This is a coronary artery structure being 3-D bioprinted.
CREDIT
Carnegie Mellon University College of Engineering
Models of hearts, arteries, bones and brains are 3-D printed out of biological materials
As of this month, over 4,000 Americans are on the waiting list to receive a heart transplant. With failing hearts, these patients have no other options; heart tissue, unlike other parts of the body, is unable to heal itself once it is damaged. Fortunately, recent work by a group at Carnegie Mellon could one day lead to a world in which transplants are no longer necessary to repair damaged organs.
“We’ve been able to take MRI images of coronary arteries and 3-D images of embryonic hearts and 3-D bioprint them with unprecedented resolution and quality out of very soft materials like collagens, alginates and fibrins,” said Adam Feinberg, an associate professor of Materials Science and Engineering and Biomedical Engineering at Carnegie Mellon University. Feinberg leads the Regenerative Biomaterials and Therapeutics Group, and the group’s study was published in the October 23 issue of the journal Science Advances. A demonstration of the technology can be viewed online.
“As excellently demonstrated by Professor Feinberg’s work in bioprinting, our CMU researchers continue to develop novel solutions like this for problems that can have a transformational effect on society,” said Jim Garrett, Dean of Carnegie Mellon’s College of Engineering. “We should expect to see 3-D bioprinting continue to grow as an important tool for a large number of medical applications.”
Traditional 3-D printers build hard objects typically made of plastic or metal, and they work by depositing material onto a surface layer-by-layer to create the 3-D object. Printing each layer requires sturdy support from the layers below, so printing with soft materials like gels has been limited.
“3-D printing of various materials has been a common trend in tissue engineering in the last decade, but until now, no one had developed a method for assembling common tissue engineering gels like collagen or fibrin,” said TJ Hinton, a graduate student in biomedical engineering at Carnegie Mellon and lead author of the study.
“The challenge with soft materials — think about something like Jello that we eat — is that they collapse under their own weight when 3-D printed in air,” explained Feinberg. “So we developed a method of printing these soft materials inside a support bath material. Essentially, we print one gel inside of another gel, which allows us to accurately position the soft material as it’s being printed, layer-by-layer.”
One of the major advances of this technique, termed FRESH, or “Freeform Reversible Embedding of Suspended Hydrogels,” is that the support gel can be easily melted away and removed by heating to body temperature, which does not damage the delicate biological molecules or living cells that were bioprinted. As a next step, the group is working towards incorporating real heart cells into these 3-D printed tissue structures, providing a scaffold to help form contractile muscle.
Bioprinting is a growing field, but to date, most 3-D bioprinters have cost over $100,000 and/or require specialized expertise to operate, limiting wider-spread adoption. Feinberg’s group, however, has been able to implement their technique on a range of consumer-level 3-D printers, which cost less than $1,000 by utilizing open-source hardware and software.
Read more: Carnegie Mellon researchers hack off-the-shelf 3-D printer towards rebuilding the heart
The Latest on: 3-D bioprinting
via Google News
The Latest on: 3-D bioprinting
- Allevi and Lonza: A New Partnership Combines Bioprinting Technology with Cell Cultureon December 9, 2019 at 10:07 pm
and patterning cells in physiological relevant patterns is the key-value 3D bioprinting provides. So it makes total sense to start bundling cells with biomaterials to users who want to continue to ...
- GE enters 3D bioprinting partnership with ASLSon December 9, 2019 at 5:48 pm
LONDON – GE Healthcare Life Sciences is bringing its heft to 3D bioprinting in an agreement with Advanced Solutions Life Science Inc. (ASLS), in which the partners aim to automate the production of ...
- Graftless Bone Transplants Soon to Be Reality: ADAM Takes 3D Bones to Clinical Trialson December 3, 2019 at 5:00 am
3D printing has been discussed as something of a magic bullet of organ and bone transplants for some time — and that's just the problem. It has been nearly two decades since the first bioprinting ...
- 3D Bioprinting Market Is Expected to Reach USD 4,306.6 Million by 2025, at a CAGR of 21.40% Between 2019 and 2025on November 27, 2019 at 9:31 am
Lucrative Growth of 3D Bioprinting Industry Owing to Rising Healthcare Initiatives The increase in the geriatric population and the rise in the prevalence of chronic diseases are the major factors ...
- 3D BIOPRINTING EQUIPMENT MARKETon November 25, 2019 at 5:01 am
The "3D Bioprinting Equipment market report 2019" is to introduce, segment, project a market size, and to describe the content regarding the factors shaping the overall industry. The report also ...
- 3D Bioprinting Market : Highly adopting technology in Healthcare Industryon November 20, 2019 at 1:26 am
3D Bioprinting Market Outlook 2019-2026: Global 3D Bioprinting Market Major players added are Cyfuse Biomedical K.K., BioBots, Organovo Holdings Inc., EnvisionTEC ...
- Bioprinting: An Analysis of the New Age of 3D-Printing and Its Engineeringon November 18, 2019 at 7:36 pm
One note before I begin: if you would like a more general analysis of bioprinting and of its future, I recommend reading my past article linked here. But if you’d like a more technical narrative of ...
- Top Companies in 3D Bioprinting Market | Size and Share Analysis, Future Technology, Application and Global 3d Organ Printing Industry Trends By 2023on November 18, 2019 at 3:46 am
The global 3D Bioprinting Market size and share is projected to reach USD 1,923.02 million at a 24.59% CAGR by 2023, reveals the latest Market Research Future (MRFR) report. 3D bioprinting is a branch ...
- 3D Bioprinting Market Global Industry Outlook, Opportunity Analysis and Forecast 2019-2024on November 16, 2019 at 9:50 am
A latest published report on “3D Bioprinting Market” delivering key insights and providing a competitive advantage to clients through a detailed report. The report also details the information about ...
- The 3D bioprinting market is projected to reach USD 1,647 million by 2024 from USD 651 million in 2019, at a CAGR of 20.4% from 2019 to 2024on October 7, 2019 at 5:00 pm
New York, Oct. 08, 2019 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "3D Bioprinting Market by Component, Material, Application, End user ...
via Bing News