Man-made blood vessels developed by researchers at Duke University, Yale University and the tissue engineering company Humacyte appear to be both safe and more durable than commonly used synthetic versions in patients undergoing kidney dialysis, the researchers report.
The findings, published May 12 in The Lancet, resulted from a phase 2 study among 60 patients with kidney failure who required dialysis, which often requires a synthetic graft when the patient’s own blood vessel degrades from frequent needle sticks.
Such grafts, however, are prone to infection, clotting, and other complications. And alternative bioengineered grafts derived from the patient, a donor, or animal tissue have been shown to perform no better than synthetics.
The Duke and Yale research team — along with surgeons in Poland and the United States and scientists at Humacyte, which is developing the bioengineered vessel — tested a human acellular vessel, or HAV, that is manufactured to be available to patients on demand, rather than made-to-order using an individual’s own cells.
“The bioengineered blood vessel represents a critical step in tissue engineering,” said Jeffrey Lawson, M.D., Ph.D., professor of surgery and pathology at Duke and chief medical officer of Humacyte. “Because these vessels contain no living cells, patients have access to off-the-shelf engineered grafts that can be used without any waiting period associated with tailor-made products.”
Lawson and co-author Laura Niklason, M.D., Ph.D., professor of anesthesiology and biomedical engineering at Yale, are principals of Humacyte, Inc., which supported the clinical trial.
To create the vessels, the researchers first isolated vascular cells from human donors and grew them in tissue culture. They then placed the cells on a degradable scaffold shaped like a blood vessel. As the tissue grew, it was bathed in nutrients and stretched to acquire the physical properties of real blood vessels.
“After that process, which takes eight weeks, the scaffold degrades and what we have left is engineered tissue that we have grown from scratch,” Niklason said.
The final step was to wash away the cells with a special solution. The remaining “de-cellularized” tissue retains the structure of the vessel but none of the components that would cause tissue rejection.
One year after implantation, the bioengineered vessels appeared to be both safe and functional, maintaining their mechanical integrity, the researchers report. The patients also showed no sign of rejection.
While there were cases of adverse events such as clotting, the rates of those events were comparable to other dialysis grafts. Notably, the durability of the bioengineered vessels at one year was 89 percent, compared to the approximately 60-percent rate of synthetic grafts reported in previous studies.
Additionally, the researchers noted that after implantation, the bioengineered vessels had been repopulated with the patient’s own cells, so nonliving tissue became living over time.
“The fact that an implanted acellular tube becomes a living human tissue has implications for regenerative medicine in a very profound way,” Lawson said.
The Latest on: Bioengineered Blood Vessel
via Google News
The Latest on: Bioengineered Blood Vessel
- Latest tech in clinical grafts? A ‘universal’ blood vesselon January 16, 2020 at 12:26 pm
Yale doctors have developed a way to create vascular grafts from stem cells that are as strong as the original blood vessels they would replace. The advance, demonstrated in an animal model, may lead ...
- Bioengineered skin might be a reality somedayon December 21, 2019 at 12:00 pm
People who need skin grafts because of burns or other injuries might someday get lab-grown, bioengineered skin that works much like real human skin, Swiss researchers report. This new skin not ...
- Bioengineered Blood Vessels Can Grow Inside Animalson September 26, 2019 at 5:00 pm
Artificial blood vessels transplanted into three lambs ... which carries blood from the heart to the lungs. If these bioengineered arteries work in humans, they could spare children with heart ...
- Engineered vessels evolve into living tissueon March 28, 2019 at 4:04 am
(Nanowerk News) In one of the longest follow-up studies of its kind, researchers found that their specially bioengineered blood vessels evolved into living tissue after human implantation. Researchers ...
- Bio Roundup: DIY Biohacking, PCSK9 Data, Solid Setback & Moreon March 15, 2019 at 5:00 pm
Humacyte closed a $75 million Series C round that the Research Triangle Park, NC, company will use to continue Phase 3 studies of its bioengineered blood vessels and to complete a bioprocessing ...
- FMC takes stake in Humacyte in bet on bioengineered blood vesselon June 11, 2018 at 6:24 am
FMC will take a 19 percent stake in the privately held company. Humacyte's bioengineered blood vessels are currently being tested in the last of three phases that are typically required for market ...
- Bioengineered gel helps repair brain tissueon May 22, 2018 at 5:00 pm
Researchers at the University of California, Los Angeles, have now developed a bioengineered angiogenic gel that promotes new brain tissue growth as well as the formation of axonal networks along ...
- Biogel Promotes Brain Tissue Growth and Limb Recovery after Stroke in Miceon May 22, 2018 at 6:49 am
U.S. scientists have developed a bioengineered gel that can promote the growth of new blood vessels and neurons in stroke-damaged mice, resulting in what researchers call “dramatic ...
- Bioengineered blood vessel is safe for dialysis patients, study findson May 13, 2016 at 10:31 am
Scientists have created bioengineered blood vessels for kidney-disease patients on dialysis. The human-made vessels appeared to be both safe and more durable than commonly used synthetic versions ...
- Bioengineered blood vessel is safe for dialysis patients, study findson May 13, 2016 at 7:26 am
New Haven, Conn.--A Yale scientist collaborated with researchers at Duke University and surgeons in Poland and the United States to create bioengineered blood vessels for kidney-disease patients ...
via Bing News