A new model can predict drug interactions and side effects even between a large number of components
Drug cocktails such as those for treating cancer, like the alcoholic versions offered at the local bar, are best when the proper ingredients are mixed in the right proportions.
Like the cocktails we normally drink, the combination of ingredients can be better than the sum of its parts – or it can leave us with unwanted side effects.
A new model developed in the group of Prof. Uri Alon of the Weizmann Institute of Science’s Molecular Cell Biology Department can simplify the process of identifying the optimal blends for drug cocktails – even when a large number of ingredients is called for.
Drug cocktails – both antibiotic and anti-cancer – are increasingly used, among other things, because simultaneously attacking pathogenic cells with several different methods can reduce the risk of drug resistance.
Doctors and pharmaceutical companies are interested in the advance of drug “Mixology” because it can help create novel applications for existing drugs, since new ones are costly to develop and slow to reach the market.
Adding drugs together does not generally result just in the sum of their effects.
One drug can alert mechanisms in a cell that pump the other drugs out of the cell, thus changing the dose at which the other drugs will be effective.
Conversely, side effects can add up, so researchers often want to identify the lowest possible dose of any given drug.
With typically four or more drugs added together in chemotherapy cocktails, the number of possible combinations and doses is astronomical: It would be impossible to test them all to arrive at the optimal mix.
Because of the combinatorial explosion problem, say research students Anat Zimmer and Itay Katzir, who led the study, drug cocktails are often concocted without any good way of predicting the end result.
Their method requires only a small number of measurements on drug pairs.
The tests are conducted on human cancer cells or bacteria grown in lab dishes.
The group tested each drug – separately and in pairs – to understand the effects at several different doses.
This enabled the researchers to determine how drug A affects the actions of B, and vice versa, and the new mathematical model the group developed was then extrapolated to predict the interactions among three, four and more drugs in combination.
Further testing showed that the model performs better than existing methods of dealing with the combinatorial explosion problem.
Thus researchers using the model would not need to test every possible combination to arrive at the optimal doses in drug cocktails.
“There is an urgent demand for methods that can predict how drug cocktails will work,” says Katzir.
“This model may take much of the expensive guesswork out of the process of developing such cocktails.”
“The model might prove especially useful for personalized medicine – for example, in cancer – because each tumor can react differently to the same drugs,” adds Zimmer.
“It provides a way to mix that perfect cocktail without having to try out all of the possible combinations.”
Learn more: How to Mix the Perfect Cocktail
Receive an email update when we add a new DRUG INTERACTION article.
The Latest on: Drug interaction
via Google News
The Latest on: Drug interaction
Study links customized drug alerts to improved patient safety
on February 20, 2019 at 7:34 am
Researchers made changes to drug interaction alerts received by clinicians at St. Jude Children's Research Hospital in Memphis, Tenn., and found 40% lower alert overrides. […]
Carefully Assess Opioid Drug Interaction Risks
on February 19, 2019 at 2:36 pm
Pharmacists and prescribing clinicians have entered a new era in opioid prescribing and dispensing. The recent Centers for Medicare & Medicaid Services’ A Prescriber’s Guide to the New Medicare Part D ... […]
Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes
on February 19, 2019 at 11:41 am
3 Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA. 4 Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University, Nashville, TN 37232, U... […]
Drug lord El Chapo is likely going to ‘the prison of all prisons,’ a Supermax in Colorado
on February 18, 2019 at 11:33 pm
Drug lord Joaquin Guzman has an unparalleled record of jailbreaks ... The window’s design prevents them from even determining where they are housed in the facility. Human interaction is minimal. Priso... […]
Drug-Drug Interactions of Common Cardiac Medications and Chemotherapeutic Agents
on February 18, 2019 at 12:51 pm
As the field of cardio-oncology evolves, the focus of treatment has shifted from reactive to proactive care. Prevention of cancer therapy-related cardiac dysfunction through optimization of cardiac ri... […]
3D protein structure reveals a new mechanism for future anti-cancer drugs
on February 17, 2019 at 2:37 pm
Olsen and his team use these protein structures to model interactions with other molecules, including potential new drugs. In the article, Olsen and his team report that they have discovered a new sit... […]
Customized drug alerts protect patients from medication errors, study finds
on February 15, 2019 at 3:01 pm
Researchers from Memphis, Tenn.-based St. Jude Children's Research Hospital used a comprehensive method to reduce drug interaction alerts clinicians receive, improving EHRs to lower alert fatigue and ... […]
Aryans Campus organises Seminar on ‘Drug Interaction & Medical Efficacy’
on February 15, 2019 at 1:38 pm
CHANDIGARH, Feb 15: Aryans College of Pharmacy, Rajpura, near Chandigarh organized a seminar on “Drug Interaction & Medical Efficacy” at its campus, here. Janvi Dureja, Assistant Professor, University ... […]
Researchers develop new method to customize and reduce drug interaction alerts
on February 13, 2019 at 11:14 pm
For anyone who regularly uses a computer, the experience of clicking through multipage user agreements is a shared frustration. Being bombarded with too much information can lead to people ignoring vi... […]
via Bing News