The discovery has broad ranging applications in stopping viral outbreaks such as hepatitis C in humans and a number of viruses in plants and animals
Viruses are molecular thieves that take from their hosts under the cloak of darkness. But now a Virginia Tech scientist has found a way to not only track viral hijackers, but also potentially stop them from replicating.
The discovery has broad ranging applications in stopping viral outbreaks such as Hepatitis C in humans and a number of viruses in plants and animals because it applies to many viruses in the largest category of viral classes — positive-strand RNA viruses.
The findings were recently published in the Proceedings of the National Academy of Sciences.
“Even though these viruses infect very different hosts, they all replicate similarly across the board, so what we learn from one virus can potentially be translated to control viruses in agricultural production as well as human health,” said Xiaofeng Wang, an assistant professor of plant pathology, physiology, and weed science in the College of Agriculture and Life Sciences.
Wang’s findings could target any number of plant viruses. One virus Wang has studied — the cucumber mosaic virus — affects pumpkin, squash and gourds in 1,200 species in over 100 plant families.
Sprays could be developed to halt the virus on plants, saving millions of dollars in agricultural sectors.
Wang, who is a Fralin Life Science-associated faculty member, used brome mosaic virus to study how viral infections start. He found that the brome mosaic virus stimulates synthesis of host lipid cells called phosphatidylcholine at the sites where viral replication occurs, and that by inhibiting its synthesis, the viral replication stopped.
Wang also collaborated with researchers to study how human viruses like Hepatitis C virus and poliovirus regulate host lipid synthesis and found that viral replication behaved in the same way as using plant viruses. The ramifications for human health mean that developing a drug delivery system to combat the Hepatitis C virus would be much more nimble in treating viral outbreaks than slow-moving vaccines, and could play a crucial role in halting the debilitating infection which affects 3.5 million people in the U.S. according to the Centers for Disease Control.
Viruses can’t replicate by themselves. They are essentially thieves that break into cells and multiply by hijacking the machinery of the host cells and proliferating and remodeling lipid-containing membranes such as phosphatidylcholine — one the most prominent lipids in host membranes. Wang and his collaborators were able to see where exactly the virus replications started and how they managed their hosts to meet their needs. Based on the finding of Wang and his collaborators, new ways can be developed to stop phosphatidylcholine synthesis for viral replication, but leave the host undamaged.
“The better we understand the mechanisms of a biological process, be it virus replication or cell division, the better are our options to rationally design tools that can control it,” said George Belov, a collaborator of Wang’s and an assistant professor of virology at the University of Maryland. “In the case of viral replication it may provide us with novel ways to control infection without causing host toxicity and a generation of viral-resistant mutants.”
The Latest on: Stopping virus replication
The Latest on: Biomechanics
via Google News
The Latest on: Stopping virus replication
- Another Piece of Ebola Virus Puzzle Identifiedon October 3, 2019 at 5:00 pm
Scientists around the globe are trying to pinpoint potential drug targets to stop Ebola virus disease ... this new work as a "turning point for understanding how replication of Ebola virus is ...
- Arbutus Announces Decision to Discontinue Development of AB-506, an Oral Capsid Inhibitor for the Treatment of Chronic Hepatitis Bon October 3, 2019 at 1:06 pm
HBV core protein assembles into a capsid structure, which is required for viral replication. The current standard-of-care therapy for HBV, primarily nucleoside analogues that work by stopping the ...
- Study identifies virulence markers in hard-to-eliminate viruson September 24, 2019 at 5:00 pm
Marek's disease can be deadly to unvaccinated poultry. Vaccination prevents life-threatening tumors, but it doesn't stop virus replication, the article states. The virus's persistence in poultry may ...
- Stopping cold viruses dead by blocking replicationon September 16, 2019 at 10:00 pm
scientists reported a potentially successful new approach to stop cold viruses from replicating inside human cells – by blocking the formation of a protein that is vital to this process. This ...
- In human cells and mice, a cure for the common cold, Stanford-UCSF study reportson September 15, 2019 at 5:00 pm
Disabling a single, apparently noncritical protein in cells may foil replication of the viruses that cause half ... The approach of targeting proteins in our own cells also worked to stop viruses ...
- Does hepatitis C virus remain in the body after successful treatment?on September 8, 2019 at 10:49 pm
Stopping viral replication stops inflammation in the liver and permits ... Although DNA is the primary genetic material of cells, RNA is the genetic material for some viruses like HIV. Any blood cell ...
- Following three failed replications of 2016 study, Science maintains 'EEoC'on September 5, 2019 at 11:23 am
"Two of the replication attempts (Di Mascio et al. and Iwamoto et al.) used the same SIVmac239-nef-stop virus as in Byrareddy et al. but did not replicate the sustained low viral load, a result ...
- Incomplete influenza A virus genomes occur frequently but are readily complemented during localized viral spreadon August 6, 2019 at 2:10 am
The potential for complementation of IVGs in vivo was furthermore evidenced by the replication in guinea pigs of Pan/99-M.STOP virus, which requires coinfection for productive infection. Importantly, ...
- Snapshots of the flu virus replication machine in actionon June 4, 2019 at 5:32 am
As the viral polymerase is essential for the replication of the flu virus, it is a prime target for the development ... The advantage of drugs that stop the polymerase functioning is that it is much ...
- Potential therapy for dengue, Japanese encephalitison December 16, 2018 at 4:00 pm
They have shown that an inhibitor molecule can stop viral replication by disrupting the molecular pathway inside the host cells – a finding that could lead to potential therapies for dengue and JE. It ...
via Bing News