Social and ethical issues arise beyond potential for preventing rare complex diseases
Sophisticated prenatal techniques, not yet in clinical practice, offer the potential to prevent a cruel multi-system genetic disease passing from mother to child long before birth.
But these emerging tools raise important questions: might there be unintended, even irreversible risks to the resulting child–or even that child’s future descendants? Are there potential risks to the mother’s health? What about other potential consequences if its use is broadened to include indications beyond strict disease prevention, such as adapting the tools into conception aids for older women?
The tools in question, mitochondrial replacement techniques (MRTs), aim to prevent mother-to-child transmission of mitochondrial DNA disease –a complex set of rare disorders caused by defective DNA within the mitochondria, the tiny energy-producing structures existing outside the nucleus of cells. Such disease may present at any age or level of severity, attacking a combination of organs and systems, often fatally. There are no current cures or approved therapies for any of these disorders, which clinicians manage by treating the diverse symptoms that may progressively affect each patient.
Earlier this month, an expert panel of national experts formed by the Institute of Medicine at the request of the U.S. Food and Drug Administration (FDA) recommended that research into MRTs should proceed under carefully proscribed guidelines.
Three members of that panel co-authored a Perspective article in today’s New England Journal of Medicine on MRT’s implications for clinicians. The article begins, “Mitochondrial DNA (mtDNA) disease may be the poster child for highly targeted, ‘personalized’ medicine.”
“Even though MRTs would not confer health benefits on patients who already have mitochondrial DNA diseases, many patients with a known risk for transmitting such a disease to their offspring are highly motivated to prevent that from occurring,” said Marni J. Falk, M.D., director of the Mitochondrial-Genetics Clinic at The Children’s Hospital of Philadelphia and first author of the article. “That motivation is clear when we counsel patients and families affected by mtDNA disease, and recent patient surveys have reinforced that preventing disease transmission is a prevailing concern in this population.”
Falk’s co-authors are Jeffrey Kahn, Ph.D., M.P.H., of the Johns Hopkins Berman Institute of Bioethics, and Alan Decherney, M.D., an obstetrician-gynecologist and reproductive endocrinologist at the National Institute of Child Health and Human Development.
Kahn chaired the Institute of Medicine expert panel.
Because the expert panel stated that the child’s safety was paramount, it recommended that MRTs should initially be studied only in male embryos, since males do not transmit mitochondrial DNA to their children. The panel further argued that the FDA should make clear policy and that professional societies should issue practice recommendations to limit future MRT usage to appropriate patients.
The authors repeat the panel’s stipulation that children conceived after MRT should be monitored long-term, “probably well into adulthood,” much longer than is done after in vitro fertilization with pre-implantation diagnosis for diseases based in nuclear DNA.
Finally, because MRTs require mixing mitochondrial DNA from a female donor with DNA from the nucleus of the mother and father, the authors note that researchers should investigate unanticipated health problems and possibly questions about identity, before regulatory approval or clinical use can occur for the techniques.
The Latest on: Mitochondrial DNA replacement
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The Latest on: Mitochondrial DNA replacement
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People have different nuclear genomes (genetic make-up) and different mitochondrial DNA sequences (mtDNA or ... When researchers have used mitochondrial replacement-type techniques to mix-and ...
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Since this would be a full replacement of this secondary ... along with a separate mitochondrial mother. As noted, replacing mitochondrial DNA will have a lesser impact than replacing ...
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1 Laboratory of Genetics, Genome Center of Wisconsin, Wisconsin Energy Institute, J. F. Crow Institute for the Study of Evolution, University of Wisconsin–Madison, Madison, WI, USA. 2 Microbiology ...
- The special considerations of gene therapy for mitochondrial diseaseson March 2, 2020 at 2:08 am
and may present significant challenges if not accounted for in the gene replacement strategy being employed. Fig. 1: Expression of a putative nuclear-encoded mitochondrial protein using a ...
- The Next Frontier of Mitochondrial Medical Applications (2020)on February 18, 2020 at 4:00 pm
mitochondrial replacement techniques (MRT) work to prevent transmitting mitochondrial DNA (mtDNA) diseases from mother to the next generation. Such diseases vary in presentation and severity. The goal ...
- Leigh Syndromeon February 14, 2020 at 9:07 am
Nearly 20% of these genes are located in mitochondrial DNA that is associated with energy production ... His mitochondrial disease was stabilized, and he underwent kidney replacement after extensive ...
- The American Canine Family Treeon October 15, 2018 at 3:21 pm
His team examined mitochondrial DNA in some 2,000 modern dogs, and while they found evidence for large-scale replacement of indigenous dogs, they also detected traces of ancient DNA in the modern ...
- Three-parent DNA baby treatments could now be legal in UK next springon November 30, 2016 at 9:41 am
The end result is the same - an embryo containing healthy mitochondria from the donor and nuclear DNA from the baby’s mother and father. In theory mitochondrial replacement can not only prevent ...
- Human embryo modifications must be halted, scientists urgeon March 26, 2015 at 11:00 am
More recently in the United Kingdom, there was a similar stop-and-reflect period on mitochondrial DNA replacement, the so-called three-parent baby technique. Advances in genome editing technologies ...
- UK Becomes First Country To Legalize Three-Parent IVFon February 25, 2015 at 7:11 am
The newly approved technique, which is called mitochondrial replacement therapy ... The result is a child whose DNA primarily comes from two parents, but 0.1% will come from a second woman.
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