A drug originally used to boost the immune system is showing promise as a potential new treatment for lupus, joint Monash University and Peking University research published today shows. Lupus is an autoimmune disease, where the immune system attacks the body’s own organs and tissues.
An international team of scientists from Australia and China have, for the first time, shown in a study published in Nature Medicine, that a natural immune system protein called IL-2 can help restore balance to the overactive immune system of lupus patients. The drug could soon be rolled out for clinical trials in lupus treatment.
Monash Biomedicine Discovery Institute researcher, Dr Di Yu and Professor Zhanguo Li from Peking University People’s Hospital in China co-led the study.
Dr Yu said he hoped the drug could be approved as a lupus treatment within a handful of years.
“This drug, which can help the immune system fight against cancer, was approved in the 1990s but is not commonly used now. We’re now using this drug for a different purpose, based on our new knowledge of the immune system,” Dr Yu said.
“The amount we tested for treating lupus is much less than the dose used in treating cancers. We observed the treatment was safe and showed promising results, so there’s reason to believe formal trials could begin almost immediately,” he said.
Dr Yu said lupus could be a serious disease, and that it hadn’t been able to be treated in a very satisfactory way in the past.
IL-2 is a protein that regulates the activity of white blood cells, which are an important part of the immune system that protect the body against infections. In cancer therapy, patients are given large doses of IL-2 to stimulate their immune system but, paradoxically, the low dose IL-2 given to lupus sufferers in this study actually supressed the overactive part of their immune system that attacks their body. The research also showed the “self-checking” part of the immune system that prevents an overactive immune response, called regulatory T cells, increased after IL-2 treatment.
Professor Eric Morand, fellow Monash University researcher on the study and founder of the Asia Pacific Lupus Collaboration, said that in this study, IL-2 was given to people whose lupus wasn’t responding well to standard treatments.
“The real promise of this treatment is that it calms the hyperactive immune system through multiple mechanisms, which is very important as this new therapy may be effective for many patients,” Professor Morand said.
”As the drug has been on the market for some time for other diseases, it can be rapidly put into formal trials for lupus treatment right away.”
Learn more: Promising new treatment for lupus on the horizon
The Latest on: Lupus
via Google News
The Latest on: Lupus
- New study identifies gut-brain connection in development of Parkinson'son June 26, 2019 at 1:54 pm
Gut health is a major focus of many health studies of late. Some have found that certain bacteria in the gut can prevent food allergies in infants, while others have found that lupus, an autoimmune ... […]
- Roles of circular RNAs in immune regulation and autoimmune diseaseson June 26, 2019 at 10:40 am
Here, we focus on the roles of circRNAs in immune cells and immune regulation, highlighting their potential as biomarkers and biological functions in autoimmune diseases, such as systemic lupus ... […]
- Survey: Rheumatologists, dermatologists lack consensus on lupus managementon June 26, 2019 at 10:09 am
An online survey of dermatologists and rheumatologists managing patients with systemic lupus erythematosus revealed areas of consensus in laboratory studies and also some practice-based differences. ... […]
- New research provides insight into immunity of lupus patientson June 25, 2019 at 11:56 am
MANHASSET, N.Y., June 21, 2019 /PRNewswire/ -- The Feinstein Institutes for Medical Research Professor Betty Diamond, MD, has published findings in the July issue of Nature Immunology that provide ... […]
- Michael B. Jordan to Host Third Annual Lupus Awareness and Fundraising Eventon June 24, 2019 at 5:08 pm
The actor, whose mother is one of nearly 1 million people affected by the autoimmune disease across the U.S., will once again host MBJam, featuring games, activities and more on July 27 in Hollywood. ... […]
- Oklahoma scientists received $3.1 million grant to research cause of lupuson June 21, 2019 at 4:21 pm
OKLAHOMA CITY - Oklahoma Medical Research Foundation labs hold the key to very important research on lupus. "To see if we can figure out a mechanism or pathway that could eventually be targeted by ... […]
- People with Lupus Help Guide Development of the Lupus Foundation of America’s Disease Activity Measure – LFA-REALon June 20, 2019 at 6:02 am
Lupus can affect many different organs, and because of this people living with lupus experience a wide range of symptoms, and these symptoms can change through the course of the disease. That’s why ... […]
- 2019 Lupus Insight Prize Awarded to Dr. Ignacio Sanz: Recognizes Studies of Harmful Immune Cells in Lupuson June 19, 2019 at 8:03 pm
(MENAFN - Send2Press Newswire) BOSTON, Mass., June 19, 2019 (SEND2PRESS NEWSWIRE) — TheLupus Research Alliancehas awarded its 2019 Lupus Insight Prize to Ignacio Sanz, MD, for discovering that ... […]
- House of Representatives Approves $17.5 Million in Lupus-Specific Fundingon June 19, 2019 at 12:42 pm
Earlier today, the U.S. House of Representatives approved legislation that will provide $17.5 million in funding for lupus-specific research programs at the Centers for Disease Control and Prevention ... […]
- 90 Day Fiancé's Ashley Martson Hospitalized for Lupus Flare-Upon June 19, 2019 at 10:42 am
Ashley Martson has been admitted to the hospital following a lupus flare-up. "I am dealing with a lupus flare-up and pyelonephritis," the 90 Day Fiance star told E! News exclusively. "I also have a ... […]
via Bing News