Scientists in Japan have designed new molecules that modify the circadian rhythm, opening the way to the possibility of managing jet lag and improving treatments for sleep disorders.
The negative impacts of jet lag and shift work could be significantly reduced if it were possible to reset our 24-hour natural circadian or sleep/wake cycle. Researchers at Nagoya University’s Institute of Transformative Bio-Molecules (ITbM) have taken the first step in that direction by synthesising molecules that can shorten the circadian period. These molecules act directly on one of our “clock proteins”, called CRY.
Most living organisms, including humans, have a biological clock that resets every 24 hours, regulating functions such as sleep/wake cycles and metabolism. When this cycle is disrupted, like in jet lag, sleep disorders ensue. Long-term sleep loss may affect the cardiovascular, endocrine, immune and nervous systems with severe consequences including hypertension, obesity and mental health disorders, among others.
Our biological clock is basically run by four “master regulator” proteins that work in tandem. CLOCK and BMAL1, when combined, promote the production of the proteins PER and CRY. These proteins, in turn, block CLOCK and BMAL1, thus closing the cycle. This cycle of activation, production and stop/block goes around once a day and is also influenced by a compound called FBXL3, which flags CRY for degradation by cellular enzymes.
A molecule discovered in 2012, called KL001, lengthens the circadian cycle by competing with FBLX3 for the same spot on the CRY protein, preventing its degradation. By carefully analysing its structure, the ITbM researchers prepared compounds that were similar to KL001, thus synthesising the first circadian shortening molecules that target the CRY protein.
This tailor-made approach to designing molecules holds great potential for the future. Takashi Yoshimura, one of the authors of the article, says, “We hope we can make further use of synthetic chemistry to make bioactive molecules that can control the circadian rhythm of animals and gain further insight into the circadian clock mechanism, which will surely contribute to medical applications, food production and advances in clock research.”
The Latest on: Circadian rhythm
via Google News
The Latest on: Circadian rhythm
- Jesus Loves Electro: The Norwegian EDM duo with 10 years of ministryon October 19, 2019 at 1:42 am
Jesus Loves Electro will soon clock up an amazing 10 years of music making and their Cross Rhythms radio hits "Burning Love" and "Life (Radio Edit)" show the JLE duo - Casper Cornelius and Ole Jose - ...
- 14th Annual Latin American Cultural Week Set for November 9 Through 19on October 18, 2019 at 12:20 pm
Manhattan - Suggested Donation $10 Multi-Grammy Award Pianist/Composer Baden Goyo presents an original musical journey that blends the tradition of Afro-Venezuelan rhythms with the colors of jazz ...
- CT Poets Corner: West Hartford poet Maria Sassi inspired by the rhythms of lifeon October 17, 2019 at 3:07 am
“Poetry is the art of depicting in words all rhythms of life,” says Maria Sassi, a prize-winning poet and playwright and the first poet laureate of West Hartford. The words in her own poems flow in ...
- Yao Lee, singer known as the ‘Silver Voice’ who fused Chinese folk forms with jazz rhythms – obituaryon October 14, 2019 at 1:44 pm
Yao Lee, also known as Yao Li, who has died aged 96, was a singer known as the “Silver Voice”, one of the “Seven Great Singing Stars of Shanghai”; hugely prolific, with a soft, lilting delivery, she ...
- Tossing and Catching Rhythms on Stages and City Streetson October 14, 2019 at 10:26 am
One day about 10 years ago, the dancer Jermone Donte Beacham received a message from a stranger on YouTube. He ignored it, but the stranger kept trying to contact him. Finally he decided to write back ...
- Rhythms of Manipur wows audience at Tirumala, Andhra Pradeshon October 12, 2019 at 5:19 pm
Imphal, October 12 2019: Artistes of the Rhythms of Manipur captivated audience with their performances at the Srivari Salakatla Brahmotsavams 2019, Andhra Pradesh. An eleven member troupe of the ...
- 20 Years Later: Mos Def’s ‘Black on Both Sides’ Captures the Rhythms of Black Expressionon October 12, 2019 at 7:34 am
Both lyrically and musically, the album remains a grand display of Black expression in its purest form by being unafraid to tap into the culture’s many rhythms. Mos Def is the reason I fell in ...
- Rhythms of the night take overon October 11, 2019 at 6:53 pm
Tel: 03-6201 0318 Backyard has been kicking out the jams for over two decades and shows no signs of slowing down. Monday nights are usually pretty low-key but there is definitely more in store as the ...
- Sleep and synaptic rhythmson October 11, 2019 at 5:03 am
This characteristic phosphorylation pattern seems to reflect buildup and dissipation of sleep and wake pressure since sleep deprivation almost completely abolished synaptic phosphorylation rhythms.
- Dance review: Tempo Dance Festival keeps indigenous rhythms aliveon October 10, 2019 at 9:19 am
A joyous celebration of Samoan cultural traditions featured in week two of this year's Tempo Dance Festival when Fa'asinomaga/Identity took over Q Theatre's main auditorium with an effervescent, ...
via Bing News