Gene-editing technique to treat lung cancer is due to be tested in people in August
Chinese scientists are on the verge of being first in the world to inject people with cells modified using the CRISPR–Cas9 gene-editing technique.
A team led by Lu You, an oncologist at Sichuan University’s West China Hospital in Chengdu, plans to start testing such cells in people with lung cancer next month. The clinical trial received ethical approval from the hospital’s review board on July 6.
“It’s an exciting step forward,” says Carl June, a clinical researcher in immunotherapy at the University of Pennsylvania in Philadelphia.
There have been a number of human clinical trials using an alternative gene-editing technique, including one led by June, that have helped patients combat HIV. June is also a scientific adviser on a planned US trial that would also use CRISPR–Cas9-modified cells for the treatment of cancer.
Last month, an advisory panel of the US National Institutes of Health (NIH) approved that project. But the trial also requires a green light from the US Food and Drug Administration (FDA) and a university review board. The US researchers have said they could start their clinical trial by the end of this year.
The Chinese trial will enrol patients who have metastatic non-small cell lung cancer and for whom chemotherapy, radiation therapy and other treatments have failed. “Treatment options are very limited,” says Lu. “This technique is of great promise in bringing benefits to patients, especially the cancer patients whom we treat every day.”
The Latest on: CRISPR
via Google News
The Latest on: CRISPR
- COVID-19's impact Global CRISPR Cas9 Market 2020 Production, Revenue, Price and Gross Margin Analysis with Forecasts to 2025on November 26, 2020 at 12:42 pm
Global “CRISPR Cas9 market” competitive landscape provides particulars and data information by players. The report ...
- CRISPR gene editing of brain cells might prevent Alzheimer's diseaseon November 26, 2020 at 12:11 pm
CRISPR gene editing could be used to introduce a rare gene variant that greatly reduces the risk of Alzheimer's, but it has only been tried in a dish so far ...
- Research sheds new light on how the CRISPR immune system evolvedon November 25, 2020 at 6:11 pm
With new insights into how the genetic tool CRISPR - which allows direct editing of our genes - evolved and adapted, we are now one step closer to understanding the basis of the constant struggle for ...
- New insights into how the CRISPR immune system evolvedon November 25, 2020 at 9:50 am
With new insights into how the genetic tool CRISPR—which allows direct editing of our genes—evolved and adapted, we are now one step closer to understanding the basis of the constant struggle for ...
- Digital warm-start CRISPR assay enables sensitive quantitative detection of SARS-CoV-2 in clinical sampleson November 24, 2020 at 2:22 pm
In a recent medRxiv* preprint paper, researchers from the University of Connecticut Health Center in the United States unveil their digital warm-start CRISPR (WS-CRISPR) method for stringent and ...
- CRISPR-Based Therapy Shows Early Promise for Canceron November 23, 2020 at 1:56 pm
Researchers say they have used CRISPR, a new technology that allows scientists to edit a cell’s DNA, to destroy cancer cells in mice.
- Researchers tackle sickle cell disease with CRISPR-based gene editingon November 23, 2020 at 5:23 am
Scientists at ChristianaCare's Gene Editing Institute have received a $1 million grant from the Lisa Dean Moseley Foundation to develop a novel gene therapy for inherited blood disorders including ...
- CRISPR-Based Gene Editing Approach Destroys Cancer Cells, Boost Survival From Some Cancers By 80 Percenton November 23, 2020 at 5:06 am
A revolutionary CRISPR-based gene therapy has shown impressive results in cell and mouse models, according to a study published in Science Advances. After ...
- Novel CRISPR system can stop cancer in its trackson November 21, 2020 at 12:40 pm
Scientists have developed a new system using the CRISPR genome-editing system to attack and kill cancer cells. The system targets cancel cells directly and, like “scissors,” cuts their ...
- Is Gene Editing Already Leaving CRISPR Therapeutics Behind?on November 21, 2020 at 8:33 am
Innovative companies are trying to ensure that CRISPR Therapeutics' foothold in gene editing doesn't last forever.
via Bing News