Lychnopholide, a substance isolated from a Brazilian plant, and formulated as part of “nanocapsules” cured more than half of a group of mice that had been infected experimentally with Chagas disease parasites.
“Chagas disease affects millions of people, mainly in poor rural areas of 21 Latin American countries,” said Marta de Lana, PhD. The research is published in online ahead of print June 20 in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology.
The new nanocapsules that constitute the delivery system for the lychnopholide in this study are a clever advance over the previous version. The previous–conventional–nanocapsules are recognized as foreign and attacked by host immune cells as they travel through the blood, before entering host cells, where the parasites lodge, said de Lana, who is Professor of Clinical Parasitology, in the School of Pharmacy, the Federal University of Ouro Preto, Minas Gerais, Brazil.
The new “stealth” nanocapsules are designed to go unrecognized by immune cells that patrol the blood. Once they enter host cells, they release the lychnopholide, killing the parasites,Trypanosome cruzi.
Another advantage of the stealth nanocapsules is that they can be taken orally, rather than intravenously, as they are impervious to the acidity and enzymes of the stomach. This is far more practical, especially in less developed countries.
Not surprisingly, the stealth nanocapsules are considerably more effective than the conventional nanocapsules. In the study, in the acute (early) phase of the disease, the stealth nanocapsules cured 62.5 percent of the mice, compared to 57.0 percent for the conventional nanocapsules. During the later chronic phase, the stealth and the conventional nanocapsules cured 55.6 percent and 30.0 percent of the mice, respectively.
“Both nanoencapsulated formulations are so simple that they may be produced in a simple laboratory,” said de Lana. Additionally, scale-up for commercial production would be simple, she said.
An estimated seven million people, mostly in Latin America, have Chagas disease, according to the World Health Organization. Up to one third develop cardiac abnormalities including enlarged heart, and arrhythmias, which can cause sudden death. As many as ten percent develop neurological and/or digestive problems. The main mechanism of spread is via triatomine insects, vectors that are known colloquially as kissing bugs, assassin bugs, or vampire bugs. Recently, the disease has spread to the United States and to several countries on other continents via other mechanisms.
No vaccines are available for Chagas. Treatment with conventional drugs–benznidazole or nifurtimox–is very effective at eradicating the parasites early in the disease’ acute phase. But efficacy falls off sharply with time. This is a problem because symptoms often take time to develop, and by the time they appear, the disease may be too far along to be cured using these drugs. Additionally, both drugs have harmful side effects.
The Latest on: Chagas disease
via Google News
The Latest on: Chagas disease
- Suresh Garimella: Squandering the potential of millions of young peopleon June 26, 2020 at 4:03 pm
Our failure to nurture students from underrepresented groups who have a talent for science and technology will make America weaker.
- We're Squandering the Potential of Millions of Young Peopleon June 22, 2020 at 4:08 am
Our failure to nurture students from underrepresented groups with a talent for science and technology will make America weaker ...
- Chagas Disease Threat: Better Diagnostics Sought, U.S. Department of Defense Gets Involvedon June 19, 2020 at 3:00 am
Healthcare publisher, Kalorama Information, highlights an opportunity for test makers from its Emerging Infectious Testing report. ARLINGTON, Va. (PRWEB) Per ...
- Chagas Disease Treatment Marketon June 12, 2020 at 12:55 am
According to a new report published by Allied Market Research, titled, "Chagas Disease Treatment Market by Treatment Type (Antiparasitic Treatment, and Symptomatic Treatment), Drug Type ...
- Kissing bugs also find suitable climatic conditions in Europeon June 11, 2020 at 5:50 am
Chagas disease, caused by a parasite, has spread outside of Latin America and carries a high risk of heart disease Aug 20, 2018 Scientists identify new hosts for Chagas disease vectors ...
- Development and Validation of a Risk Score for Predicting Death in Chagas' Heart Diseaseon June 10, 2020 at 5:00 pm
Chagas' disease is an important health problem in Latin America, and cardiac involvement is associated with substantial morbidity and mortality. We developed a model to predict the risk of death ...
- Kissing bugs also find suitable climatic conditions in Europeon June 10, 2020 at 9:40 am
An infection with Chagas disease is only possible in Latin America since the insect species that spread the disease only occur there. Scientists at Goethe University and the Senckenberg Society ...
- Kissing bugs also find suitable climatic conditions in Europeon June 9, 2020 at 5:00 pm
The acute phase of the tropical Chagas disease (American Trypanosomiasis) is usually symptom-free: only in every third case does the infecting parasite (Trypanosoma cruzi) cause any symptoms at ...
- Chagas Disease Surveillance Activities — Seven States, 2017on June 8, 2020 at 5:00 pm
Morbidity and Mortality Weekly Report. 2018;67(26):738-741. The findings in this report are subject to at least one limitation. The data used for this report might have been subject to recall bias ...
- Chagas Disease News and Researchon June 3, 2020 at 5:00 pm
Sleeping sickness and Chagas disease, caused by the tropical parasites Trypanosoma brucei and Trypanosoma cruzi, constitute a significant socioeconomic burden in low-income countries of sub ...
via Bing News