Interdisciplinary approach makes linking biological materials and electronic devices possible
One of the biggest challenges in cognitive or rehabilitation neurosciences is the ability to design a functional hybrid system that can connect and exchange information between biological systems, like neurons in the brain, and human-made electronic devices. A large multidisciplinary effort of researchers in Italy brought together physicists, chemists, biochemists, engineers, molecular biologists and physiologists to analyze the biocompatibility of the substrate used to connect these biological and human-made components, and investigate the functionality of the adhering cells, creating a living biohybrid system.
In an article appearing this week in AIP Advances, from AIP Publishing, the research team used the interaction between light and matter to investigate the material properties at the molecular level using Raman spectroscopy, a technique that, until now, has been principally applied to material science. Thanks to the coupling of the Raman spectrometer with a microscope, spectroscopy becomes a useful tool for investigating micro-objects such as cells and tissues. Raman spectroscopy presents clear advantages for this type of investigation: The molecular composition and the modi?cation of subcellular compartments can be obtained in label-free conditions with non-invasive methods and under physiological conditions, allowing the investigation of a large variety of biological processes both in vitro and in vivo.
Once the biocompatibility of the substrate was analyzed and the functionality of the adhering cells investigated, the next part of this puzzle is connecting with the electronic component. In this case a memristor was used.
“Its name reveals its peculiarity (MEMory ResISTOR), it has a sort of “memory”: depending on the amount of voltage that has been applied to it in the past, it is able to vary its resistance, because of a change of its microscopic physical properties,” said Silvia Caponi, a physicist at the Italian National Research Council in Rome. By combining memristors, it is possible to create pathways within the electrical circuits that work similar to the natural synapses, which develop variable weight in their connections to reproduce the adaptive/learning mechanism. Layers of organic polymers, like polyaniline (PANI) a semiconductor polymer, also have memristive properties, allowing them to work directly with biological materials into a hybrid bio-electronic system.
“We applied the analysis on a hybrid bio-inspired device but in a prospective view, this work provides the proof of concept of an integrated study able to analyse the status of living cells in a large variety of applications that merges nanosciences, neurosciences and bioelectronics,” said Caponi. A natural long-term objective of this work would be interfacing machines and nervous systems as seamlessly as possible.
The multidisciplinary team is ready to build on this proof of principle to realize the potential of memristor networks.
“Once assured the biocompatibility of the materials on which neurons grow,” said Caponi, “we want to define the materials and their functionalization procedures to find the best configuration for the neuron-memristor interface to deliver a full working hybrid bio-memristive system.”
Learn more: Researchers Create Living Bio-Hybrid System
The Latest on: Living biohybrid system
via Google News
The Latest on: Living biohybrid system
- Programmable nests for cellson January 17, 2020 at 8:09 am
the new nanocomposites can also be used for construction of programmable biohybrid systems. "Use of living microorganisms integrated within electrochemical devices is an expanding field of ...
- BioHybrid Solutions Awarded $30M Contract by the US Dept. of Defenseon December 3, 2019 at 4:00 pm
PITTSBURGH, Dec. 4, 2019 /PRNewswire/ -- BioHybrid Solutions ... BHS is leading the program in collaboration with FLIR Systems, Battelle, Ology Bioservices, the Allegheny Health Network, BTG ...
- Tiny ‘biohybrid’ robots directed by muscles and nerves built by researcherson September 17, 2019 at 1:32 pm
"The ability to drive muscle activity with neurons paves the way for further integration of neural units within biohybrid systems," Taher Saif, a mechanical science and engineering professor at ...
- Researchers build microscopic biohybrid robots propelled by muscles, nerveson September 16, 2019 at 12:03 pm
However, the team acknowledges that - like living organisms - no two biohybrid machines will develop ... Emergent Behavior for Integrated Cellular Systems and NSF's Emergent Frontiers in Research ...
- Modeling muscleon March 7, 2019 at 6:44 pm
Communication underlies the complexity of biological systems. Adaptive behaviors ranging from self-assembly to self-healing showcase the ability of such systems to sense and adapt to dynamic ...
- Japan’s ‘mad scientists’ pursue a cyborg-friendly futureon August 8, 2018 at 7:51 pm
Suspended in solution inside is a genuinely important breakthrough in biohybrid robotics – the emerging scientific field that seeks to combine living tissue with the metals and plastics normally ...
- Separate But Together: Ultrathin Membrane Both Isolates and Couples Living and Non-Living Catalystson June 25, 2018 at 5:00 pm
But, a fundamental challenge in designing biohybrid systems is that the environments that support optimal function of living cells and inorganic materials are chemically incompatible, resulting in ...
- Researchers integrate living muscles in roboton June 1, 2018 at 7:39 am
In a change of events, researchers have created a robotic device that contains living tissue inside it. Researchers from University of Tokyo have successfully created a new biohybrid robot ...
- Truly Cyborg Fingers Combine Robotics With Living Cellson May 30, 2018 at 12:24 pm
Biohybrid robotics is exactly as it sounds—an engineering technique that intertwines living, biological tissue ... contributing to the system’s longevity. A team led by Yuya Morimoto and ...
via Bing News