In the largest and most conclusive study of its kind, researchers have analysed blood samples to create a novel and non-invasive way of helping to diagnose Alzheimer’s disease and distinguish between different types of neurodegenerative disorders.
Following this breakthrough discovery, Alzheimer’s sufferers may now have an additional test to improve the accuracy of diagnosis in order to better tailor appropriate treatment.
The research also offers a valuable opportunity to monitor the progression of the disease.
The international study in the Proceedings of the National Academy of Sciences USA used sensor-based technology with a diamond core to analyse approximately 550 blood samples.
By passing light through the diamond and observing its interactions with the blood plasma, researchers were able to identify specific chemical bonds within the blood. This biochemical data was used to compare blood samples from cases of Alzheimer’s disease and other neurodegenerative diseases with those from healthy controls.
The ground-breaking scientific investigation was carried out by researchers at Lancaster University, the University of Central Lancashire (UCLan), the University of Manchester and the Federal University of Rio Grande do Norte, Brazil.
Professor David Allsop from Lancaster University has been collaborating for many years withProfessor David Mann from the University of Manchester in searching for diagnostic markers for neurodegenerative disease in blood plasma.
They provided all of the plasma samples for the study, along with supporting clinical and genetic information, and expertise in Alzheimer’s and other neurodegenerative conditions.
Professor Allsop said: “A particularly exciting aspect of the study was the ability to distinguish accurately between Alzheimer’s disease and Lewy body dementia, which are conditions that both result in dementia and can be difficult to separate from each other based on clinical information and symptoms. By reduction of misdiagnosed cases and administration of appropriate treatment, many people could benefit from this type of blood test in the future.”
Alzheimer’s diagnosis currently involves careful medical evaluation including clinical history, memory testing and brain scans, yet the only conclusive diagnosis is determined by post-mortem examination. This new blood test offers a non-invasive, more accurate and relatively cost-effective method of diagnosis, which will ensure the correct management of the condition.
Professor Francis Martin, principal investigator of the study and Biosciences theme lead at UCLan, said: “We have an aging population, meaning that the incidence and prevalence of Alzheimer’s is increasing, as is the need for accurate diagnosis. The ability to identify different neurodegenerative diseases through the analysis of blood offers a faster and accurate way of establishing the most effective treatment plan as well as disease monitoring.”
This new approach could also offer potential for carrying out tests to identify and monitor early signs of mild cognitive impairment, meaning that the onset of Alzheimer’s and other types of neurodegenerative diseases could be detected early and intervention measures could be put in place earlier to slow the progress of these diseases.
Professor Martin added: “For those suffering with Alzheimer’s disease, the damage is already well advanced once conventionally diagnosed, but this new method offers a potentially effective early screening tool when patients are only demonstrating signs of mild cognitive impairment. This is a potentially significant breakthrough for the prevention of different debilitating and chronic neurological diseases.”
The Latest on: Alzheimer’s
- Alzheimer's cafe in Lincoln meets need for fellowshipon March 22, 2020 at 5:07 pm
LINCOLN, Neb. (AP) — The idea was so simple, Michele Carlson says. A safe space for people with Alzheimer’s and their caregivers. A place to go to have coffee and cookies. Put together a puzzle, sing, ...
- Alzheimers Q&A: How can Amazon's Alexa or Google's Assistant help those with Alzheimer's or dementia?on March 22, 2020 at 1:00 pm
There are many innovations and assistive technologies available now that can ease caregiver responsibilities and promote greater independence and a quality of life for the person affected by Alzheimer ...
- Alabama man serenades wife with Alzheimer's through window amid coronavirus nursing home restrictionson March 22, 2020 at 8:36 am
John Kline, 80, said he serenades his wife of 45 years because she has Alzheimer's, and he doesn't want her to forget him during their forced separation. A video of the couple singing together was ...
- Dover Police Find Missing Man With Alzheimer’son March 22, 2020 at 8:25 am
As a precaution, he is being transported to a hospital to be checked over. Police in Dover, Massachusetts searched for the 64-year-old man suffering from Alzheimer’s disease. Oglevee was last seen ...
- UPDATED: Police have found the missing Dover man with Alzheimer's.on March 22, 2020 at 8:16 am
Dover Police announced that the "best possible" outcome has occurred after the spent a day searching for a 64-year-old man with Alzheimer's disease. Police announced that they have found Scott Oglevee ...
- Dover Police searching for a missing man with Alzheimer's. He was last seen in Dedham.on March 22, 2020 at 7:42 am
Dover Police and State Police searching for a 64-year-old man with Alzheimer's disease. Police have issued a Silver Alter for Scott Oglevee who left his house about 11 a.m. Saturday. He is described ...
- Former Abilene Cooper baseball coach Andy Malone, 79, dies after battle with Alzheimer'son March 21, 2020 at 1:44 pm
Former Cooper baseball coach Andy Malone, who led the Cougars to titles in 1987 and 1988, died Friday evening in Marshall. He was 79 – just 17 days shy of his 80th birthday. Malone, known for his ...
- Startups offer promise for Alzheimer’s cureon March 21, 2020 at 10:49 am
Out-of-the-box research is bringing better treatment — and someday a cure — for Alzheimer’s disease, researchers said recently at a Palm Beach symposium at The Beach Club. “We fund early-stage ...
- Minnesota public health leader aims to bring equity to Alzheimer's careon March 20, 2020 at 3:37 pm
Cindy Kaigama knows firsthand the challenges of caring for a loved one with Alzheimer's disease. Cindy Kaigama, the health systems director for the Alzheimer's Association of Minnesota and Dakotas, ...
- Alzheimer's Disease Drug Trial Concludes Early Due to COVID-19 Concernson March 20, 2020 at 3:29 pm
For Axsome Therapeutics (NASDAQ:AXSM), adapting to COVID-19 has meant concluding patient participation early in the late-stage study of its lead drug candidate, AXS-05, in patients with Alzheimer's ...
via Google News and Bing News