A simple methodology for capturing proteins implicated in the development of Alzheimer’s disease and other conditions has been developed by researchers at the University of Bradford and University of Dundee.
The new methodology involves easily trapping proteins that bear a specific modification that can provide potential markers for conditions. The specific modification is based on sugar and when attached to a protein affects how the protein functions. Protein modification is a normal, carefully regulated cellular function, but in some instances this can go wrong.
Alzheimer’s, along with other conditions including cancers, type 2 diabetes, and cardio-vascular disease, is affected by dysregulation (abnormal or imperfect regulation) of these sugar modifications to proteins. Identifying such proteins is a key step in understanding their involvement in these various conditions.
The newly developed methodology could open the way for treatments that target these protein alterations, and ultimately the condition.
Previously, capturing these proteins has been very difficult as the sugar modification was prone to falling off the protein. In order to capture them, researcher’s required highly specialised laboratory equipment and extensive validation of identified proteins. This new method is simple and can be carried out by any laboratory, opening the way to rapid identification of proteins involved in the development of a number of diseases.
It also opens up the possibilities for therapies to be developed to target specific proteins identified as being aberrantly modified in these disease processes.
The methodology involves growing a protein with an engineered tail that grabs the sugar-modified protein only. This can then be added to complex protein mixtures obtained from tissue. The modified tail is then used as a handle to pull out all proteins that bear the sugar modification and so separate those proteins that have the modification from those that do not. These proteins can then be identified using several different routine laboratory techniques.
Dr Ritchie Williamson of the University of Bradford said: “This methodology represents a major step forward. We are now in a position where we can easily trap the proteins we need to target. If we can do this we can then identify the proteins which we think may be involved in the disease process. We also have the potential to find biomarkers, especially in younger people, and to probe different diseases.”
The Latest on: Early test for Alzheimer’s
via Google News
The Latest on: Early test for Alzheimer’s
- Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s diseaseon June 26, 2020 at 4:40 am
Neurofilament light chain (NFL) measurement has been gaining strong support as a clinically useful neuronal injury biomarker for various neurodegenerative conditions. However, in Alzheimer’s disease ...
- Ask the Doctors: Eye tracking tests may help diagnose Alzheimer'son June 25, 2020 at 10:00 am
Dear Doctor: I've heard that there's finally a test for Alzheimer's disease ... We don't yet have a cure for Alzheimer's disease, but early intervention has been linked to better outcomes for ...
- Japanese team to start trial of blood test to find dementia in Juneon June 25, 2020 at 3:03 am
A Japanese research team will begin a clinical trial this month of a blood test for early diagnosis of Alzheimer's disease by detecting abnormal proteins linked to it. The team, which aims to put the ...
- 'Game changing' coronavirus antibody test faces expert scrutinyon June 24, 2020 at 3:47 pm
A group of doctors has questioned how “game changing” coronavirus antibody tests really are. Boris Johnson praised their potential early in the outbreak, with the government later buying 10 million of ...
- Silver Alert issued for missing Lakeland woman with dementiaon June 24, 2020 at 5:28 am
(WFLA) – A Silver Alert was issued Wednesday morning for a missing Lakeland woman with dementia. Investigators suspect Linda Diann Davis, 72, left her home in the 1200 block of Pine Bend Drive in the ...
- A Morning Hater's Guide to Crushing Early Startson June 24, 2020 at 3:15 am
Can starting your day before dawn will earn you a spot among the high-achievers, and do the hours you keep make a difference? This night owl spent a month transforming himself into an early bird ...
- An app for football fans became a digital contact tracing tool — and could be a litmus test for Covid-19 technologyon June 24, 2020 at 2:40 am
North Dakota's pilot effort will serve as a crucial test of whether digital tools can play any sort of permanent role in the pandemic response.
- Watercrest Newnan Assisted Living and Memory Care Achieves 100% Negative Test Results for COVID-19on June 23, 2020 at 11:38 am
Since the onset of the COVID-19 pandemic this spring, the team at Watercrest Newnan Assisted Living and Memory Care have proven that their residents are always their top priority. The Watercrest team ...
- Holding on and holding still, a son photographs his father with Alzheimer'son June 19, 2020 at 5:26 am
In 1985, when Stephen DiRado was just a few years out of college, he bought his first large-format, 8x10 camera. Since each exposure cost eight bucks in today’s dollars, the process required ...
via Bing News