One of the outstanding issues of modern medicine is to combat pain effectively. Jose Vicente Torres Pérez, a Spanish researcher who works at Imperial College in London, set out to curb the suffering of people with serious burns.
Torres found that blocking a new genetic marker can reduce the neural activation caused by painful stimuli.
As Torres, the only Spanish researcher participating in the study published today in the journal ‘Scientific Reports’, explains to SINC: “The cell activation markers most used today are pERK1/2 and c-Fos, but both have their limitations.”
The development and persistence of pain depends on plastic changes to the neurons that process information on noxious stimuli, which are those of the dorsal spinal cord.
These plastic changes are largely regulated by epigenetic mechanisms, i.e. chemical changes that alter the expression of the genes, but not their sequence, such as post-translational modifications of histones.
“Seeking new pain markers continues to be very important in the field of nociception, which analyses the subjective experience of pain, and a need that has not yet been met,” adds Torres Pérez.
New pain relief therapy
Technically, the team in which the Spanish expert works has demonstrated in mice that a population of superficial neurons in the spinal cord controls an epigenetic marker known as pS10H3.
“We observed the effect after using various animal pain models: inducing burns, applying capsaicin or electrical nerve stimulation,” explains Torres Pérez. Therefore, the authors believe that, if this activation is blocked, they will achieve a new pain relief therapy.
For the Spanish researcher, “pS10H3 is a new marker of pain processing in neurons on the spinal cord, and the changes caused by it are fundamental to normal pain development, which opens up new therapeutic possibilities.”
Application to burn victims
Recent advances have significantly increased the survival rates of burn victims, but little has been achieved to alleviate the pain they suffer.
According to the authors, advances that help to decipher the molecular mechanisms produced in neurons that are key to processing pain – such as the discovery of this alteration – will help to find new therapeutic strategies.
“We propose that blocking this epigenetic modification could be a new strategy to try to reduce or completely eliminate the pain after these processes,” Torres Pérez concludes.
Receive an email update when we add a new EPIGENETICS article.
The Latest on: Epigenetics
via Google News
The Latest on: Epigenetics
- Epigenetics Market Overview & Potential Growth Opportunities Report To 2025 | Key Players: Illumina, Abcam, Novartis, Merck &on October 29, 2019 at 2:27 am
Epigenetics Market Overview & Potential Growth Opportunities Report To 2025 | Key Players: Illumina, Abcam, Novartis, Merck & Oncolys Biopharma | Million Insights PR Newswire FELTON, California, Oct.
- Epigenetics Market Overview & Potential...on October 29, 2019 at 2:20 am
FELTON, California, Oct. 29, 2019 /PRNewswire/ -- The global Epigenetics Market is expected to value at USD 22.05 billion in 2025, exhibiting a CAGR of 19.7% during the forecast period of 2018 to 2025 ...
- Epigenetic regulation of macrophages: from homeostasis maintenance to host defenseon October 29, 2019 at 1:40 am
Among them, epigenetics now arises as a key controller of macrophage activity. Epigenetics regulates the expression of DNA-encoded information and determines the specific “identity” of a cell while ...
- How epigenetics and stress impact human performanceon October 28, 2019 at 1:40 am
We all know someone like Sonya. What Sonya is going through in her life is stress. But what we do not know is that whatever is happening to Sonya can be explained through a relatively new field in ...
- The Real Story About Organoids: What You Should Know About “Brains In A Dish”on October 26, 2019 at 10:40 pm
professor at the University of Pennsylvania Perelman School of Medicine who studies neurogenesis and epigenetics. That is not, however, the same as saying they are human brains. Rather, organoids ...
- Epigenetics Market : Opportunities and Challengeson October 25, 2019 at 3:05 pm
The growth in this market is primarily attributed to decreasing sequencing costs, increasing research activity, funding for epigenetics research, rising prevalence of cancer and growing applications ...
- Is Your DNA Your Destiny? A Primer on Epigeneticson October 24, 2019 at 3:00 am
Why do patients with genes that seem to predispose them to cancer and other diseases often escape what might seem to have been their genetic destiny? The science of epigenetics is an intriguing ...
- At 13.6% CAGR, Epigenetics Market Size to Cross $ 2,611.57 Mn by 2025on October 23, 2019 at 11:23 pm
Oct 24, 2019 (AmericaNewsHour) -- MarketStudyReport.com Adds New Epigenetics Market 2018 - 2025 research report providing information and data by Product, Technology, Application, End Users, Geography ...
- Successful treatment of post-traumatic stress disorder reverses DNA methylation markson October 23, 2019 at 7:30 am
Daskalakis NP, Rijal CM, King C, Huckins LM, Ressler KJ. Recent genetics and epigenetics approaches to PTSD. Curr. Psychiatry Rep. 2018;20:30. Zannas AS, Provencal N, Binder EB. Epigenetics of ...
via Bing News