Multi-Functional Printable Silk Inks Tap Common Print Technology to Address Therapeutics, Regenerative Medicine, Bio-Sensing Needs
Silk inks containing enzymes, antibiotics, antibodies, nanoparticles and growth factors could turn inkjet printing into a new, more effective tool for therapeutics, regenerative medicine and biosensing, according to new research led by Tufts University biomedical engineers and published June 16 in the journal Advanced Materials online in advance of print.
Inkjet printing is one of the most immediate and accessible forms of printing technology currently available, according to the researchers, and ink-jet printing of biomolecules has been previously proposed by scientists. However, the heat-sensitive nature of these unstable compounds means printed materials rapidly lose functionality, limiting their use.
Enter purified silk protein, or fibroin, which offers intrinsic strength and protective properties that make it well-suited for a range of biomedical and optoelectronic applications. This natural polymer is an ideal “cocoon” that can stabilize compounds such as enzymes, antibodies and growth factors while lending itself to many different mechanically robust formats, said Fiorenzo Omenetto, Ph.D., senior author on the paper and associate dean for research and Frank C. Doble Professor of Engineering at Tufts School of Engineering.
“We thought that if we were able to develop an inkjet-printable silk solution, we would have a universal building block to generate multiple functional printed formats that could lead to a wide variety of applications in which inks remain active over time,” he said.
By using this simple approach and starting with the same base material, the research team created and tested a “custom library” of inkjet-printable, functional silk inks doped with a variety of components:
Bacterial-sensing polydiacetylenes (PDAs) printed on surgical gloves; the word “contaminated” printed on the glove changed from blue to red after exposure to E. coli
Proteins that stimulate bone growth (BMP-2) printed on a plastic dish to test topographical control of directed tissue growth
Sodium ampicillin printed on a bacterial culture to test the effectiveness of a topographical distribution of the antibiotic
Gold nanoparticles printed on paper, for possible application in photonics and biology (e.g., color engineering, surface plasmon resonance based sensing and bio-imaging)
Enzymes printed on paper to test the ability of the ink to entrain small functional biomolecules
The researchers, who included collaborators from the University of Illinois at Urbana-Champaign, foresee wide potential for future investigation and application of this technology.
For example, Omenetto envisions more work on the bio-sensing gloves, which he says could selectively react to different pathological agents. The ability to print antibiotics in topographical patterns could address the need for “smart” bandages, where therapeutics are incorporated and delivered to match a complex injury.
The Latest on: Bioactive silk
via Google News
The Latest on: Bioactive silk
- Smart Fabrics Monitor Vital Signs Using Bioactive Inkon November 23, 2020 at 4:00 pm
The active ingredients in the new solution are silk-based inks that are biologically activated, researchers said. They created the inks by embedding what is called “reporter” molecules—such as ...
- Smart Bio Awards recognises innovators making an impact in Biotechnologyon November 21, 2020 at 9:42 pm
They contain bio-active silk protein in the form of fibroin and asiaticoside, which heals wound faster and with reduced scar formation. It is suitable to treat all types of wounds. A multi ...
- Five Smart Bio Awards announcedon November 21, 2020 at 3:38 pm
The products, containing bio-active silk protein, heal wound faster and with reduced scar formation. Nibedit Dey, founder and CEO of Ibrum Technologies, a multidisciplinary engineer and creative ...
- Acta biomaterialiaon November 17, 2020 at 4:00 pm
Thermally triggered injectable chitosan/silk fibroin/bioactive glass nanoparticle hydrogels for in-situ bone formation in rat calvarial bone defects. Construction of vascularized tissue-engineered ...
- Biotechnology journalon November 8, 2020 at 4:00 pm
Phosphorylation of silk fibroins improves the cytocompatibility of silk fibroin derived materials: a platform for the production of tuneable material. A functional high-content miRNA screen ...
- Next-gen skincare, silk without spiders and pollution for lunch: Meet the biotech startups pitching at IndieBio’s Demo Dayon October 27, 2020 at 9:59 am
Spintex: CEO Alex Greenhalgh is creating a new, scalable way of making silk. The company mimics spider spinning ... Brightcure: Chiara Heide, CEO of Brightcure, has created a bioactive cream that uses ...
- Biomaterials Market Size is Projected to Reach USD 215,920.01 Million by 2025 - Valuates Reportson October 21, 2020 at 7:34 am
The Natural Biomaterials further studied across Alginates, Cellulose, Chitin, Collagen, Fibrin, Gelatin, Hyaluronic Acid, and Silk ... Market studied across Bioactive Biomaterials, Bioinert ...
- The Best Mineral Sunscreens for Your Face (and We Tested Them All)on September 18, 2020 at 9:26 am
The formula is thin and feels like silk on your skin, leaving a matte (but not too matte) finish on your face. The zinc is coupled with vitamins C and E for extra protection against those evil free ...
- IIT Guwahati Scientists Develop Silk Mats That Could Treat Arthritison August 6, 2017 at 3:42 am
"We used silk, a natural protein to fabricate electrospun mats to mimic the cartilage portion and bioactive glass to develop a composite material, similar to the natural tissue," said Mr Mandal.
- Great gifts for the jet setting momon May 1, 2012 at 6:45 am
ve=1&tl=1 Branche Silk Charmeuse Pillow Case $84.00 ... Dream Serum +100 Concentrate is packed with 109 antioxidant-rich bioactive botanicals," said Nancy Trent founder and president of ...
via Bing News