A drug originally used to boost the immune system is showing promise as a potential new treatment for lupus, joint Monash University and Peking University research published today shows. Lupus is an autoimmune disease, where the immune system attacks the body’s own organs and tissues.
An international team of scientists from Australia and China have, for the first time, shown in a study published in Nature Medicine, that a natural immune system protein called IL-2 can help restore balance to the overactive immune system of lupus patients. The drug could soon be rolled out for clinical trials in lupus treatment.
Monash Biomedicine Discovery Institute researcher, Dr Di Yu and Professor Zhanguo Li from Peking University People’s Hospital in China co-led the study.
Dr Yu said he hoped the drug could be approved as a lupus treatment within a handful of years.
“This drug, which can help the immune system fight against cancer, was approved in the 1990s but is not commonly used now. We’re now using this drug for a different purpose, based on our new knowledge of the immune system,” Dr Yu said.
“The amount we tested for treating lupus is much less than the dose used in treating cancers. We observed the treatment was safe and showed promising results, so there’s reason to believe formal trials could begin almost immediately,” he said.
Dr Yu said lupus could be a serious disease, and that it hadn’t been able to be treated in a very satisfactory way in the past.
IL-2 is a protein that regulates the activity of white blood cells, which are an important part of the immune system that protect the body against infections. In cancer therapy, patients are given large doses of IL-2 to stimulate their immune system but, paradoxically, the low dose IL-2 given to lupus sufferers in this study actually supressed the overactive part of their immune system that attacks their body. The research also showed the “self-checking” part of the immune system that prevents an overactive immune response, called regulatory T cells, increased after IL-2 treatment.
Professor Eric Morand, fellow Monash University researcher on the study and founder of the Asia Pacific Lupus Collaboration, said that in this study, IL-2 was given to people whose lupus wasn’t responding well to standard treatments.
“The real promise of this treatment is that it calms the hyperactive immune system through multiple mechanisms, which is very important as this new therapy may be effective for many patients,” Professor Morand said.
”As the drug has been on the market for some time for other diseases, it can be rapidly put into formal trials for lupus treatment right away.”
Learn more: Promising new treatment for lupus on the horizon
The Latest on: Lupus
via Google News
The Latest on: Lupus
Altered Gut Microbiome Seen in Patients With Active Lupus
on February 20, 2019 at 10:11 am
WEDNESDAY, Feb. 20, 2019 (HealthDay News) -- The microbiome of patients with systemic lupus erythematosus (SLE), particularly those with increased disease activity, has reduced taxonomic complexity, a... […]
Study Finds Potential Link Between Abnormal Levels of Gut Bacteria and Lupus
on February 20, 2019 at 8:04 am
A new study investigated the potential link between systemic lupus erythematosus (SLE) and a specific bacteria in the gut. The researchers found that microorganisms or bacteria that live in the digest... […]
Imbalance in gut microbiome linked to Lupus
on February 20, 2019 at 7:22 am
Lupus, a chronic autoimmune disease is more common in women than men. Washington: According to a new study conducted by scientists at NYU School of Medicine, systemic lupus erythematosus (SLE) is link... […]
Gut Microbes May Help Drive Lupus, Study Finds
on February 20, 2019 at 6:00 am
WEDNESDAY, Feb. 20, 2019 (HealthDay News) -- An imbalance in the gut "microbiome" of people with lupus may be driving the chronic autoimmune disease as well as its flare-ups, new research suggests. Th... […]
Bacteria in the Gut May be a Cause of Lupus
on February 19, 2019 at 3:35 pm
NEW YORK, Feb. 19, 2019 /PRNewswire/ -- Pieces of bacteria that escape from the intestines may trigger lupus and associated disease flares in some patients, according to a new study partly funded by t... […]
Gut microbiome imbalances may help diagnose, track lupus
on February 19, 2019 at 2:38 pm
Feb. 19 (UPI) --Scientists have pinpointed gut bacteria that may cause painful flareups in people with Lupus, and this discovery that could lead to finding a better treatment for the condition, a new ... […]
How Gut Bacteria May Be Linked to Lupus
on February 19, 2019 at 1:58 pm
Women with lupus had higher amounts of a specific bacterium in their gut, along with increased levels of an antibody to that bacterium. Share on Pinterest Experts are learning how the gut microbiome a... […]
Lupus nephritis linked to severe gut microbiome imbalances
on February 19, 2019 at 1:17 pm
Patients with lupus demonstrate characteristic gut microbiome dysbiosis patterns, which appear to directly correspond to disease activity, according to data published in the Annals of the Rheumatic Di... […]
Imbalances in Gut Microbiome Strongly Linked to Lupus
on February 19, 2019 at 10:25 am
Systemic lupus erythematosus (SLE) is an autoimmune disease marked by the attack on joints, skin, and kidneys by the body's immune system. According to a new study, the condition is associated with an ... […]
Lupus can cause imbalances of bacteria in the gut
on February 19, 2019 at 7:32 am
According to a new study conducted by scientists at NYU School of Medicine, systemic lupus erythematosus (SLE) is linked to an abnormal mix of bacteria in the gut. The disease is marked by the attack ... […]
via Bing News