A team of mechanical engineers at the University of California San Diego has successfully used acoustic waves to move fluids through small channels at the nanoscale. The breakthrough is a first step toward the manufacturing of small, portable devices that could be used for drug discovery and microrobotics applications. The devices could be integrated in a lab on a chip to sort cells, move liquids, manipulate particles and sense other biological components. For example, it could be used to filter a wide range of particles, such as bacteria, to conduct rapid diagnosis.
The researchers detail their findings in the Nov. 14 issue of Advanced Functional Materials. This is the first time that surface acoustic waves have been used at the nanoscale.
The field of nanofluidics has long struggled with moving fluids within channels that are 1000 times smaller than the width of a hair, said James Friend, a professor and materials science expert at the Jacobs School of Engineering at UC San Diego. Current methods require bulky and expensive equipment as well as high temperatures. Moving fluid out of a channel that’s just a few nanometers high requires pressures of 1 megaPascal, or the equivalent of 10 atmospheres.
Researchers led by Friend had tried to use acoustic waves to move the fluids along at the nano scale for several years. They also wanted to do this with a device that could be manufactured at room temperature.
After a year of experimenting, post-doctoral researcher Morteza Miansari, now at Stanford, was able to build a device made of lithium niobate with nanoscale channels where fluids can be moved by surface acoustic waves. This was made possible by a new method Miansari developed to bond the material to itself at room temperature. The fabrication method can be easily scaled up, which would lower manufacturing costs. Building one device would cost $1000 but building 100,000 would drive the price down to $1 each.
The device is compatible with biological materials, cells and molecules.
Researchers used acoustic waves with a frequency of 20 megaHertz to manipulate fluids, droplets and particles in nanoslits that are 50 to 250 nanometers tall. To fill the channels, researchers applied the acoustic waves in the same direction as the fluid moving into the channels. To drain the channels, the sound waves were applied in the opposite direction.
By changing the height of the channels, the device could be used to filter a wide range of particles, down to large biomolecules such as siRNA, which would not fit in the slits. Essentially, the acoustic waves would drive fluids containing the particles into these channels. But while the fluid would go through, the particles would be left behind and form a dry mass. This could be used for rapid diagnosis in the field.
The Latest on: Nanofluidics
via Google News
The Latest on: Nanofluidics
- A microscopic physical description of electrothermal‐induced flow for control of ion current transport in microfluidics interfacing nanofluidicson March 24, 2019 at 5:00 pm
Abstract The phenomenon of electrothermal (ET) convection has recently captured great attention for transporting fluidic samples in microchannels embedding simple electrode structures. In the ...
- NanoMedical Systems Receives $3M Grant to Advance nStrada™ Implantable Nanofluidics System for Long-Term Treatment of Opioid Use Disorderon August 13, 2018 at 5:00 pm
August 14, 2018 08:00 ET | Source: NanoMedical Systems, Inc. AUSTIN, Texas, Aug. 14, 2018 (GLOBE NEWSWIRE) -- NanoMedical Systems, Inc. (NMS), an Austin-based company developing implantable, sustained ...
- Nanofluidics - recent progresson August 7, 2018 at 9:58 am
(Nanowerk Spotlight) Nanofluidics is the study and application of fluids in and around geometries with nanoscale characteristic dimensions. The field of nanofluidics is not brand-new. Some issues ...
- Computational Nanoscience: Energy Materials and Nanofluidics Sensors Designon May 21, 2018 at 5:00 pm
Recent advances in nanostructured materials have opened a wide range of new multifunctional materials with promising potential for the development of more efficient energy materials. Furthermore, the ...
- International School of Nanomedicine 3rd Course: “Nanofluidics, Nanoimaging and Nanomanipulation”on April 5, 2018 at 5:00 am
The course will provide many opportunities for interactions and discussions between students, postdocs, junior as well as senior investigators, encouraging and promoting networking between them. The ...
- Nanomushroom sensors: One material, many applicationson February 25, 2018 at 4:00 pm
In several recent papers, Prof. Shen and colleagues at the Micro/Bio/Nanofluidics Unit at the Okinawa Institute of Science and Technology (OIST), described their creation of a new biosensing material ...
- Combining nanofluidics and machine learning to diagnose canceron November 15, 2017 at 1:41 am
(Nanowerk News) Researchers have developed an approach for exosome isolation, wherein millions of nanofluidic exosome sorting components are incorporated onto a single chip and work in parallel to ...
- Nanofluidics research could contribute to oil spill cleanup strategieson January 4, 2017 at 5:38 am
The spreading of mixable liquids into 'droplet hats' was observed for the first time, which could lead to insight into improving strategies for cleaning animals affected by oil spills. When raindrops ...
- Two-dimensional nanofluidicson March 24, 2016 at 11:04 am
The remarkable electronic properties of graphene and related two-dimensional (2D) materials result from the confinement of electrons within the material. Similarly, the interstitial space between 2D ...
via Bing News