A drug originally used to boost the immune system is showing promise as a potential new treatment for lupus, joint Monash University and Peking University research published today shows. Lupus is an autoimmune disease, where the immune system attacks the body’s own organs and tissues.
An international team of scientists from Australia and China have, for the first time, shown in a study published in Nature Medicine, that a natural immune system protein called IL-2 can help restore balance to the overactive immune system of lupus patients. The drug could soon be rolled out for clinical trials in lupus treatment.
Monash Biomedicine Discovery Institute researcher, Dr Di Yu and Professor Zhanguo Li from Peking University People’s Hospital in China co-led the study.
Dr Yu said he hoped the drug could be approved as a lupus treatment within a handful of years.
“This drug, which can help the immune system fight against cancer, was approved in the 1990s but is not commonly used now. We’re now using this drug for a different purpose, based on our new knowledge of the immune system,” Dr Yu said.
“The amount we tested for treating lupus is much less than the dose used in treating cancers. We observed the treatment was safe and showed promising results, so there’s reason to believe formal trials could begin almost immediately,” he said.
Dr Yu said lupus could be a serious disease, and that it hadn’t been able to be treated in a very satisfactory way in the past.
IL-2 is a protein that regulates the activity of white blood cells, which are an important part of the immune system that protect the body against infections. In cancer therapy, patients are given large doses of IL-2 to stimulate their immune system but, paradoxically, the low dose IL-2 given to lupus sufferers in this study actually supressed the overactive part of their immune system that attacks their body. The research also showed the “self-checking” part of the immune system that prevents an overactive immune response, called regulatory T cells, increased after IL-2 treatment.
Professor Eric Morand, fellow Monash University researcher on the study and founder of the Asia Pacific Lupus Collaboration, said that in this study, IL-2 was given to people whose lupus wasn’t responding well to standard treatments.
“The real promise of this treatment is that it calms the hyperactive immune system through multiple mechanisms, which is very important as this new therapy may be effective for many patients,” Professor Morand said.
”As the drug has been on the market for some time for other diseases, it can be rapidly put into formal trials for lupus treatment right away.”
Learn more: Promising new treatment for lupus on the horizon
The Latest on: Lupus
via Google News
The Latest on: Lupus
- Systemic Lupus Erythematosus and Lupus Nephritis: Global Drug Forecast and Market Analysis to 2027on April 3, 2020 at 12:42 am
Reportlinker.com announces the release of the report "Systemic Lupus Erythematosus and Lupus Nephritis: Global Drug ...
- COVID-19 and Lupuson April 2, 2020 at 1:50 pm
Lupus raises your chances of catching any kind of infection. So if you have lupus, you may be more likely than other people to get COVID-19. And if you do, your symptoms are more likely to be serious.
- B-Cell Agent Shows Promise in Lupus Nephritison April 1, 2020 at 7:41 am
The novel immunomodulatory agent iguratimod, which interferes with B-cell differentiation, showed promise for refractory lupus nephritis in a small, preliminary study. Among 13 patients who had failed ...
- Correction officer with lupus fears for her health at Rikers Island amid COVID-19 pandmicon March 31, 2020 at 7:04 pm
Correction Officer June Jackson was diagnosed with lupus 18 years ago — two years after she started with the department of correction. Now she’s worried a deadly virus will put her in grave danger on ...
- Experimental coronavirus treatment causing chloroquine shortage for lupus, rheumatoid arthritis patientson March 31, 2020 at 2:05 pm
As the United States approaches 200,000 cases of coronavirus across the country, doctors fighting the virus still don't have a cure, or even a standard course of treatment. To that end, President ...
- Lupus patients face medication shortage as vital drug is used to treat coronaviruson March 30, 2020 at 9:24 pm
The FDA has given emergency approval for doctors to use anti-malaria drugs to treat the coronavirus. Now, millions of doses could be sent to hospitals across the country. One of those malaria ...
- NKF 2020: New Lupus Tx; Staying on Spironolactone, and Moreon March 30, 2020 at 2:30 pm
Novel Immunosuppressant for Lupus Nephritis Almost double the amount of people with active lupus nephritis saw a renal response when voclosporin treatment was added to mycophenolate and a low-dose ...
- ICU nurse with lupus is battling a need for own medicine and protective equipment amid coronavirus crisison March 30, 2020 at 12:56 pm
As a nurse with Lupus, Alicia Bligen is not only concerned about catching COVID-19, she's also worried about a shortage of hydroxychloroquine, a medicine she takes daily to function.
- Northeast Ohio coronavirus drug hoarding hurting lupus, arthritis patientson March 29, 2020 at 5:03 pm
The desperate search for drugs, which may help fight the coronavirus, is now causing a growing shortage of a drug that is crucial for patients suffering from lupus and arthritis.
- Demand for Lupus Drug Also Used to Treat COVID-19 Skyrocketson March 28, 2020 at 10:40 am
Now a San Diego, California woman who uses the medication to treat her lupus can’t get her prescription refilled. When Micaela Jimenez came to the pharmacy at the Kaiser Permanente in Rancho Bernardo, ...
via Bing News