Social and ethical issues arise beyond potential for preventing rare complex diseases
Sophisticated prenatal techniques, not yet in clinical practice, offer the potential to prevent a cruel multi-system genetic disease passing from mother to child long before birth.
But these emerging tools raise important questions: might there be unintended, even irreversible risks to the resulting child–or even that child’s future descendants? Are there potential risks to the mother’s health? What about other potential consequences if its use is broadened to include indications beyond strict disease prevention, such as adapting the tools into conception aids for older women?
The tools in question, mitochondrial replacement techniques (MRTs), aim to prevent mother-to-child transmission of mitochondrial DNA disease –a complex set of rare disorders caused by defective DNA within the mitochondria, the tiny energy-producing structures existing outside the nucleus of cells. Such disease may present at any age or level of severity, attacking a combination of organs and systems, often fatally. There are no current cures or approved therapies for any of these disorders, which clinicians manage by treating the diverse symptoms that may progressively affect each patient.
Earlier this month, an expert panel of national experts formed by the Institute of Medicine at the request of the U.S. Food and Drug Administration (FDA) recommended that research into MRTs should proceed under carefully proscribed guidelines.
Three members of that panel co-authored a Perspective article in today’s New England Journal of Medicine on MRT’s implications for clinicians. The article begins, “Mitochondrial DNA (mtDNA) disease may be the poster child for highly targeted, ‘personalized’ medicine.”
“Even though MRTs would not confer health benefits on patients who already have mitochondrial DNA diseases, many patients with a known risk for transmitting such a disease to their offspring are highly motivated to prevent that from occurring,” said Marni J. Falk, M.D., director of the Mitochondrial-Genetics Clinic at The Children’s Hospital of Philadelphia and first author of the article. “That motivation is clear when we counsel patients and families affected by mtDNA disease, and recent patient surveys have reinforced that preventing disease transmission is a prevailing concern in this population.”
Falk’s co-authors are Jeffrey Kahn, Ph.D., M.P.H., of the Johns Hopkins Berman Institute of Bioethics, and Alan Decherney, M.D., an obstetrician-gynecologist and reproductive endocrinologist at the National Institute of Child Health and Human Development.
Kahn chaired the Institute of Medicine expert panel.
Because the expert panel stated that the child’s safety was paramount, it recommended that MRTs should initially be studied only in male embryos, since males do not transmit mitochondrial DNA to their children. The panel further argued that the FDA should make clear policy and that professional societies should issue practice recommendations to limit future MRT usage to appropriate patients.
The authors repeat the panel’s stipulation that children conceived after MRT should be monitored long-term, “probably well into adulthood,” much longer than is done after in vitro fertilization with pre-implantation diagnosis for diseases based in nuclear DNA.
Finally, because MRTs require mixing mitochondrial DNA from a female donor with DNA from the nucleus of the mother and father, the authors note that researchers should investigate unanticipated health problems and possibly questions about identity, before regulatory approval or clinical use can occur for the techniques.
The Latest on: Mitochondrial DNA replacement
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The Latest on: Mitochondrial DNA replacement
- Disease-causing mutations in subunits of OXPHOS complex I affect certain physical interactionson July 10, 2019 at 2:17 am
Here, we created such a platform by cloning all 37 nuclear DNA (nDNA) and 7 mitochondrial DNA (mtDNA)-encoded human ... pathological frame-shift mutation in the MT-ND2 gene, causing the replacement of ... […]
- Mitochondrial Akt Signaling Modulated Reprogramming of Somatic Cellson July 9, 2019 at 2:27 am
In our DNA microarray analysis, the top ranking genes positively modulated by activation of mitochondrial Akt1 in hESCs were ... the cell fate specification process. Knockout serum replacement (KOSR), ... […]
- DNA discovery could have implications for mitochondrial donation treatmenton May 23, 2019 at 5:00 pm
It involves substituting a mother’s nuclear DNA into a donor egg while retaining the donor’s mitochondria. “Mitochondrial replacement therapy is an important new treatment to enable mothers to have ... […]
- Interplay between mitochondria and nucleus may have implications for new treatmenton May 23, 2019 at 11:23 am
It involves substituting a mother's nuclear DNA into a donor egg while retaining the donor's mitochondria. "Mitochondrial replacement therapy is an important new treatment to enable mothers to have ... […]
- Three-parent DNA baby treatments could now be legal in UK next springon May 22, 2019 at 2:14 pm
... when mitochondrial DNA (mtDNA) goes wrong the results can be catastrophic, leading to a wide range of potentially fatal conditions affecting vital organs, muscles, vision, growth and mental ... […]
- Mitochondrial Donation — Which Women Could Benefit?on May 16, 2019 at 1:23 am
Mitochondrial donation allows the replacement of mutated mitochondrial DNA (mtDNA) in human oocytes or zygotes, offering at-risk couples the chance of having their own healthy child. HFEA licensing ... […]
- U.S. researcher says he’s ready to start pregnancies with ‘three-parent’ embryoson April 19, 2019 at 7:22 am
Mutations in mitochondrial DNA can cause serious genetic diseases ... There, he transferred an embryo created with mitochondrial replacement therapy into a woman who’s a carrier of Leigh syndrome. She ... […]
- Patient advocates and scientists launch push to lift ban on ‘three-parent IVF’on April 16, 2019 at 1:39 am
These diseases are inherited from the mother’s DNA, so mitochondrial replacement therapy involves taking the nucleus of the mother’s egg and swapping it into a donor egg that has had its nucleus ... […]
- 3 biological parents, 1 child, and an international controversyon July 24, 2018 at 5:42 am
This mitochondrial replacement therapy, or MRT, has made headlines for producing “three-parent babies” because it involves replacing the mitochondrial DNA of an embryo that has a risk of mitochondrial ... […]
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