The human whipworm, which infects 500 million people and can damage physical and mental growth, is killed at egg and adult stage by a new drug class developed at the Universities of Manchester and Oxford and University College London.
Current treatments for human whipworm are based on 1960s drugs initially developed for livestock and have a low success rate in people. There are also no vaccines available.
As a result there’s a desperate need for new treatments. The team from the three UK universities, whose results have been published in the journal PLOS Neglected Tropical Diseases, studied a class of dihydrobenzoxazepinones, not previously associated with controlling whipworms.
The researchers found that the compounds kill the adult stages of the whipworm much more effectively than existing drugs.
Parasite immunologist, Professor Kathryn Else from The University of Manchester said: “Eradicating the whipworm requires more effective drugs, improving hygiene and vaccine development. The compounds we have discovered could address the first two of these.”
Although we rarely see whipworm infection in the UK, it is a serious and damaging problem in many parts of the world and if we can develop this treatment, the lives of many people could be improved
Professor Kathryn Else
Whipworm eggs are also affected by the compounds. Whipworm eggs are passed from infected faeces into people by hand to mouth contact. This often happens in unsanitary toilets or areas where people live close together. The eggs are highly resistant to extreme temperature changes and ultraviolet radiation and can remain viable in the environment for many years.
However the new compounds are effective against the eggs and could be developed into a spray which can stop infection at source.
The researchers are now modifying their compounds to make them effective enough for a treatment in humans, and one that can be turned into a product used in the developing countries most affected.
Professor Else said: “This team brought expertise from immunology, medicinal chemistry and neurobiology and really shows how combining across disciplines and institutions can lead to important new discoveries.
“Although we rarely see whipworm infection in the UK, it is a serious and damaging problem in many parts of the world and if we can develop this treatment, the lives of many people could be improved.”
Receive an email update when we add a new HUMAN WHIPWORM article.
The Latest on: Human whipworm
via Google News
The Latest on: Human whipworm
- Leaving too much behindon March 21, 2020 at 5:59 pm
No buts about it, cigarette ends are the most littered item in New River Valley town parks. In the world too, according to some estimates. During the coronavirus pandemic, parks are great places to go ...
- WHO calls for urgent de-worming interventions to stop Neglected Tropical Diseases and malnutrition in the Sahel and Central Africaon March 15, 2020 at 5:00 pm
The diseases, which include river blindness, schistosomiasis, blinding trachoma, human African trypanosomiasis or sleeping ... commonly known as hookworm, roundworm, and whipworm. NTDs coexist with ...
- Mouse poisons kill pets and wildlife (Ask the Vet)on March 13, 2020 at 2:11 am
Dogs and humans also share some species of tapeworms, which can cause liver and lung problems in humans. Some monthly heartworm preventives kill tapeworms, too. Whipworms also infect dogs, and they're ...
- Fenbendazole Market 2020 Sales, Size, Benefits, Developments, Business Opportunities and Future Investmentson March 5, 2020 at 3:29 am
Fenbendazole is a broad spectrum anthelmintic drug of class benzimidazole. Fenbendazole is used to remove certain gastrointestinal parasites from stomach and intestines of animals. It is effective ...
- Ancient Britons had giant worms in their kidneys, study showson August 23, 2019 at 8:17 am
Also infecting animals were pig whipworm and Capillaria worm, so it seems that everything in the area-- human or animal-- had some kind of parasite to deal with. Still, while the findings of ...
- How the parasitic worm has turnedon September 23, 2018 at 1:24 pm
Whipworm, also known as Trichuris, is a very common type of parasitic worm and infects many species of animals including millions of humans. It has also been with us and animals throughout evolution.
- Prevalence of Ascarids, Hookworms, and Whipworms in the Area of the Prefecture of Thessaloniki, Greeceon February 18, 2018 at 10:25 pm
Haralabidis S. T. Parasitic diseases of the animals and human. University Studio Press. Thessaloniki. 2003. 3. Vanparijs O., Herman L., van der Flaes L. 1991, Helminth and protozoan parasites in dogs ...
- The Iceman's Last Mealon August 26, 2017 at 8:38 pm
Oeggl also found the eggs of the human whipworm. Many people alive today who do not live in areas with flush toilets also carry the worm, which can cause unpleasant symptoms like stomach ache and ...
- IBD: Understanding the Gastrointestinal Systemon January 30, 2015 at 4:55 am
Sandborn, MD, director of UC San Diego Health’s IBD Center, to explore the condition. Q: What are your thoughts about some of the more unusual or exotic treatments being proposed or tested for IBD, ...
via Bing News