- A DNA vaccine helped lower blood pressure for up to six months, reduced tissue damage to the heart and blood vessels associated with hypertension in rats.
- If future research shows the vaccine is a viable treatment option in humans, it could improve high blood pressure levels.
A vaccine may one day help lower blood pressure for up to six months, according to new research in the American Heart Association’s journal Hypertension.
The study in rats may eventually provide a novel alternative to treat high blood pressure in people, who would not need to take a pill everyday.
“The potential of a vaccine for hypertension offers an innovative treatment that could be very effective for the control of non-compliance which is one of the major problems in the management of hypertensive patients,” said Hironori Nakagami M.D., Ph.D., study co-author and professor at Osaka University in Japan.
Researchers have designed a DNA vaccine that targets angiotensin II ? a hormone that raises blood pressure by causing blood vessels to constrict. This narrowing can increase your blood pressure and force your heart to work harder.
In the study, researchers immunized hypertensive rats three times at two-week intervals with needleless injections. The vaccine not only lowered blood pressure for up to six months, but also reduced tissue damage to the heart and blood vessels associated with hypertension. There were no signs of damage to other organs such as the kidney or liver.
The DNA vaccine works similar to common ACE inhibitor blood pressure medications which help blood vessels relax and open up, which, in turn, lowers blood pressure. Other types of vaccines have been tested for hypertension (e.g. a peptide vaccine), but didn’t have lasting effects and some had undesirable side effects.
The ultimate goal of an anti-hypertensive vaccine is to achieve perfect blood pressure control by improving drug compliance through the vaccine. In addition, in the developing countries like Africa and south Asia, anti-hypertensive drugs such as ARB (angiotensin receptor blockade) are expensive. A DNA vaccine may provide cheaper and effective anti-hypertensive treatments in such countries, researchers said.
The Latest on: DNA vaccine
via Google News
The Latest on: DNA vaccine
- Record Growth in Global Tourism Escalates Travel Vaccine Market over the Forecast Period (2019-2025)on November 27, 2019 at 9:19 am
Conjugate Vaccines, DNA Vaccines, and Recombinant Vector Vaccines): Global Industry Analysis, Trends, Size, Share and Forecasts to 2025". Travel vaccines, also called travel immunizations shots ...
- Building a better malaria vaccineon November 27, 2019 at 6:11 am
Kappe is also working on a live attenuated malaria vaccine. Instead of hobbling the parasite with radiation, Kappe uses gene editing. A crucial DNA-packaging protein is sabotaged using the ...
- Worldwide Markets for Viral Vectors, Non-Viral...on November 27, 2019 at 2:44 am
The chapter provides details on the year of establishment, scale of production, location of manufacturing facilities, type of vectors manufactured (AAV, adenoviral, lentiviral, retroviral, plasmid DNA ...
- Research could help design better flu vaccineson November 26, 2019 at 5:12 pm
But, at best, the vaccine is only effective 40% to 60% of the time ... When a gene is expressed in a cell it means the DNA has been used to produce RNA for this gene. The gene expression in cells can ...
- Help Me, Heidi! Are the Flu and TDap Vaccines Really Safe During Pregnancy?on November 26, 2019 at 12:30 pm
That’s in our mom — and dad — DNA. And that’s what programs us to worry a lot during pregnancy — about ... Not only is your OB wise to recommend both a seasonal flu shot and a well-timed Tdap vaccine ...
- How the flu shot affects your genes could make it betteron November 26, 2019 at 11:59 am
Mias and his coauthors reanalyzed data from 18 previously published studies where scientists had taken blood samples from flu patients and vaccine recipients and studied those samples for gene ...
- Applied DNA Sciences Reports 14 Development Customers for its Linear DNA Manufacturing Platformon November 25, 2019 at 4:07 pm
DNA vaccines against infectious agents and cancer, and CAR T therapies with a variety of transfection and transduction technologies, as well as several others using our platform as a template for RNA ...
- Brucella Abortus Vaccine Market: Huge Growth Opportunities and Challenges to Watch in 2019on November 25, 2019 at 10:16 am
The report on Brucella Abortus Vaccine mentions key developments and activities executed by leading service ... Hester Biosciences Qilu Animal Health Segment by Regions North America Europe China ...
- Longer-term data fail to clear concern over Takeda's dengue vaccineon November 23, 2019 at 8:07 am
Takeda's vaccine is based on a dengue 2 virus, with DNA from the other three added in. In the study, the vaccine performed best against dengue 2, proving 95.1 per cent effective. That helped drive the ...
- Irradiated Animal Vaccines Keep Ethiopia's Animals Healthy, Helping Exports and Food Securityon November 20, 2019 at 7:29 am
The IAEA played a pivotal role in the establishment of the Institute’s molecular laboratory, where new strains of viruses are characterized, so that vaccines can be adjusted to provide protection ...
via Bing News