UNSW biomedical engineer Melissa Knothe Tate is using previously top-secret semiconductor technology to zoom through organs of the human body, down to the level of a single cell.
A world-first UNSW collaboration that uses previously top-secret technology to zoom through the human body down to the level of a single cell could be a game-changer for medicine, an international research conference in the United States has been told.
The imaging technology, developed by high-tech German optical and industrial measurement manufacturer Zeiss, was originally developed to scan silicon wafers for defects.
UNSW Professor Melissa Knothe Tate, the Paul Trainor Chair of Biomedical Engineering, is leading the project, which is using semiconductor technology to explore osteoporosis and osteoarthritis.
Using Google algorithms, Professor Knothe Tate – an engineer and expert in cell biology and regenerative medicine – is able to zoom in and out from the scale of the whole joint down to the cellular level “just as you would with Google Maps”, reducing to “a matter of weeks analyses that once took 25 years to complete”.
Her team is also using cutting-edge microtome and MRI technology to examine how movement and weight bearing affects the movement of molecules within joints, exploring the relationship between blood, bone, lymphatics and muscle.
“For the first time we have the ability to go from the whole body down to how the cells are getting their nutrition and how this is all connected,” said Professor Knothe Tate. “This could open the door to as yet unknown new therapies and preventions.”
Professor Knothe Tate is the first to use the system in humans. She has forged a pioneering partnership with the US-based Cleveland Clinic, Brown and Stanford Universities, as well as Zeiss and Google to help crunch terabytes of data gathered from human hip studies.
Similar research is underway at Harvard University and Heidelberg in Germany to map neural pathways and connections in the brains of mice.
Professor Knothe Tate presented several papers on her research into the human hip and osteoarthritis at the peer-reviewed Orthopedic Research Society meeting in Las Vegas.
Numerous studies have explored molecular transport within specific tissues but there has been little research on exchange between different kinds of tissue such as cartilage and bone.
Professor Knothe Tate has already demonstrated a link between molecular transport through blood, muscle and bone, and disease status in osteoarthritic guinea pigs.
Like humans, guinea pigs develop osteoarthritis as they age. The condition is increasingly believed to be the result of a breakdown in cellular communication.
Understanding the molecular signaling and traffic between tissues could unlock a range of treatments, including physical therapies and preventative exercise routines, Professor Knothe Tate said.
Critical to this work has been the development of microscopy that allows seamless imaging of organs and tissues across length scales – centimetres at the whole-joint level down to nanometer-sized molecules – as well as the capacity to sift and analyse huge sets of data.
Professor Knothe Tate likened using the Zeiss technology in the hipbone to Google Maps’ ability to zoom down from an Earth View to Street View.
The Latest on: Biomedical engineering
via Google News
The Latest on: Biomedical engineering
- Sophisticated chip mimics the effects of osteoarthritis to develop effective drugson August 25, 2019 at 11:27 am
The study was published in Nature Biomedical Engineering. Not only did it produce the revolutionary chip but, while the tiny device was undergoing experimentation, the study also demonstrated that the ...
- Furce, Ronald Edwardon August 24, 2019 at 9:00 pm
He married Sybil Furce on October 15, 1971, in Stamford, Conn. He moved to the Shenandoah Valley in 1980, where he worked as a biomedical engineer for Shenandoah Shared Hospital Services for more than ...
- Engineering collagen-binding serum albumin (CBD-SA) as a drug conjugate carrier for cancer therapyon August 23, 2019 at 6:32 am
Medical researchers often use serum albumin (SA) as a drug carrier to deliver cytotoxic agents to tumors during biomedical drug ... Pritzker School of Molecular Engineering in the University ...
- Director/Tenure-Track Professor, School of Biomedical Scienceson August 22, 2019 at 8:31 pm
The University of Hong Kong 's highest priorities are to create opportunities for the very best academic talents to excel and to advance human knowledge to the benefit of society. We serve the needs ...
- US tariffs on monkeys could drive America’s biomedical research laboratories abroadon August 21, 2019 at 10:38 pm
Bailey, executive director of the National Association for Biomedical Research, a trade group. That would harm American interests in “extensive and wide-ranging” ways, he said. “The increased tariffs ...
- U of T researchers to harness quantum properties of light for biomedical imaging, security and moreon August 20, 2019 at 1:32 pm
Researchers at the University of Toronto’s Faculty of Applied Science & Engineering are designing portable ... But the technology could also enable advances in other fields, such as the biomedical ...
- World Chitosan Market Analysis 2019-2025: Focus on Water Treatment, Pharmaceutical & Biomedical, Cosmetics, Food & Beverages, and Other Applicationson August 20, 2019 at 4:35 am
Dublin, Aug. 20, 2019 (GLOBE NEWSWIRE) -- The "Chitosan Market Size, Share & Trends Analysis Report By Application (Pharmaceutical & Biomedical ... increasing R&D for product application in tissue ...
- GV creates new biomedical & cybernetic engineering degreeson August 19, 2019 at 9:38 pm
Grand Valley State University works hard to be an adaptive and advancing school, often creating new degrees to satisfy a changing job market and economy. As both of these things change, GVSU has ...
- 3D Printing Therapeutic Proteins With A New Bioink By Texas A&M Engineering Teamon August 16, 2019 at 1:21 am
TAMU researchers led by Akhilesh Gaharwar, an assistant professor in the Department of Biomedical Engineering, came up with an innovative way to design biologically active inks that control and ...
- Biomedical Refrigerators and Freezers Market Analysis Highlighting Opportunities and Development Status During 2017-2022on August 15, 2019 at 4:49 am
Rockville, MD -- (SBWIRE) -- 08/15/2019 -- In order to dissert the market scenario prevailing across the biomedical refrigerators and freezers market sector, Fact.MR has evenly presented a ...
via Bing News