Novel Drug May Help Repair Failing Hearts
Cimaglermin, a new experimental drug, may help restore cardiac function after heart failure, according to a first-in-man study published today in JACC: Basic to Translational Science.
Heart failure, characterized by a loss of cardiac function, is among the leading causes of death worldwide. A significant portion of heart failure patients, particularly those with severe left ventricular systolic dysfunction, do not sufficiently respond to current medical therapy.
Researchers examined the safety and efficacy of a single infusion of cimaglermin, which acts as a growth factor for the heart, helping the structural, metabolic and contractile elements of the heart to repair itself following injury. The study enrolled 40 heart failure patients who were taking optimal medical therapy for at least three months prior to the trial. Compared to patients who received a placebo, patients who received a high dose of cimaglermin had a sustained increase in left ventricular ejection fraction, or pumping capacity, through 90 days after dosing, with the maximum increase reached at day 28.
“These findings support continued clinical development of the investigational drug cimaglermin, including further safety evaluations and detailing the potential improvement on clinical heart failure outcome measures,” said Daniel J. Lenihan MD, from the division of cardiovascular medicine at Vanderbilt University and the lead author of the study. “As with all experimental therapeutics, additional studies will be required and subject to regulatory review to determine if the relative risks and benefits of cimaglermin warrant approval.”
The most common side effects were headache and nausea, which were temporarily associated with exposure to the drug. One patient receiving the highest planned dose of cimaglermin experienced an adverse reaction that met the stopping criteria of Federal Drug Administration guidance for drug induced liver injury.
Limitations of this study include the small sample size and the fact that patients only received a single infusion rather than multiple doses.
“Although the results of the study must be regarded as provisional because of the small numbers of patients, the results of this study are nonetheless very exciting,” said Douglas L. Mann, MD, FACC, editor-in-chief of JACC: Basic to Translational Science. “Instead of blocking the fundamental mechanisms that lead to cardiac injury, the early results with cimaglermin suggest that it may also be possible to administer therapeutics that allow the failing heart to repair itself using its own repair mechanisms. If the results of this study can be replicated and translated into improvements in clinical outcomes in larger numbers of patients in phase II and III clinical trials, it will represent a paradigm shift in the way in which clinicians treat patients with heart failure.”
Learn more: Novel Drug May Help Repair Failing Hearts
Receive an email update when we add a new HEART FAILURE article.
The Latest on: Restore cardiac function
via Google News
The Latest on: Restore cardiac function
- Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibitionon July 3, 2019 at 2:06 am
Although optimal therapy for myocardial infarction includes reperfusion to restore blood flow to the ischemic region ... The improvement in cardiac function can also be seen in the mitigated extent of ... […]
- Dr. Jeffrey Morgan Discusses the Reality of Bioprinted Hearts for Patients With Advanced Heart Failureon June 26, 2019 at 8:13 am
HOUSTON, TX / ACCESSWIRE / June 25, 2019 / Cardiac surgeon and Chief ... structures with the potential to restore, improve, or replace existing organ function. Dr. Jeffrey Morgan explains how ... […]
- Tucson Medical Center offers minimally invasive alternatives to open heart surgeryon June 26, 2019 at 7:00 am
TMC has performed over 400 minimally invasive aortic valve replacements to restore proper valve function in the heart. The procedure — called transcatheter aortic valve replacement — reduces ... […]
- Embryonic microRNA fuels heart cell regeneration, Temple researchers showon June 21, 2019 at 3:21 pm
A new study by scientists at the Lewis Katz School of Medicine at Temple University (LKSOM), however, shows that it may be possible to reverse this damage and restore heart function, even after a ... […]
- Type 2 diabetes: High-intensity exercise may restore heart functionon June 3, 2019 at 3:05 am
Type 2 diabetes can sometimes result in a loss of heart function. However, the results of a new study suggest this function may be recovered through high-intensity exercise. With insulin unable to ... […]
- High-intensity workout linked to better heart function in type 2 diabetes patientson May 26, 2019 at 12:40 pm
a new study has found that high-intensity workout sessions can also help to restore heart function in people with type 2 diabetes. Genevieve Wilson carried out the study under the supervision of Dr ... […]
- High-intensity workout linked to better heart function in type 2 diabetes patientson May 26, 2019 at 9:43 am
a new study has found that high-intensity workout sessions can also help to restore heart function in people with type 2 diabetes. The study was published in the journal 'Medicine and Science in ... […]
- High-intensity exercise may restore heart function in people with type 2 diabeteson May 24, 2019 at 8:33 am
Researchers have discovered that high-intensity exercise can reduce or reverse the loss in heart function caused by type 2 diabetes. The study found that three months of high-intensity interval ... […]
via Bing News