An interdisciplinary team from The University of Texas Medical Branch at Galveston and Profectus BioSciences, Inc. has developed a quick-acting vaccine that is both safe and effective with a single dose against the Ebola strain that killed thousands of people in West Africa last year.
These findings are detailed in the new edition of Nature.
During 2014, the outbreak of the West African Makona strain of Ebola Zaire virus killed nearly 10,000 and caused worldwide concern. With increasing population growth in West Africa, the frequency of contact between humans and natural Ebola virus hosts such as bats will likely rise, potentially leading to more catastrophic outbreaks.
Many vaccine approaches have shown promise in being able to protect nonhuman primates against Ebola Zaire. In response to the Ebola Zaire outbreak, several of these vaccines have been fast tracked for human use.
One of those vaccines, developed by UTMB and Profectus, has been undergoing testing in the Galveston National Laboratory, the only fully operational Biosafety Level 4 laboratory on an academic campus in the U.S.
“These findings may pave the way for the identification and manufacture of safer, single dose, high efficiency vaccines to combat current and future Ebola outbreaks,” said Thomas Geisbert, UTMB professor of microbiology and immunology. “We are excited at the possibility of helping develop a way to stop this deadly disease. We have a lot of more work to accomplish but it’s important to note that this is a big step.”
The research team developed a vaccine effective against Ebola Zaire with a single dose in a nonhuman primate model. This new vaccine employs a virus not harmful to humans called vesicular stomatitis virus that had a part of the Ebola virus inserted into it. This “Trojan horse” vaccine safely triggered an immune response against Ebola Zaire.
To address any possible safety concerns associated with this vaccine, the team developed two next generation candidate vaccines that contain further weakened forms of the vaccine. Both of these vaccines produced an approximately ten-fold lower level of virus in the blood compared to the first generation vaccine.
“It was not known whether any of these vaccines could provide protection against the new outbreak West African Makona strain of Ebola Zaire currently circulating in Guinea,” said John Eldridge, Chief Scientific Officer-Vaccines at Profectus Biosciences, Inc. “Our findings show that our candidate vaccines provided complete, single dose protection from a lethal amount of the Makona strain of Ebola virus.”
The Latest on: Ebola
via Google News
The Latest on: Ebola
- Here are some key people who made an Ebola vaccine happenon January 9, 2020 at 5:14 pm
Many people contributed to the development of Merck’s Ebola vaccine, the first licensed one for the disease based on data showing it works in humans. From the earliest work to turn a livestock virus ...
- What Will It Take To Finally End Congo's Ebola Outbreak In 2020?on January 9, 2020 at 4:14 am
Last fall, Félix Tshisekedi, the president of Democratic Republic of Congo, made a triumphant prediction: Before 2019 was over, the Ebola outbreak that had ravaged his country for over a year would ...
- The complex logistics of Ebola responseon January 9, 2020 at 1:53 am
How do you deliver nearly three tons of supplies every day to halt Ebola in the Democratic Republic of the Congo’s (DRC) conflict-affected north-eastern region? For the World Health Organization (WHO) ...
- Democratic Republic of Congo: Ebola Virus Disease - External Situation Report 74on January 7, 2020 at 11:27 am
Since the last Situation Report 73 issued on 24 December 2019, 28 new confirmed Ebola virus disease (EVD) cases were reported from five health zones in two affected provinces in the Democratic ...
- Pharmalittle: The inside story of an Ebola vaccine; fewer adults received opioid prescriptionson January 7, 2020 at 6:33 am
Hello, everyone, and how are you today? We are doing just fine, thank you, as we ease back into a new year. The short person has returned to the local schoolhouse and the official mascot has resumed ...
- Weekend Update: The Girl You Wish You Hadn't... on the Ebola Viruson January 6, 2020 at 1:31 pm
- Ministry of Health Lauds Partners for Support during Ebola Preparedness Response in Ugandaon January 6, 2020 at 12:30 am
Kampala 6 January 2020: - The Minister of Health, Dr Jane Ruth Aceng lauded partnership and coordination as the key drivers for the Ebola Virus Disease (EVD) preparedness response in Uganda. This was ...
- An Ebola patient treated in the U.S. chose to remain anonymous. Now he's telling his story.on January 4, 2020 at 7:30 am
Years of disabling PTSD followed Preston Gorman's unlikely survival after he contracted the fearsome disease in Sierra Leone.
- Pig Ebola Might Make Tyson’s Stock Price Go Hog-Wildon January 3, 2020 at 8:12 am
African swine fever virus or ASFV is a viral hemorrhagic fever, which originates in populations of warthogs and other wild pigs in Africa. With symptoms similar to the dreaded Ebola virus, ASFV ...
- Congo Ebola crisis: To fight disease, an anthropologist heals distruston January 3, 2020 at 7:44 am
Congo’s Ebola outbreak is not just a health crisis. It’s also a social crisis – and it’s this anthropologist’s job to heal it.
via Bing News