Research conducted at Leiden has established that guts-on-chips respond in the same way to aspirin as real human organs do. This is a sign that these model organs are good predictors of the effect of medical drugs on the human body. Publication in Nature Communications on 15 August.
A method to test medical drugs for efficacy and potential side-effects, but then much cheaper and using the fewest possible lab animals: this is likely to be possible in future thanks to organs-on-chips, miniature model organs on microchips. In these model organs, which are equipped with human organ cells and microfluidic channels, researchers and pharmacists can mimic the working of an organ.
Leiden researchers, their spin-off company Mimetas and pharmaceutical company Roche have now shown that one type of organ chip experiences the same side-effects from the drug aspirin as the same organ in the human body. This is good news, because it is a sign that these miniature model organs are good predictors of the effect of medical drugs in the human body.
The researchers exposed 357 guts-on-chips for a significant period to the substance acetylsalicylic acid, better known as the analgesic aspirin. It has been known for a long time already that this substance can lead to gastrointestinal perforation, a complication that can be fatal if untreated. ‘We saw exactly the same side-effects occur in our guts-on-chips,’ says Professor of Analytical Biosciences Thomas Hankemeier. ‘In our model guts the gut wall also became more permeable after the drug had been administered.’
Effectiveness of candidate drugs
According to Hankemeier, the research shows that organs-on-chips are suited to testing a medical drug for efficacy and side-effects. This is good news for pharmacists, because the model organs make it easier for them to evaluate whether candidate drugs are effective or harmful. Many substances would be excluded from futher research before a drug entered the lab animal phase. This would help reduce the cost of drug production and mean less animal testing.
Organs-on-chips have taken off in recent years. They will be increasingly important in the near future, not just in drug development but also in the diagnosis of disease. Leiden researchers are at the forefront of this development. Hankemeier and a number of other groups (Erasmus MC, VUmc, RU Groningen) have been awared a 1.5 million ZonMW grant to research the effect of the body’s micro-organisms in the gut on the development of dementia. Organ-on-a-chip technology will play an important role here. Mimetas is the first company in the world to produce and sell organ chips on a large scale.
Learn more: Gut-on-chip good predictor of drug side-effects
The Latest on: Organs-on-chips
- University of Cincinnation November 17, 2020 at 4:00 pm
Riccardo Barrile, assistant professor of biomedical engineering at the University of Cincinnati College of Engineering and Applied Science, is combining three powerful technologies — stem cells, 3D ...
- 3-D printed stents that treat inflammationon November 10, 2020 at 7:53 am
Inc. which specializes in commercializing 3-D organs-on-chips and medical devices.
- 3D printed stents that treat inflammationon November 10, 2020 at 6:50 am
Inc. which specializes in commercializing 3D organs-on-chips and medical devices. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert!
- Biodegradable 3D-printed esophageal stents for treating radiation esophagitison November 9, 2020 at 4:00 pm
Inc. which specializes in commercializing 3D organs-on-chips and medical devices.
- This is Engineering Day: Interview with Professor Hazel Screenon November 3, 2020 at 12:42 pm
The idea is that you can use these miniaturised living systems, or Organs-on-Chips, to understand healthy and diseased tissues, and even test new treatments. These models will help us to ask the right ...
- Spheroids, Organoids Replacing Standard Cultures for Cell-Based Assayson November 3, 2020 at 4:00 am
Corning Life Sciences maintains that 3D cell cultures better capture in vivo conditions and are poised to improve drug screening Three-dimensional (3D) cell culture overcomes many shortcomings of ...
- Engineering Mucosal Barriers: From Organoids to Organs-on-Chipson November 2, 2020 at 4:03 am
Mucosal barriers are the gateways to all internal organs, serving to transport oxygen, nutrients, and waste and at the same time performing enormous feats of protection against infection and other ...
- Mini-Lungs In A Dish, Airway Stem Cells, Evolution of Virus Mutations: COVID-19 Updateson October 30, 2020 at 7:50 am
October 30, 2020 I Neutrons chart atomic map of COVID-19’s viral replication, Organs-on-Chips technology, coronaviruses mimic proteins that control blood coagulation and inflammation, therapeutic ...
- How Organs on Chips Tech Is Making Strideson October 29, 2020 at 5:00 pm
Emulate, based in Boston, just raised $28 Million to commercialize its organs-on-chips technology into a lab-ready system aimed at improving drug development and consumer product design. The automated ...
- Researching the Effects of Space Radiation with Organs on Chipson August 9, 2020 at 8:02 am
Space Health Spotlight - Gordana Vunjak-Novakovic, Ph.D. Content Radiation is a type of energy that is emitted in the form of rays, electromagnetic waves and/or particles. In low doses, radiation can ...
via Google News and Bing News