A ‘living bandage’ made from stem cells, which could revolutionise the treatment and prognosis of a common sporting knee injury, has been trialled in humans for the first time by scientists at the Universities of Liverpool and Bristol.
Meniscal tears are suffered by over one million people a year in the US and Europe alone and are particularly common in contact sports like football and rugby. 90% or more of tears occur in the white zone of meniscus which lacks a blood supply, making them difficult to repair. Many professional sports players opt to have the torn tissue removed altogether, risking osteoarthritis in later life.
The Cell Bandage has been developed by spin-out company Azellon, and is designed to enable the meniscal tear to repair itself by encouraging cell growth in the affected tissue.
A prototype version of the Cell Bandage was trialled in five patients, aged between 18 and 45, with white-zone meniscal tears. The trial received funding support from Innovate UK and the promising results have been published today in the journal Stem Cells Translational Medicine.
The procedure involved taking stem cells, harvested from the patient’s own bone marrow, which were then grown for two weeks before being seeded onto a membrane scaffold that helps to deliver the cells into the injured site. The manufactured Cell Bandage was then surgically implanted into the middle of the tear and the cartilage was sewn up around the bandage to keep it in place.
All five patients had an intact meniscus 12 months post implantation. By 24 months, three of the five patients retained an intact meniscus and had returned to normal knee functionality whilst the other two patients required surgical removal of the damaged meniscus due to a new tear or return of symptoms.
Professor Anthony Hollander, Chair of Stem Cell Biology at the University of Liverpool and Founder and Chief Scientific Officer of Azellon, said: “The Cell Bandage trial results are very encouraging and offer a potential alternative to surgical removal that will repair the damaged tissue and restore full knee function.
“We are currently developing an enhanced version of the Cell Bandage using donor stem cells, which will reduce the cost of the procedure and remove the need for two operations.”
The Cell Bandage was produced by the Advanced Therapies Unit at the NHS Blood & Transplant facility in Speke, Liverpool and implanted into patients at Southmead Hospital in Bristol, under the supervision of Professor Ashley Blom, Head of Orthopaedic Surgery at the University of Bristol.
Professor Blom commented: “The Cell Bandage offers an exciting potential new treatment option for surgeons that could particularly benefit younger patients and athletes by reducing the likelihood of early onset osteoarthritis after meniscectomy.”
A spokesperson for Innovate UK said: “Turning stem cell research into clinical and commercial reality requires close collaboration between businesses, universities, and Hospitals. It’s great to see this inter-disciplinary approach has led to such an exciting outcome from this first-in-human trial.”
The paper ‘Repair of torn avascular meniscal cartilage using undifferentiated autologous mesenchymal stem cells: from in vitro optimisation to a first-in-human study is published in Stem Cells Translational Medicine.
Receive an email update when we add a new LIVING BANDAGE article.
The Latest on: Living bandage
via Google News
The Latest on: Living bandage
- Man Feared to Be Serial Killer Says He Was Doing God's Work in Allegedly Slaying 3 Strangerson October 16, 2019 at 11:01 am
With his hands behind his back and a bloody bandage on his forehead, Mossburg at times shook his head and smiled ... After 14 hours of being captive, the living victim escaped from the house Monday ...
- Singer Garth Brooks speaks out after working with fmr president Jimmy Carteron October 9, 2019 at 5:00 pm
Brooks was one of many who praised America’s oldest living president after he was spotted this week at a building site in Nashville with a bandage on his head. Jimmy Carter needed stitches after ...
- Jimmy Carter builds Habitat for Humanity home in Tennessee despite black eye, stitches from fallon October 8, 2019 at 6:17 pm
But the oldest living U.S. president didn’t let the injury keep him ... appeared at the build site with his left eye swollen and bruised. He had a white bandage above his eye. His wife, former First ...
- Despite 14 stitches and a black eye, Jimmy Carter is back building homeson October 8, 2019 at 1:30 pm
Fourteen stitches, a black eye and a large bandage are no match for former President Jimmy Carter, who turned 95 last week. Just hours after suffering injuries from a fall in his home Sunday morning, ...
- Despite fall, Jimmy Carter back to building homeson October 8, 2019 at 7:52 am
(CNN) - Fourteen stitches, a black eye and a large bandage are no match for former President Jimmy Carter, who turned 95 last week. Just hours after suffering injuries from a fall in his home Sunday ...
- 'Smart Bandage' Detects Pressure Ulcers Before They are Visibleon October 3, 2019 at 5:00 pm
"This bandage could provide an easy early-warning system that would ... "Our device is a comprehensive demonstration that tissue health in a living organism can be locally mapped using impedance ...
- Healthy Living: Electrical Bandageson September 20, 2019 at 2:04 pm
Researchers have created a bandage-like device that can seal up wounds in a revolutionary way. In Healthy Living, Courtney Hunter explains how this device could be the next big thing in modern ...
- Probiotic hydrogels heal gut wounds other bandages can't reachon August 13, 2019 at 4:18 am
"This new type of engineered living material with its ease of production and storability ... use in endoscopic procedures to treat intestinal disorders, like a spray-on bandage," said Karp, who is a ...
- New fetal skin-inspired bandage capable of treating any woundon July 25, 2019 at 5:00 pm
During tests on pig and mouse skin, the dressings closed up wounds much quicker than conventional bandages and also lessened the time required to heal. No inflammation or immune system response, ...
via Bing News