Frequent measurement of blood flow changes could improve the ability of health care providers to diagnose and treat patients with vascular conditions, such as those associated with diabetes and high blood pressure.
A U.S.-Chinese team that included researchers from the National Institute of Biomedical Imaging and Bioengineering(NIBIB) and the National Heart, Lung, and Blood Institute, both parts of the National Institutes of Health, conducted a pilot study showing that an ultrathin, skin-conforming sensor—resembling a peel-away tattoo—provides non-invasive, precise, and continuous monitoring of circulation, including blood flow within the smallest vessels.
In a study published in the Oct. 30, 2015 issue of Science Advances, the researchers showed that the sensor can measure blood flow in both large and micro-sized blood vessels near the skin’s surface. They also provided details about the design and operation of the device. The researchers assessed the sensor’s performance under various conditions, showing that the technology could be used for continuous blood-flow monitoring during daily activities and in a variety of clinical research and health care settings.
In addition to diabetes and chronic hypertension, conditions that affect the health of blood vessels and surrounding tissue include kidney disease, autoimmune and other inflammatory conditions, the effects of aging and smoking, and a class of cholesterol-related abnormalities called dyslipidemias. Continuous monitoring of variations in blood flow could also be valuable in assessing these conditions in clinical and research scenarios.
The pilot-tested device, which was co-developed with researchers at Northwestern University, is among a variety of tools available to measure blood flow. Other devices, such as ones based on optical or acoustic methods, however, do not work as well when the body is in motion, and thus require a patient or study subject to remain still.
The researchers overcame these challenges with the soft, skin-conforming electronic device that is applied directly onto the skin and uses thermal sensors to collect data on changes in temperature, including those caused by changes in blood flow. The device can also apply a small amount of heat in order to test a subject’s responses. In this mode, a miniature pad in the device generates a heat impulse, while 14 surrounding thermal sensors detect the resulting heat flux. The signal is sent to a computer that calculates the velocity of blood flow occurring within two millimeters of the skin surface.
In their study, the researchers placed the sensor on a study subject’s forearm, over a large, visible vein, and then applied pressure for 60 seconds at various positions near the vein. Each time, the device sensed corresponding reductions in blood flow. The researchers also used a thermal camera that measures infrared signals to confirm that the blood-flow sensor measurements were accurate, even when the subject moved around.
Next, they chose a placement on the forearm that was not near a large vein, so that the device would detect blood flow in micro-sized blood vessels within the underlying tissue. The researchers were able to detect changes in blood flow when the study subject took a deep breath. Members of the team at a collaborating institution performed a separate test that involved delivering a gentle slap to the skin near the electronic sensor, which caused a mild reddening reaction. The sensor registered the skin reaction as an increase of surface temperature, accompanied by a change in the direction of blood flow within two millimeters of the skin’s surface.
According to co-author Alexander Gorbach, Ph.D., head of NIBIB’s Infrared Imaging and Thermometry Unit, the tests performed with the thermal sensor helped to establish a number of guidelines for its use, such as optimal placement of the sensor, and how deeply under the skin’s surface the device can assess blood flow. At this stage, the device shows promise as a low-cost, readily-fabricated sensor for use in ambulatory or hospital-based settings. Because of the link between chronic hypertension and some types of vascular diseases, the new sensor may be a useful addition to studies of hypertension and its consequences.
The Latest on: Vascular disease monitoring
via Google News
The Latest on: Vascular disease monitoring
- Ambulatory Blood Pressure Monitoring Markets to 2024 with Analysis on Key Stakeholders - ResearchAndMarkets.com on February 19, 2019 at 7:27 am
The Global Ambulatory Blood Pressure Monitoring Market size is expected to reach $ ... Growing cases of hypertension, due to increasing prevalence of diabetes, obesity, and cardiovascular diseases has ... […]
- High-tech toilet seat monitors your heart as you sit on the can on February 19, 2019 at 6:00 am
If developing heart disease scares the poo out of you ... “The toilet seat–based cardiovascular monitoring system has the potential [to] fill a gap in patient monitoring by capturing trend ... […]
- Global Interventional Cardiology Market is Register CAGR 7.0% Growth during 2018-2023 on February 19, 2019 at 5:41 am
Interventional cardiology is the catheter-based treatment of cardiovascular diseases (CVDs). Certified cardiologists ... Interventional procedures in cardiology are carried out using cardiac monitorin... […]
- Monitoring Cardiotoxicity in Patients Receiving VEGF Inhibitors on February 18, 2019 at 8:45 am
Today we are discussing the detection and monitoring of cardiotoxicity that can arise in cancer patients receiving vascular endothelial growth factor ... and treats patients with cancer and heart dise... […]
- In Pediatric Heart Disease: Understanding Post-Fontan Risks, Improving Parental Bonding, and Video Telemedicine on February 18, 2019 at 8:00 am
Cardiology 2019, the 22nd Annual Update on Pediatric and Congenital Cardiovascular Disease, occurred Feb. 13 to Feb. 17 ... Children's Mercy Kansas City developed the Cardiac High Acuity Monitoring pr... […]
- T cell co-stimulation and co-inhibition in cardiovascular disease: a double-edged sword on February 15, 2019 at 9:16 am
T cell co-stimulation blockade is a promising therapeutic approach to prevent the progression of cardiovascular diseases. Intensive monitoring of patients treated with ICIs for cardiovascular toxicity ... […]
- Doctors Should Encourage Exercise in Patients With Diabetes, CV Disease on February 14, 2019 at 7:39 am
HealthDay News — Physicians need to take an active role in prescribing specific exercise training in patients with both type 2 diabetes mellitus and cardiovascular disease ... Remote guidance and moni... […]
- Continuous Cardiac Monitoring Devices Market Dynamics, Forecast, Analysis and Supply Demand 2017-2027 on February 13, 2019 at 7:59 pm
Majority of cardiovascular diseases could be managed by early detection of abnormalities in the functioning of heart. Continuous cardiac monitoring devices are used for observation of cardiac activity ... […]
- Multiparameter Patient Monitoring Market to Hit $11 Billion by 2025: Global Market Insights, Inc. on February 13, 2019 at 3:00 am
February 13, 2019 (Newswire.com) - China multiparameter patient monitoring market is estimated to grow at 4.8% from 2019 to 2025. According to the World Health Organization (WHO), over 230 million peo... […]
- Researchers present new findings on postpartum racial disparities and cardiovascular disease on February 12, 2019 at 7:48 am
Cardiovascular disease and hypertensive disorders are ... The first group received usual care for blood pressure monitoring (an in office visit 7—10 days postpartum). The second group was ... […]
via Bing News