Combined blood markers correctly detect early pancreatic cancer in human cancer cells
A newly identified biomarker panel could pave the way to earlier detection and better treatment for pancreatic cancer, according to new research from the Perelman School of Medicine at University of Pennsylvania. Currently over 53,000 people in the United States are diagnosed with pancreatic cancer — the fourth leading cause of cancer death — every year. The blood biomarkers, detailed today in Science Translational Medicine, correctly detected pancreatic cancer in blood samples from patients at different stages of their disease.
The majority of pancreatic cancer patients are not diagnosed until an advanced stage, beyond the point at which their tumors can be surgically removed.
A team led by Ken Zaret, PhD, director of the Penn Institute for Regenerative Medicine and the Joseph Leidy Professor of Cell and Developmental Biology, and Gloria Petersen, PhD, from the Mayo Clinic, identified a pair of biomarkers that physicians could soon use to discover the disease earlier.
“Starting with our cell model that mimics human pancreatic cancer progression, we identified released proteins, then tested and validated a subset of these proteins as potential plasma biomarkers of this cancer,” Zaret said. The authors anticipate that health care providers will use the early-detection biomarkers to test for their presence and levels in blood from pancreatic cancer patients and blood drawn from individuals with a high risk of developing pancreatic cancer, including those who have a first-degree relative with pancreatic cancer, are genetically predisposed to the disease, or who had a sudden onset of diabetes after the age of 50.
“Early detection of cancer has had a critical influence on lessening the impact of many types of cancer, including breast, colon, and cervical cancer. A long standing concern has been that patients with pancreatic cancer are often not diagnosed until it is too late for the best chance at effective treatment,” said Robert Vonderheide, MD, DPhil, director of the Abramson Cancer Center (ACC) at the University of Pennsylvania. “Having a biomarker test for this disease could dramatically alter the outlook for these patients.”
Novel method for discovering pancreatic cancer biomarkers
Credit: The lab of Ken Zaret, Perelman School of Medicine, University of Pennsylvania
The biomarker panel, enabled by discovery work of first author Jungsun Kim, PhD, a postdoctoral fellow in Zaret’s lab, builds on a first-of-its-kind human-cell model of pancreatic cancer progression the lab described in 2013. They used stem-cell technology to create a cell line from a patient with advanced pancreatic ductal adenocarcinoma. Genetically reprogramming late-stage human cancer cells to a stem-cell state enabled them to force the reprogrammed cells to progress to an early cancerous state, revealing secreted blood biomarkers of early-stage disease along the way.
The best candidate biomarker, plasma thrombospondin-2 (THBS2), was screened against 746 cancer and control plasma samples using an inexpensive, commercially available protein-detection assay. The team found that blood levels of THBS2, combined with levels of a known later-stage biomarker called CA19-9, was reliable at detecting the presence of pancreatic cancer in patients.
The team refined the assay with independent investigations of plasma samples from patients with different stages of cancer, from individuals with benign pancreatic disease, and from healthy controls, all obtained from Petersen, who directs the biospecimen resource program for pancreas research at the Mayo Clinic.
“Positive results for THBS2 or CA19-9 concentrations in the blood consistently and correctly identified all stages of the cancer,” Zaret said. “Notably, THBS2 concentrations combined with CA19-9 identified early stages better than any other known method.” The combination panel also improved the ability to distinguish cases of cancer from pancreatitis. The panel will next be validated in a set of samples from pancreatic cancer patients who provided a research blood sample prior to their diagnosis.
The Latest on: Pancreatic cancer
- Alex Trebek, who is battling pancreatic cancer, sends ‘Jeopardy!’ fans a hopeful message on April 17, 2019 at 10:01 pm
Alex Trebek signed off following the final day of taping for the 35th year of “Jeopardy!”, and he told fans of the popular game show that he planned to return later this year for another season of ... […]
- Achilles’ heel of pancreatic cancer may lead to improved patient treatment on April 17, 2019 at 9:14 pm
Scientists may have discovered the “Achilles’ heel” of pancreatic cancer – a condition which is notoriously difficult to treat. Researchers believe a protein called leukaemia inhibitory factor (LIF) ... […]
- Alex Trebek says he's 'feeling good' amid cancer battle, plans to host 'Jeopardy!' season 36 on April 17, 2019 at 6:54 pm
FOX NEWS - Cancer won't slow down "Jeopardy!" host Alex Trebek. He's filmed 50 episodes since being diagnosed with pancreatic cancer in March and in a new video update to fans on Wednesday, said he's ... […]
- WATCH: ‘Jeopardy’ host Alex Trebek gives update on his progress after pancreatic cancer diagnosis. ‘I’m touched beyond words.’ on April 17, 2019 at 6:37 pm
When Alex Trebek announced in March that he had been diagnosed with stage 4 pancreatic cancer, “Jeopardy!" fans rallied to support him. Trebek vowed to stay on the job, even as he sought treatment — ... […]
- Dr. Tempero on Role of Molecular Profiling in Pancreatic Cancer on April 17, 2019 at 3:02 pm
Margaret A. Tempero, MD, director, University of California, San Francisco (UCSF) Pancreas Center, professor of medicine, Division of Hematology and Oncology, Rombauer Family Distinguished Professor ... […]
- Some Dying Cancer Patients Still Receive Active Therapies on April 17, 2019 at 1:30 pm
Older patients with lung cancer were less likely to receive radiotherapy. The odds of receiving chemotherapy and radiotherapy were also lower for lung and pancreatic cancer patients who had higher ... […]
- New study targets Achilles' heel of pancreatic cancer, with promising results on April 17, 2019 at 1:00 pm
Advanced pancreatic cancer is often symptomless, leading to late diagnosis only after metastases have spread throughout the body. Now, researchers have uncovered the role of a signaling protein, ... […]
- 'Mami's Message' to raise money for pancreatic cancer research on April 17, 2019 at 11:34 am
Natalia Piferrer and her mother used to spend every birthday going out to dinner and making wishes on candles. This year, Piferrer will spend her mother’s birthday making with another wish: to raise ... […]
- Key protein a possible new target in the treatment of pancreatic cancer on April 17, 2019 at 10:21 am
WOODBURY, N.Y., April 17, 2019 -- Pancreatic cancer can be difficult to treat and often responds poorly to chemotherapy due to the presence of tumor cells located within the dense protective tissue, ... […]
- Neoadjuvant Strategy Improves Survival in Pancreatic Cancer Resection on April 15, 2019 at 12:42 pm
Researchers sought to identify predictive factors associated with morbidity, mortality, and survival outcomes in patients with BR or LA PDAC who undergo TNT prior to surgical resection. Pancreatic ... […]
via Google News and Bing News