Instant coffee and powdered milk are produced by spray drying. Fraunhofer researchers have adapted this technique to the tricky question of incorporating insoluble substances in core-shell particles. The new method helps reduce the concentration of active ingredients in therapeutic medications.
Encapsulation is used in cosmetics and pharmaceuticals to protect active ingredients against external influences such as aggressive gastric acid. Another use of encapsulation is to control the release of active ingredients inside the body: depending on the permeability of the shell material, the medication is delivered gradually rather than all at once. Because such systems release multiple, smaller doses over an extended period of time, the drug therapy is better tolerated and easier to administer. In some cases, it means taking just one pill a day instead of three.
Insoluble substances are a problem
The first step of the encapsulation process involves dissolving the active ingredient in a liquid medium and mixing it with the shell material. Then the solution is piped to an orifice in the center of a nozzle surrounded by an annular channel through which compressed air is injected at high speed. The pressure disperses the solution into an aerosol of fine droplets, which is then sprayed into a drying cylinder. Here, the liquid evaporates, leaving behind a fine powder of core-shell particles. The problem is that it is difficult to mix insoluble substances with other materials. This limits the choice of shell materials that can be used to produce the particles.
Three-way nozzle permits endless combinations of materials
“For this reason, we use a three-way nozzle to implement spraying. Its advantage is that it permits two substances to be fed separately to the nozzle. The shear forces mix the substances together at the orifice of the nozzle, creating an aerosol containing both materials,” explains Michael Walz, who developed and optimized the new technique with his colleague Dr. Achim Weber at the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart.
This system permits endless combinations of materials, enabling the controlled release of active ingredients to be adapted to different applications. “We can modify the particle size and encapsulation efficiency by selecting the appropriate substances and by varying the concentration of the solution, the liquid volume flow, the drying temperature, and the pressure applied to the nozzle. This gives us the capability to respond to almost any customer requirement and develop solutions tailored to their needs,” says Weber.
The new process for the encapsulation of active ingredients could be of interest to fertilizer manufacturers and food processing companies as well as the cosmetics and pharmaceutical industries.
The Latest on: Drug delivery
Nasal Drug Delivery Market Analysis Revealing Key Drivers, Growth Trends and Competitive Assessment through 2022
on April 18, 2019 at 12:15 am
“Nasal Drug Delivery Market” Report of Market Research Future (MRFR)’s Explores Scope of the Study as Research Objective, Assumptions and Limitations in-depth. The report gives Market Dynamics by ... […]
Shape-Shifting Biomaterials Form the Basis of New Drug Delivery Platforms (1 of 1) (image)
on April 17, 2019 at 1:12 pm
An x-ray image showing the flower-like device deployed in the esophagus in pigs, where it could deliver molecules through degradable microneedles. This material relates to a paper that appeared in the ... […]
Temperature-Triggerable Gastrointestinal (GI) Drug Delivery Devices (image)
on April 17, 2019 at 11:20 am
Investigators tested two prototype devices in a porcine model: 1) a temperature-triggerable flower-like system for esophageal drug delivery and 2) a temperature-triggerable flexible mechanical ... […]
Drug Delivery in Cancer Market 2019 Global Trends, Market Share, Industry Size, Growth, Opportunities and Forecast to 2024
on April 17, 2019 at 4:00 am
WiseGuyReports.com adds “Drug Delivery in Cancer Market 2019 Global Analysis, Growth, Trends and Opportunities Research Report Forecasting to 2024” reports to its database. This ... […]
Global Drug Delivery in Cancer Industry Analysis 2019, Market Growth, Trends, Opportunities Forecast To 2024
on April 17, 2019 at 3:56 am
WiseGuyReports.com adds “Drug Delivery in Cancer Market 2019 Global Analysis, Growth, Trends and Opportunities Research Report Forecasting to 2024” reports to its database. This report focuses on the ... […]
New drug-delivery system senses high oxidant levels, responds to body chemistry and environment
on April 16, 2019 at 10:32 pm
Oxidants found within living organisms are byproducts of metabolism and are essential to wound-healing and immunity. However, when their concentrations become too high, inflammation and tissue damage ... […]
eBrain: a Three Dimensional Simulation Tool to Study Drug Delivery in the Brain
on April 16, 2019 at 2:17 am
Neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease are severe disorders with acute symptoms that gradually progress. In the course of developing disease-modifying treatments for ... […]
2 charged with drug delivery resulting in death
on April 12, 2019 at 9:38 am
Miller and Mullins were arrested Thursday on felony counts of drug delivery resulting in death, possession with intent to deliver, conspiracy to commit drug delivery resulting in death, and criminal ... […]
Two facing drug delivery resulting in death charges
on April 12, 2019 at 7:03 am
YORK COUNTY, Pa.– UPDATE (April 12): Katherine Miller is now facing charges in connection to Grubb’s death. Miller, 32, is facing criminal conspiracy, drug delivery resulting and death, and ... […]
New method may lead to better in vivo drug delivery
on April 12, 2019 at 4:00 am
At some point, every person is likely to experience an inflammatory condition. There are many causes of inflammation, and just as many treatments. Some types of inflammation disappear by ... […]
via Google News and Bing News