Infectious diseases such as hepatitis C and some of the world’s deadliest superbugs–C. difficile and MRSA among them–could soon be detected much earlier by a unique diagnostic test, designed to easily and quickly identify dangerous pathogens.
Researchers at McMaster University have developed a new way to detect the smallest traces of metabolites, proteins or fragments of DNA. In essence, the new method can pick up any compound that might signal the presence of infectious disease, be it respiratory or gastrointestinal.
“The method we have developed allows us to detect targets at levels that are unprecedented,” says John Brennan, director of McMaster’s Biointerfaces Institute, where the work was done. This new method is described online in the journal Angewandte Chemie International Edition.
“The test has the best sensitivity ever reported for a detection system of this kind – it is as much as 10,000 times more sensitive than other detection systems,” he says.
Using sophisticated techniques, researchers developed a molecular device made of DNA that can be switched ‘on’ by a specific molecule of their choice–such as a certain type of disease indicator or DNA molecule representing a genome of a virus–an action that leads to a massive, amplified signal which can be easily spotted.
Another important advantage of the new test, say researchers, is that the method does not require complicated equipment so tests can be run at room temperature under ordinary conditions.
“This will be the foundation for us to create future diagnostic tests”, explains Yingfu Li, a professor in the Departments of Biochemistry and Biomedical Sciences, Chemistry and Chemical Biology.
“This invention will allow us to detect anything we might be interested in, bacterial contamination or perhaps a protein molecule that is a cancer marker. Our method can sensitively detect all of them, and it can do so in a relatively short period of time.”
Researchers are currently working to move the test onto a paper surface to create a portable point-of-care test, which would completely eliminate the need for lab instruments, allowing users–family physicians, for example–to run the test.
The Latest on: Infectious disease test
via Google News
The Latest on: Infectious disease test
- Self-testing for HIV & barriers to reducing concussionson November 19, 2019 at 7:57 pm
First CRISPR treatment for blood diseases shows early benefits in two patients Why fentanyl is deadlier than heroin, in a single… Why fentanyl is deadlier than heroin, in a single photo HHS proposed ...
- NIH Awards Grant to Enable Biosciences to Develop Lab Methods for At-Home Testing for Type 1 Diabetes Riskon November 19, 2019 at 5:13 pm
Nov. 19, 2019 /PRNewswire/ -- The National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) division of the National Institutes of Health (NIH) has awarded a Phase II Small Business ...
- Chinese Parents Test DNA to Check If Kids Will Become Prodigieson November 19, 2019 at 1:00 pm
The center focuses on analyzing genetic and biological data to prevent and treat diseases. “DNA tests can be one of the drivers and the motivator, so parents can provide more focused resources to ...
- Cardiac POC Testing Devices and Kits Market 2019 Global Leading Companies Analysis, Revenue, Trends and Forecasts 2025on November 19, 2019 at 6:12 am
As per the latest report, the global cardiac POC testing devices and kits market is expected to see rapid growth in the coming years. Surge in coronary artery diseases and ischemic heart diseases due ...
- Launch of Index At-Home Biological Age Test: Interview with Dr. Morgan Levine, Yale School of Medicine and Head of Bioinformatics at Elysium Healthon November 18, 2019 at 12:48 pm
The company claims that the test allows users to determine their biological age at home, and provides science-backed healthy living recommendations that may be able to impact overall health. Aging is ...
- The U.S. needs extra action to eliminate viral hepatitis, the nation’s deadliest infectious diseaseon November 15, 2019 at 1:59 am
For a while the complications were minimal, but by the early 2000s my tests began to show signs of liver disease. By 2008, I had signs of cirrhosis, which is scarring of the liver, a sign of ...
- U.N. to test impact of mosquito 'birth control' on disease spreadon November 14, 2019 at 12:19 pm
The U.N. said Thursday it was preparing to test a sterilization technique targeting mosquitoes that could help rein in the spread of a range of devastating diseases such as dengue and Zika.
- Rapid triage test distinguishes between active TB and TB-like diseases in adultson November 14, 2019 at 11:07 am
They validated the model in a cohort of 317 subjects from Peru, South Africa and Vietnam, which showed that the test distinguished active TB from other TB-like diseases with a sensitivity of 80% ...
- UN to test impact of mosquito sterilisation on disease spreadon November 14, 2019 at 8:27 am
Geneva (AFP) - The UN said Thursday it was preparing to test a sterilisation technique targeting mosquitoes that could help rein in the spread of a range of devastating diseases such as dengue and ...
- DNA Test At Birth Can Save Thousands Of Babies From Inherited Diseaseson November 9, 2019 at 2:00 am
A new scheme will be launched next year to save the lives of thousands of babies who are at increased risk of several genetic diseases, including cystic fibrosis and Huntington’s. The new scheme will ...
via Bing News