Melbourne researchers have uncovered genes responsible for the way the body fights infection at the point of ‘invasion’ – whether it’s the skin, liver, lungs or the gut.
Research led by Dr Axel Kallies and Dr Klaas van Gisbergen at the Walter and Eliza Hall Institute of Medical Research, and Dr Laura Mackay from the University of Melbourne at the Peter Doherty Institute for Infection and Immunity has identified the genes Hobit and Blimp1 and found that they control a universal molecular program responsible for placing immune cells at the ‘front lines’ of the body to fight infection and cancer.
The presence of these organ-residing cells, which differ strikingly from their counterparts circulating in the blood stream, is key to local protection against viruses and bacteria.
Walter and Eliza Hall Institute’s Dr Kallies said the human body was fighting disease-causing pathogens every minute of its life. Dr Kallies said identifying how immune cells remain in the part of the body where they are needed most was critical to developing better ways to protect us from infections such as malaria or HIV.
“Discovering these ‘local heroes’ and knowing how the localised immune response is established allows us to find ways to ensure the required cells are positioned where they are needed most,” Dr Kallies said.
“This research will help us understand how immune cells adapt, survive and respond within the organs they protect. This is critical to rid the body of pathogens even before they are established and may also have implications for understanding how the spread of cancer could be prevented.”
The Doherty Institute’s Dr Laura Mackay, who is also an associate investigator with the Australian Research Council Centre of Excellence in Advanced Molecular Imaging, said the factors that control the ‘tissue-residency’ of immune cells – their ability to locally reside in different organs of the body – was previously unknown.
“These results have major implications for developing strategies to induce immune cells in tissues that protect against infectious diseases,” Dr Mackay said.
“It’s a crucial discovery for future vaccine strategies – Hobit and Blimp1 would be key to placing immune cells in the tissues, which we know are really important for protection.”
The Latest on: Localised immune response
via Google News
The Latest on: Localised immune response
- Moderna Reports Second Quarter 2020 Financial Results and Provides Business Updateson August 5, 2020 at 5:26 am
Cancer Vaccines:These programs focus on stimulating a patient’s immune system with antigens derived from tumor-specific mutations to enable the immune system to elicit a more effective anti-tumor ...
- Inflammation and your health: what's all the fuss?on August 4, 2020 at 6:13 am
Chances are you've heard people talking about inflammation recently. But, unlike other health trends or so-called buzzwords, there's a good reason why it's on everyone's mind. On one hand, ...
- Prospective Study Finds Potential Utility of MeMed's Host Immune Technology for Personalizing Treatment of Severe COVID-19 Patientson August 3, 2020 at 5:41 am
Prospective Study Finds Potential Utility of MeMed's Host Immune Technology for Personalizing Treatment of Severe COVID-19 Patients Rapid and Continuous Measurement of the Host-Immune Response with ...
- Bolsonaro tests positive for coronavirus again: Live updateson July 30, 2020 at 12:17 am
India joins many other countries and cities across the globe in reimposing localised lockdowns following ... country had worked to boost patients' immune systems and is set for final testing.
- Checkpoint Therapeutics to Present Cosibelimab Interim Results from Registration-Enabling Trial at ESMO Virtual Congress 2020on July 27, 2020 at 9:08 am
While most cases are localized tumors amenable to curative ... 99% target tumor occupancy to reactivate an antitumor immune response and the additional benefit of a functional Fc domain capable ...
- Non-specific body defenceson July 25, 2020 at 9:11 pm
The inflammatory response is a localised defence mechanism used by the body following a physical injury or infection. In response to injury and infection, specialised immune cells called mast ...
- Expression of inhibitory receptors by B cells in chronic human infectious diseases restricts responses to membrane-associated antigenson July 24, 2020 at 11:36 am
Chronic human infectious diseases, including malaria, are associated with a large expansion of a phenotypically and transcriptionally distinct subpopulation of B cells distinguished by their high ...
- Prospective Study Finds Potential Utility of MeMed's Host Immune Technology for Personalizing Treatment of Severe COVID-19 Patientson July 23, 2020 at 3:30 am
"In the majority of COVID-19 positive patients, the host mounts a localized immune response sufficient to clear the virus from the upper airways and possibly the lungs, following which the immune ...
- Faulty immune response to SARS-CoV-2 one of the main causes of deathon July 6, 2020 at 10:44 pm
This shows that immune responses largely determine ... Thus, viral infection in COVID-19 does not cause localized inflammatory responses. This is true of the presence of the virus in the lung ...
via Bing News