Oregon State University researchers have developed a new weapon in the battle against antibiotic-resistant germs – a molecule that neutralizes the bugs’ ability to destroy the antibiotic.
Scientists at OSU were part of an international collaboration that demonstrated the molecule’s ability to inhibit expression of an enzyme that makes bacteria resistant to a wide range of penicillins.
The molecule is a PPMO, short for peptide-conjugated phosphorodiamidate morpholino oligomer. The enzyme it combats is known as New Delhi metallo-beta-lactamase, or NDM-1, and it’s accompanied by additional genes that encode resistance to most if not all antibiotics.
“We’re targeting a resistance mechanism that’s shared by a whole bunch of pathogens,” said Bruce Geller, professor of microbiology in OSU’s College of Science and College of Agricultural Sciences, who’s been researching molecular medicine for more than a decade. “It’s the same gene in different types of bacteria, so you only have to have one PPMO that’s effective for all of them, which is different than other PPMOs that are genus specific.”
The Oregon State study showed that in vitro the new PPMO restored the ability of an antibiotic — in this case meropenem, an ultra-broad-spectrum drug of the carbapenem class — to fight three different genera of bacteria that express NDM-1. The research also demonstrated that a combination of the PPMO and meropenem was effective in treating mice infected with a pathogenic strain of E. coli that is NDM-1 positive.
Results of the study, supported by a grant from the National Institutes of Health, were recently published in the Journal of Antimicrobial Chemotherapy.
Geller says the PPMO will likely be ready for testing in humans in about three years.
“We’ve lost the ability to use many of our mainstream antibiotics,” Geller said. “Everything’s resistant to them now. That’s left us to try to develop new drugs to stay one step ahead of the bacteria, but the more we look the more we don’t find anything new. So that’s left us with making modifications to existing antibiotics, but as soon as you make a chemical change, the bugs mutate and now they’re resistant to the new, chemically modified antibiotic.”
That progression, Geller explains, made the carbapenems, the most advanced penicillin-type antibiotic, the last line of defense against bacterial infection.
“The significance of NDM-1 is that it is destroys carbapenems, so doctors have had to pull out an antibiotic, colistin, that hadn’t been used in decades because it’s toxic to the kidneys,” Geller said. “That is literally the last antibiotic that can be used on an NDM-1-expressing organism, and we now have bacteria that are completely resistant to all known antibiotics. But a PPMO can restore susceptibility to antibiotics that have already been approved, so we can get a PPMO approved and then go back and use these antibiotics that had become useless.”
Receive an email update when we add a new ANTIBIOTIC RESISTANCE article.
The Latest on: Antibiotic resistance
via Google News
The Latest on: Antibiotic resistance
- CHEXF: Initiating Coverage of Avivagen, Inc.; Combating Antibiotic Resistance at the Source…on November 19, 2019 at 4:08 pm
Antibiotic resistance is a growing worldwide public health problem, and since 80% of antibiotics are used in livestock feeds in the U.S., replacement of antibiotics in animal feed may help alleviate ...
- Houston Health Department Addresses Antibiotic Resistanceon November 19, 2019 at 2:12 pm
HOUSTON - The Houston Health Department is expanding its efforts to address antibiotic resistance, one of the most urgent threats to the public's health. Antibiotic resistance happens when the overuse ...
- Why the CDC warns antibiotic-resistant fungal infections are an urgent health threaton November 19, 2019 at 2:02 pm
Surgeons operated to remove the abscess. Two days later, test results revealed that the abscess was caused by a fungus called Candida that was resistant to echinocandins, our most powerful drugs ...
- OpGen Products in Development to Address "Urgent Threat" Pathogens Highlighted in New CDC Report on Antibiotic Resistance Threatson November 19, 2019 at 3:30 am
Nov. 19, 2019 (GLOBE NEWSWIRE) -- OpGen, Inc. OPGN, -2.53% announced today that the Center for Disease Control (CDC) has released updated data increasing the number of deaths in the United States (U.S ...
- CDC expert: 'Antibiotic resistance is worse than we previously thought'on November 18, 2019 at 10:38 am
A superbug, otherwise known as an antibiotic-resistant infection, can be potentially lethal. And according to a new CDC report, there are more than 2.8 million superbugs in the U.S. each year, with ...
- The rise of superbugs: Facing the antibiotic resistance crisison November 18, 2019 at 9:05 am
While medical research has helped us overcome many health threats, we now face a new type of crisis: Many dangerous bacteria are becoming resistant to the drugs meant to fight them. Where do we go ...
- Antibiotic Resistance: Rise Of Bacteria That Are Resistant To Antibiotics Alarms Medical Practitionerson November 18, 2019 at 3:10 am
Antibiotic resistance seems to create a growing problem among medical practitioners all over the world. Ailments that were once easy to treat have become unmanageable. Doctors explain that bacteria ...
- In the fight to slow antibiotic resistance, an ounce of prevention is worth a pound of cureon November 16, 2019 at 5:26 am
Healthy animals lead to healthy food. As if that weren’t enough, CVB has the potential to play a critical role in the global fight against antibiotic resistance. We all agree that antibiotic ...
- CDC Report Finds 35,000 Americans Die of Antibiotic-Resistant Infections Each Yearon November 15, 2019 at 10:19 am
An estimated 35,000 Americans die of antibiotic-resistant infections each year—one every 15 minutes—according to a stark new report from the Centers of Disease Control and Prevention that reveals that ...
via Bing News