetes and breast cancer but this is the first time it has been used in models of atherosclerosis.
“These have only been tested at pre-clinical level, in mice, so far but the results were quite impressive and showed that just a single dose of this drug seemed to completely reverse the effects of arthrosclerosis.
“The next step is to test the ability of this drug to improve outcomes in human patients with developed atherosclerosis and cardiovascular disease”.
Learn more: Drug ‘melts away’ fat inside arteries
The Latest on: Atherosclerosis
No news articles
- Examining a Possible Link Between Atherosclerosis and Inflammationon November 19, 2020 at 2:36 pm
Unfortunately, this inflammation can damage the site even further, which occurs quite often in cardiovascular disease. Atherosclerosis is a cardiovascular disease that occurs when fats build up and ...
- Jose Ordovás, PhD, on Body Size and Its Effect on Subclinical Atherosclerosis Prevalenceon November 19, 2020 at 7:59 am
Body size affects the prevalence of subclinical atherosclerosis (SA), suggesting medication and other lifestyle changes could improve cardiac risk in those who fall into a riskier body-size category, ...
- Association between periodontal disease and atherosclerosis in patients with rheumatoid arthritison November 18, 2020 at 6:23 pm
Among 197 patients with rheumatoid arthritis, those with antibody responses to common periodontal pathogens were more likely to also show signs of atherosclerosis. Evidence of exposure to a particular ...
- Antibody therapy halves ‘bad’ cholesterol levelson November 18, 2020 at 10:07 am
Cardiologists in the U.S. recommend that individuals who are at very high risk of cardiovascular disease due atherosclerosis aim for an LDL cholesterol level of around 70 mg/dl of blood.
- Atherosclerosis: Symptoms, Causes, Treatment And Tips To Prevent by Dr Viveka Kumaron November 17, 2020 at 6:09 am
Atherosclerosis is a health problem that bothers many people. Know the causes, symptoms, treatment and tips to prevent from a cardiologist. Atherosclerosis is a very broad term which means that ...
- Analysis of genes and underlying mechanisms involved in foam cells formation and atherosclerosis developmenton November 16, 2020 at 3:59 pm
(D) Venn diagram showing the overlap of DEGs in the ox-LDL-treated SMCs (with downregulated and upregulated trends overtime obtained by STEM analysis) and atherosclerosis-related genes, which were ...
- Tomocube’s HT-2 microscope quantifies therapeutic effects of targeted nanodrugs against atherosclerosison November 16, 2020 at 10:59 am
Treatment of Atherosclerosis, the disease responsible for approximately half of all deaths in westernized societies, is a step closer following correlative studies using Tomocube’s HT-2 microscope.
- 15 Foods That May Help Prevent Clogged Arterieson November 15, 2020 at 4:00 pm
Atherosclerosis occurs when fatty deposits accumulate along artery walls. You may have heard the condition referred to as clogged arteries or a hardening of the arteries. This causes the arteries ...
- New screening questionnaire can identify people at high risk of developing heart diseaseon November 14, 2020 at 8:57 am
A new study in a Swedish population of middle-aged adults found that four out of 10 people have atherosclerosis, a buildup of fatty deposits that reduce blood flow to the heart. Early detection of ...
- SCAPIS: Simple Questionnaire Can Identify Silent Atherosclerosison November 12, 2020 at 4:00 pm
Individuals in the general population with high levels of silent coronary atherosclerosis can be successfully identified with a simple questionnaire that they can complete themselves at home ...
via Google News and Bing News