Vanderbilt University Medical Center nephrologist and Associate Professor of Medicine Dr. William H. Fissell IV, is making major progress on a first-of-its kind device to free kidney patients from dialysis. He is building an implantable artificial kidney with microchip filters and living kidney cells that will be powered by a patient’s own heart.
“We are creating a bio-hybrid device that can mimic a kidney to remove enough waste products, salt and water to keep a patient off dialysis,” said Fissell.
Fissell says the goal is to make it small enough, roughly the size of a soda can, to be implanted inside a patient’s body.
The key to the device is a microchip.
“It’s called silicon nanotechnology. It uses the same processes that were developed by the microelectronics industry for computers,” said Fissell.
The chips are affordable, precise and make ideal filters. Fissell and his team are designing each pore in the filter one by one based on what they want that pore to do. Each device will hold roughly fifteen microchips layered on top of each other.
But the microchips have another essential role beyond filtering.
“They’re also the scaffold in which living kidney cells will rest,” said Fissell.
Fissell and his team use live kidney cells that will grow on and around the microchip filters. The goal is for these cells to mimic the natural actions of the kidney.
“We can leverage Mother Nature’s 60 million years of research and development and use kidney cells that fortunately for us grow well in the lab dish, and grow them into a bioreactor of living cells that will be the only ‘Santa Claus’ membrane in the world: the only membrane that will know which chemicals have been naughty and which have been nice. Then they can reabsorb the nutrients your body needs and discard the wastes your body desperately wants to get rid of,” said Fissell.
Because this bio-hybrid device sits out of reach from the body’s immune response, it is protected from rejection.
“The issue is not one of immune compliance, of matching, like it is with an organ transplant,” said Fissell.
The device operates naturally with a patient’s blood flow.
“Our challenge is to take blood in a blood vessel and push it through the device. We must transform that unsteady pulsating blood flow in the arteries and move it through an artificial device without clotting or damage.”
And that’s where Vanderbilt biomedical engineer Amanda Buck comes in. Buck is using fluid dynamics to see if there are certain regions in the device that might cause clotting.
“It’s fun to go in and work in a field that I love, fluid mechanics, and get to see it help somebody,” said Buck.
Vanderbilt biomedical engineer Amanda Buck is using fluid dynamics to see if there are certain regions in the device that might cause clotting.
Fissell says he has a long list of dialysis patients eager to join a future human trial. Pilot studies of the silicon filters could start in patients by the end of 2017.
The Latest on: Artificial Kidney
via Google News
The Latest on: Artificial Kidney
- VA’s Nat’l AI Institute Seeks Partnerships for Rapid R&D Effortson January 23, 2020 at 2:24 pm
The Department of Veterans Affairs’ National Artificial Intelligence Institute is working with ... firm DeepMind Health to create an AI-driven forecasting system for kidney disease. According to ...
- U of T researchers develop method to improve transplantation of artificial insulin-producing cellson January 22, 2020 at 9:25 am
But this function is severely dampened in those living with diabetes, where significantly lower insulin production can, if untreated, lead to blindness or kidney failure. Recent advances have enabled ...
- Hemodialysis Equipment Market to Rise at an Impressive 4.5% CAGR | USD 16,321.6 Mn by 2026on January 22, 2020 at 2:39 am
... than 1 lakh patients are awaiting kidney transplants in the U.S. This shortage for kidney transplants act as a potential growth trigger in the market. This shows that the market scope is likely to ...
- Artificial Organs Bionics Market 2016-2022 / Trends, Share, Size and Forecast Reporton January 21, 2020 at 4:35 am
The Global artificial organs bionics market was valued at US$ 18.5 Billion in 2017 and is expected to reach US$ 29.12 Billion by 2022 growing at a CAGR of9.5% during the forecast period 2017-2022.
- Singaporean start-up’s portable ‘kidney’ could shrink dialysis machines, giving patients their freedom backon January 20, 2020 at 12:45 pm
“Maybe I would be able to travel more.” But a Singaporean company is offering new hope with its work on a portable artificial kidney weighing just 2 to 3 kilograms, as advances in technology begin to ...
- Veterinarians to cat owners: your cat will or will not develop chronic kidney disease within two yearson January 20, 2020 at 3:00 am
RenalTech's predictive diagnostic information has created more than 100,000 opportunities for pet owners to seek proactive, early care for cats with a positive RenalTech status ORLANDO, Fla., Jan. 20, ...
- Early Recognition of Burn- and Trauma-Related Acute Kidney Injury: A Pilot Comparison of Machine Learning Techniqueson January 14, 2020 at 2:12 am
Severely burned and non-burned trauma patients are at risk for acute kidney injury (AKI). The study objective was to assess the theoretical performance of artificial intelligence (AI)/machine learning ...
- Kidney disease is on the rise in Minnesotaon January 10, 2020 at 12:59 pm
The order sets goals of reducing kidney disease by 25 percent in the next decade, increase at-home dialysis, double the number of kidneys available for transplants and encourage development of an ...
- Wearable Artificial Kidney Market Predicted to Rise at a Lucrative CAGR by 2024on January 5, 2020 at 4:00 pm
Zion Market Research analysts forecasts the latest report on "Global Wearable Artificial Kidney Market Set for Rapid Growth, to reach Value around USD 10.7 Billion by 2025” , according to their ...
- New artificial kidney brings hope/mobility to dialysis patientson December 30, 2019 at 2:48 am
In news that could bring hope and some relief to people going through the struggle of kidney failure, researchers have come up with an artificial kidney that can be worn; eliminating some of the ...
via Bing News